SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 ASP A 456
PHE A 446
VAL A 435
 None
 0.71A 1kijB-3uemA:
undetectable		 1kijB-3uemA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 339
LEU A 272
PHE A 275
LYS A 276
ILE A 257
 None
 1.10A 1re7A-3uemA:
undetectable		 1re7A-3uemA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 369
VAL A 421
TRP A 407
 None
 0.94A 1w5uA-3uemA:
undetectable
1w5uB-3uemA:
undetectable		 1w5uA-3uemA:
3.50
1w5uB-3uemA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 421
TRP A 407
VAL A 369
 None
 0.98A 2izqC-3uemA:
undetectable
2izqD-3uemA:
undetectable		 2izqC-3uemA:
3.50
2izqD-3uemA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 LEU A 403
LEU A 443
ILE A 422
TYR A 414
PHE A 466
 None
 1.10A 2weyA-3uemA:
undetectable		 2weyA-3uemA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 5 PHE A 290
ILE A 301
ASN A 274
PHE A 240
 None
D1D  A2815 ( 4.3A)
None
D1D  A2815 ( 4.4A)
 1.35A 3octA-3uemA:
undetectable		 3octA-3uemA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 339
LEU A 272
PHE A 275
LYS A 276
ILE A 289
 None
None
None
None
D1D  A2815 (-4.2A)
 1.19A 3ql0A-3uemA:
undetectable		 3ql0A-3uemA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 10 ALA A 156
VAL A 204
GLY A 159
ILE A 186
VAL A 150
 None
 1.04A 4j5jB-3uemA:
undetectable		 4j5jB-3uemA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 339
PHE A 275
LYS A 276
ILE A 289
ILE A 257
 None
None
None
D1D  A2815 (-4.2A)
None
 1.07A 4kjkA-3uemA:
undetectable		 4kjkA-3uemA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.68A 4olbA-3uemA:
undetectable		 4olbA-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 ILE A 339
PHE A 275
LYS A 276
ILE A 289
ILE A 257
 None
None
None
D1D  A2815 (-4.2A)
None
 1.04A 4p3rA-3uemA:
undetectable		 4p3rA-3uemA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.71A 4w5nA-3uemA:
undetectable		 4w5nA-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.70A 4z4iA-3uemA:
undetectable		 4z4iA-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 10 GLY A 185
ALA A 146
ILE A 158
SER A 148
ALA A 145
 None
 1.19A 5eeuQ-3uemA:
undetectable
5eeuR-3uemA:
undetectable		 5eeuQ-3uemA:
12.29
5eeuR-3uemA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 10 GLY A 185
ALA A 146
ILE A 158
SER A 148
ALA A 145
 None
 1.19A 5eevQ-3uemA:
undetectable
5eevR-3uemA:
undetectable		 5eevQ-3uemA:
12.29
5eevR-3uemA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 10 GLY A 185
ALA A 146
ILE A 158
SER A 148
ALA A 145
 None
 1.19A 5eewQ-3uemA:
undetectable
5eewR-3uemA:
undetectable		 5eewQ-3uemA:
12.29
5eewR-3uemA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 6 ARG A 452
PHE A 446
GLU A 433
VAL A 432
 None
 1.35A 5h4dA-3uemA:
undetectable		 5h4dA-3uemA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		3 / 3 VAL A 388
ALA A 448
PHE A 445
 None
 0.66A 5js1A-3uemA:
undetectable		 5js1A-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		5 / 12 PHE A 445
GLY A 477
ILE A 420
PHE A 389
GLY A 459
 None
 0.99A 5veuH-3uemA:
undetectable		 5veuH-3uemA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3uem PROTEIN
DISULFIDE-ISOMERASE
(Homo
sapiens) 		4 / 6 PHE A 377
LEU A 372
ALA A 381
GLN A 358
 None
 0.99A 6b89B-3uemA:
undetectable		 6b89B-3uemA:
13.12