SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ufa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A   6
ALA A  10
ALA A  20
THR A  25
 None
 0.86A 1ie4B-3ufaA:
undetectable
1ie4D-3ufaA:
undetectable		 1ie4B-3ufaA:
23.23
1ie4D-3ufaA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.67A 1p7lD-3ufaA:
undetectable		 1p7lD-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.67A 1p7lC-3ufaA:
undetectable		 1p7lC-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.66A 1rg9B-3ufaA:
undetectable		 1rg9B-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.68A 1rg9A-3ufaA:
undetectable		 1rg9A-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.67A 1rg9D-3ufaA:
undetectable		 1rg9D-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.67A 1rg9C-3ufaA:
undetectable		 1rg9C-3ufaA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		3 / 3 LEU A 169
HIS A  39
ILE A  40
 VPF  A 201 (-4.3A)
VPF  A 201 (-3.8A)
None
 0.68A 1s9pB-3ufaA:
undetectable		 1s9pB-3ufaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 ILE A 198
VAL A  27
LEU A 165
PHE A 186
ALA A  80
 None
 1.40A 2jj8C-3ufaA:
undetectable		 2jj8C-3ufaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 9 ALA A 171
SER A 154
GLY A 152
SER A 178
ALA A 149
 VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
VPF  A 201 (-3.3A)
VPF  A 201 ( 4.7A)
VPF  A 201 (-3.4A)
 1.46A 2vh3A-3ufaA:
undetectable		 2vh3A-3ufaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 6 LEU A 169
SER A 154
THR A  25
VAL A  18
 VPF  A 201 (-4.3A)
VPF  A 201 (-1.7A)
None
None
 1.03A 3d2tB-3ufaA:
undetectable		 3d2tB-3ufaA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLY A 167
ILE A 194
VAL A  35
VAL A  27
 None
 0.79A 3fi0B-3ufaA:
undetectable		 3fi0B-3ufaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLY A 167
ILE A 194
VAL A  35
VAL A  27
 None
 0.68A 3fi0G-3ufaA:
undetectable		 3fi0G-3ufaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLY A 167
ILE A 194
VAL A  35
VAL A  27
 None
 0.72A 3fi0Q-3ufaA:
undetectable		 3fi0Q-3ufaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.81A 3keeB-3ufaA:
13.0		 3keeB-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3keeC-3ufaA:
12.4		 3keeC-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3keeD-3ufaA:
12.8		 3keeD-3ufaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.48A 3p97A-3ufaA:
undetectable		 3p97A-3ufaA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3sueA-3ufaA:
11.8		 3sueA-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.83A 3sueC-3ufaA:
11.4		 3sueC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 11 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.88A 3sufC-3ufaA:
11.1		 3sufC-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.78A 3sufD-3ufaA:
11.5		 3sufD-3ufaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.47A 4ctkA-3ufaA:
undetectable		 4ctkA-3ufaA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 6 LYS A 191
ILE A 194
VAL A  35
LEU A  79
 None
 1.00A 4em2A-3ufaA:
undetectable		 4em2A-3ufaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.66A 4kttB-3ufaA:
undetectable		 4kttB-3ufaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.69A 4kttD-3ufaA:
undetectable		 4kttD-3ufaA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		3 / 3 THR A  36
ASN A  49
PHE A  47
 None
 0.83A 4pd9A-3ufaA:
undetectable		 4pd9A-3ufaA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		3 / 3 THR A 141
THR A 187
PHE A 193
 None
 0.79A 5cxvA-3ufaA:
undetectable		 5cxvA-3ufaA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.45A 5e9qA-3ufaA:
undetectable		 5e9qA-3ufaA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.45A 5ec8A-3ufaA:
undetectable		 5ec8A-3ufaA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.45A 5ehgA-3ufaA:
undetectable		 5ehgA-3ufaA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.49A 5njvB-3ufaA:
undetectable		 5njvB-3ufaA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 8 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.77A 5t8sA-3ufaA:
undetectable		 5t8sA-3ufaA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 GLY A 167
GLY A  26
GLY A 155
VAL A  51
ILE A  34
 None
 0.95A 5vimA-3ufaA:
undetectable		 5vimA-3ufaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 GLY A 167
GLY A  26
GLY A 155
VAL A  51
ILE A  34
 None
 0.95A 5vimB-3ufaA:
undetectable		 5vimB-3ufaA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		6 / 12 GLY A 167
GLY A  26
GLY A 155
THR A  25
VAL A  51
ILE A  34
 None
 1.50A 5wz2B-3ufaA:
undetectable		 5wz2B-3ufaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 GLY A 167
GLY A  26
GLY A 155
VAL A  51
ILE A  34
 None
 0.89A 5wz2C-3ufaA:
undetectable		 5wz2C-3ufaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 5 HIS A  39
ALA A 171
SER A 154
GLY A 155
 VPF  A 201 (-3.8A)
VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
None
 1.08A 5yodB-3ufaA:
10.7		 5yodB-3ufaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 5 HIS A  39
ALA A 171
SER A 154
GLY A 155
 VPF  A 201 (-3.8A)
VPF  A 201 (-4.9A)
VPF  A 201 (-1.7A)
None
 1.25A 5yodD-3ufaA:
10.7		 5yodD-3ufaA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		5 / 12 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.80A 6c2mC-3ufaA:
11.7		 6c2mC-3ufaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3ufa SERINE PROTEASE SPLA
(Staphylococcus
aureus) 		4 / 7 GLU A 164
ILE A 166
ASP A 111
ILE A 135
 None
 0.76A 6fbnA-3ufaA:
undetectable		 6fbnA-3ufaA:
22.86