SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 621
LEU A 598
GLY A 658
THR A 614
LEU A 633
 None
SCN  A 801 ( 3.9A)
None
SCN  A 801 (-3.9A)
None
 1.06A 1liiA-3uenA:
undetectable		 1liiA-3uenA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 582
ILE A 575
VAL A 596
VAL A 611
PHE A 563
 GOL  A 802 (-4.8A)
None
None
None
None
 1.14A 2ygpA-3uenA:
undetectable		 2ygpA-3uenA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 648
HIS A 694
PRO A 645
GLY A 672
LEU A 671
 None
 1.29A 3j6pB-3uenA:
undetectable		 3j6pB-3uenA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 558
ASP A 592
ALA A 579
SER A 557
GLY A 580
 None
 1.24A 4xp1A-3uenA:
undetectable		 4xp1A-3uenA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A 622
THR A 624
THR A 618
 None
 0.83A 5aoxE-3uenA:
undetectable		 5aoxE-3uenA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3uen DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 648
HIS A 694
PRO A 645
GLY A 672
LEU A 671
 None
 1.28A 5ogcB-3uenA:
undetectable		 5ogcB-3uenA:
18.14