SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uf0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 10 ALA A  26
ASN A  91
LEU A 184
VAL A 244
ILE A 141
None
NAP  A 274 (-3.2A)
None
None
NAP  A 274 (-4.3A)
1.26A 1claA-3uf0A:
undetectable
1claA-3uf0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
4 / 7 ARG A 109
THR A 113
VAL A 114
ALA A 155
None
None
NAP  A 274 ( 4.7A)
None
0.64A 1fo4B-3uf0A:
undetectable
1fo4B-3uf0A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 12 ALA A 185
GLY A 187
ILE A 141
ALA A 183
SER A 146
None
None
NAP  A 274 (-4.3A)
None
None
1.01A 1ve3B-3uf0A:
6.7
1ve3B-3uf0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 12 ILE A  21
ILE A  25
GLY A  16
ALA A  64
VAL A  13
NAP  A 274 (-3.7A)
None
NAP  A 274 (-3.8A)
None
None
1.21A 2yvlC-3uf0A:
7.1
2yvlC-3uf0A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
4 / 8 ILE A 141
ASN A 115
SER A 159
SER A 143
NAP  A 274 (-4.3A)
None
None
NAP  A 274 (-3.5A)
1.15A 2zw9B-3uf0A:
5.4
2zw9B-3uf0A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
3 / 3 ARG A 109
ILE A  94
THR A  15
None
NAP  A 274 (-4.9A)
None
0.65A 3ia4D-3uf0A:
undetectable
3ia4D-3uf0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 11 ALA A  72
VAL A  62
GLY A  40
LEU A  79
LEU A 122
None
None
NAP  A 274 ( 4.5A)
None
None
1.04A 3sm2B-3uf0A:
undetectable
3sm2B-3uf0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
4 / 5 SER A 143
ILE A  21
TYR A 156
GLY A 187
NAP  A 274 (-3.5A)
NAP  A 274 (-3.7A)
NAP  A 274 (-4.7A)
None
0.94A 3uboB-3uf0A:
6.8
3uboB-3uf0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 11 ALA A  59
ALA A  26
GLY A  56
GLY A  55
ALA A  53
None
1.02A 5lf3K-3uf0A:
undetectable
5lf3L-3uf0A:
undetectable
5lf3K-3uf0A:
26.12
5lf3L-3uf0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 11 ALA A  59
ALA A  26
GLY A  56
GLY A  55
ALA A  53
None
1.03A 5lf3Y-3uf0A:
undetectable
5lf3Z-3uf0A:
undetectable
5lf3Y-3uf0A:
26.12
5lf3Z-3uf0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
3uf0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Beutenbergia
cavernae)
5 / 12 LEU A  79
VAL A  75
PHE A 126
THR A  15
GLY A  16
None
None
None
None
NAP  A 274 (-3.8A)
1.15A 6brdA-3uf0A:
5.2
6brdA-3uf0A:
15.38