SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uel'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 ASP A 900
THR A 897
TYR A 718
HIS A 911
 None
 1.49A 2dysA-3uelA:
undetectable
2dysC-3uelA:
undetectable		 2dysA-3uelA:
19.74
2dysC-3uelA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 ASP A 900
THR A 897
TYR A 718
HIS A 911
 None
 1.47A 2eimA-3uelA:
undetectable
2eimC-3uelA:
undetectable		 2eimA-3uelA:
19.74
2eimC-3uelA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		5 / 12 GLY A 720
THR A 897
THR A 863
ALA A 862
HIS A 715
 None
 1.03A 2gluB-3uelA:
undetectable		 2gluB-3uelA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		5 / 12 ALA A 844
ILE A 820
VAL A 861
ALA A 862
ILE A 722
 None
None
None
None
A1R  A1001 (-4.2A)
 1.09A 2h42B-3uelA:
undetectable		 2h42B-3uelA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 8 MET A 910
LEU A 914
ARG A 930
PRO A 440
 None
 0.90A 2qd5B-3uelA:
undetectable		 2qd5B-3uelA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		5 / 12 TYR A 785
LEU A 675
SER A 622
ALA A 627
GLU A 624
 None
 1.31A 2vdmA-3uelA:
0.5
2vdmB-3uelA:
undetectable		 2vdmA-3uelA:
23.70
2vdmB-3uelA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 7 GLN A 831
GLY A 867
GLY A 873
ALA A 822
 None
A1R  A1001 (-2.9A)
None
A1R  A1001 ( 4.6A)
 0.84A 3fpjB-3uelA:
undetectable		 3fpjB-3uelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 7 THR A 768
TYR A 649
TYR A 652
ARG A 695
 None
 1.49A 3wipA-3uelA:
undetectable
3wipB-3uelA:
undetectable		 3wipA-3uelA:
17.65
3wipB-3uelA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 8 THR A 768
TYR A 649
TYR A 652
ARG A 695
 None
 1.49A 3wipB-3uelA:
undetectable
3wipC-3uelA:
undetectable		 3wipB-3uelA:
17.65
3wipC-3uelA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 LEU A 766
ALA A 633
LEU A 629
SER A 628
 None
 1.14A 4d7bB-3uelA:
undetectable		 4d7bB-3uelA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 5 ALA A 597
ILE A 535
LEU A 539
ASN A 632
 None
 0.89A 4g19A-3uelA:
undetectable		 4g19A-3uelA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		3 / 3 PHE A 676
THR A 637
LEU A 549
 None
 0.63A 4qztA-3uelA:
undetectable		 4qztA-3uelA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 7 PHE A 676
ILE A 553
LEU A 569
PHE A 661
 None
 0.69A 4uymA-3uelA:
undetectable		 4uymA-3uelA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 7 ASN A 656
PHE A 657
TRP A 564
PHE A 566
 None
 1.16A 4v32A-3uelA:
undetectable		 4v32A-3uelA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 7 ASN A 656
PHE A 657
TRP A 564
PHE A 566
 None
 1.14A 4v32B-3uelA:
0.0		 4v32B-3uelA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 ARG A 839
ARG A 737
ASP A 772
ASP A 821
 None
 1.38A 4xqeB-3uelA:
undetectable		 4xqeB-3uelA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		5 / 11 LEU A 714
ALA A 860
GLY A 726
ILE A 722
VAL A 716
 None
None
None
A1R  A1001 (-4.2A)
None
 1.15A 5kr2B-3uelA:
undetectable		 5kr2B-3uelA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 LEU A 766
ALA A 633
LEU A 629
SER A 628
 None
 1.10A 5l4iB-3uelA:
undetectable		 5l4iB-3uelA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 5 LEU A 630
VAL A 763
MET A 621
CYH A 604
 None
 1.42A 5te0A-3uelA:
undetectable		 5te0A-3uelA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		5 / 12 LEU A 630
MET A 621
VAL A 691
PHE A 693
THR A 768
 None
 1.25A 5w8aA-3uelA:
undetectable		 5w8aA-3uelA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Rattus
norvegicus) 		4 / 6 ASP A 733
VAL A 818
GLU A 751
ALA A 870
 None
None
A1R  A1001 (-4.2A)
A1R  A1001 (-3.8A)
 1.23A 6djzB-3uelA:
undetectable		 6djzB-3uelA:
17.47