SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ucn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 8 CYH A  47
ASP A  49
HIS A 103
CYH A 106
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
 0.18A 1ekjA-3ucnA:
21.8
1ekjB-3ucnA:
21.4		 1ekjA-3ucnA:
28.69
1ekjB-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 8 CYH A  47
ASP A  49
HIS A 103
CYH A 106
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
 1.01A 1ekjA-3ucnA:
21.8
1ekjB-3ucnA:
21.4		 1ekjA-3ucnA:
28.69
1ekjB-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		6 / 8 CYH A  47
ASP A  49
VAL A  71
HIS A 103
CYH A 106
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
 0.33A 1ekjA-3ucnA:
21.8
1ekjB-3ucnA:
21.4		 1ekjA-3ucnA:
28.69
1ekjB-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		4 / 6 CYH A  47
ASP A  49
VAL A  71
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
AZI  A 229 (-4.1A)
 0.24A 1ekjC-3ucnA:
21.6
1ekjD-3ucnA:
22.0		 1ekjC-3ucnA:
28.69
1ekjD-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		4 / 6 CYH A  47
ASP A  49
VAL A  71
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
AZI  A 229 (-4.1A)
 0.23A 1ekjC-3ucnA:
21.6
1ekjD-3ucnA:
22.0		 1ekjC-3ucnA:
28.69
1ekjD-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		4 / 7 CYH A  47
ASP A  49
HIS A 103
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
ZN  A 228 ( 3.3A)
AZI  A 229 (-4.1A)
 0.18A 1ekjE-3ucnA:
21.7
1ekjF-3ucnA:
21.6		 1ekjE-3ucnA:
28.69
1ekjF-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		4 / 8 CYH A  47
ASP A  49
VAL A  71
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
AZI  A 229 (-4.1A)
 0.28A 1ekjE-3ucnA:
21.7
1ekjF-3ucnA:
21.6		 1ekjE-3ucnA:
28.69
1ekjF-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 8 CYH A  47
ASP A  49
HIS A 103
CYH A 106
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
 0.13A 1ekjG-3ucnA:
21.7
1ekjH-3ucnA:
22.0		 1ekjG-3ucnA:
28.69
1ekjH-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 8 CYH A  47
ASP A  49
HIS A 103
CYH A 106
GLY A 107
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
 0.98A 1ekjG-3ucnA:
21.7
1ekjH-3ucnA:
22.0		 1ekjG-3ucnA:
28.69
1ekjH-3ucnA:
28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 6 CYH A  47
ASP A  49
VAL A  71
HIS A 103
CYH A 106
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
 0.28A 1ekjG-3ucnA:
21.7
1ekjH-3ucnA:
22.0		 1ekjG-3ucnA:
28.69
1ekjH-3ucnA:
28.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		10 / 10 CYH A  47
ASP A  49
VAL A  71
HIS A 103
CYH A 106
GLY A 107
ALA A 108
ALA A 111
TRP A 115
THR A 123
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
AZI  A 229 ( 4.6A)
None
None
None
 0.26A 3ucjA-3ucnA:
35.1		 3ucjA-3ucnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		3 / 3 GLN A  38
PHE A  66
TYR A  88
 AZI  A 230 (-3.9A)
AZI  A 230 (-4.6A)
AZI  A 230 ( 4.9A)
 0.37A 3ucjB-3ucnA:
35.0		 3ucjB-3ucnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		3 / 3 GLN A  38
PHE A  66
TYR A  88
 AZI  A 230 (-3.9A)
AZI  A 230 (-4.6A)
AZI  A 230 ( 4.9A)
 0.35A 3ucjA-3ucnA:
35.1		 3ucjA-3ucnA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		10 / 10 CYH A  47
ASP A  49
VAL A  71
HIS A 103
CYH A 106
GLY A 107
ALA A 108
ALA A 111
TRP A 115
THR A 123
 ZN  A 228 ( 2.3A)
AZI  A 229 (-4.2A)
None
ZN  A 228 ( 3.3A)
ZN  A 228 ( 2.3A)
AZI  A 229 (-4.1A)
AZI  A 229 ( 4.6A)
None
None
None
 0.30A 3ucjB-3ucnA:
35.0		 3ucjB-3ucnA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		5 / 12 LEU A  74
GLY A 112
ASN A 157
VAL A 133
ASN A  73
 None
 1.24A 5kbwB-3ucnA:
undetectable		 5kbwB-3ucnA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3ucn CARBONIC ANHYDRASE
(Coccomyxa
sp.
PA) 		4 / 7 HIS A 142
HIS A 116
ASP A 135
GLU A 132
 None
 1.38A 6mn4F-3ucnA:
undetectable		 6mn4F-3ucnA:
20.49