SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ufx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 8 ALA B 213
LEU B 209
LEU B 115
LEU B 104
 None
 0.90A 1dvtA-3ufxB:
undetectable
1dvtB-3ufxB:
undetectable		 1dvtA-3ufxB:
16.05
1dvtB-3ufxB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 11 PHE B 147
ALA B 152
LEU B 172
LEU B 192
ALA B 159
 None
 1.14A 1h9zA-3ufxB:
undetectable		 1h9zA-3ufxB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		3 / 3 ARG B 325
TYR B 290
LYS B 294
 None
 0.76A 1uujB-3ufxB:
undetectable		 1uujB-3ufxB:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 6 ILE B 280
ALA B 284
THR B 314
ALA B 341
 None
 0.96A 1w0gA-3ufxB:
undetectable		 1w0gA-3ufxB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 5 ALA B 178
TYR B 179
ALA B 174
TYR B 176
 None
 1.02A 1xl6A-3ufxB:
undetectable
1xl6B-3ufxB:
undetectable		 1xl6A-3ufxB:
21.03
1xl6B-3ufxB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR B 370
GLY B 251
GLY B 304
ASP B 279
ILE B 280
 None
 1.19A 2b25B-3ufxB:
undetectable		 2b25B-3ufxB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU B 104
LEU B 115
ILE B 207
LEU B 168
VAL B  17
 None
 1.20A 2hrcA-3ufxB:
3.7		 2hrcA-3ufxB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 LEU B 104
LEU B 115
ILE B 207
LEU B 168
VAL B  17
 None
 1.17A 2hrcB-3ufxB:
5.5		 2hrcB-3ufxB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 4 ALA B 178
TYR B 179
ALA B 174
TYR B 176
 None
 1.05A 2wlkA-3ufxB:
undetectable
2wlkB-3ufxB:
undetectable		 2wlkA-3ufxB:
21.03
2wlkB-3ufxB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR B 263
ILE B 252
GLY B 256
THR B 314
ASN B 308
 None
 1.05A 2y7hB-3ufxB:
undetectable		 2y7hB-3ufxB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 THR B 263
ILE B 252
GLY B 256
THR B 314
ASN B 308
 None
 1.05A 2y7hC-3ufxB:
undetectable		 2y7hC-3ufxB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE B 200
VAL B 194
LYS B  98
LEU B 117
LEU B 175
 None
 1.06A 3em0B-3ufxB:
undetectable		 3em0B-3ufxB:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 5 VAL B 288
ILE B 253
TYR B 360
MET B 359
 None
 1.47A 3gvuA-3ufxB:
undetectable		 3gvuA-3ufxB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		3 / 3 GLU B 188
ASP B 204
ASP B 124
 None
GDP  B 398 ( 3.5A)
None
 0.59A 3jb2A-3ufxB:
undetectable		 3jb2A-3ufxB:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 GLY B 283
GLY B 282
ILE B 307
ASN B 291
VAL B 288
 None
 0.96A 3nk7A-3ufxB:
3.6		 3nk7A-3ufxB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE B 207
ALA B 178
LEU B 214
MET B   1
LEU B 220
 None
 1.16A 3s79A-3ufxB:
undetectable		 3s79A-3ufxB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 10 VAL B 289
ILE B 309
GLY B 311
ILE B 313
VAL B 288
 None
 1.02A 3t3cB-3ufxB:
undetectable		 3t3cB-3ufxB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 8 VAL B 296
TYR B 243
VAL B 302
ILE B 252
 None
 1.16A 4aftD-3ufxB:
undetectable
4aftE-3ufxB:
undetectable		 4aftD-3ufxB:
17.33
4aftE-3ufxB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 GLY B 248
ASN B 249
ASP B 299
ASP B 247
ASN B 276
 None
 1.26A 4pooB-3ufxB:
2.1		 4pooB-3ufxB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 7 ILE B 309
GLU B 345
GLY B 312
GLY B 311
 None
 0.87A 5a06B-3ufxB:
undetectable		 5a06B-3ufxB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		4 / 7 ILE B 309
GLU B 345
GLY B 312
GLY B 311
 None
 0.87A 5a06F-3ufxB:
5.0		 5a06F-3ufxB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 12 ILE B 207
ALA B 178
LEU B 214
MET B   1
LEU B 220
 None
 1.16A 5jkvA-3ufxB:
undetectable		 5jkvA-3ufxB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ufx SUCCINYL-COA
SYNTHETASE BETA
SUBUNIT
(Thermus
aquaticus) 		5 / 10 LEU B 278
ILE B 253
GLY B 254
GLY B 256
ALA B 292
 None
 0.90A 5o96C-3ufxB:
2.9
5o96D-3ufxB:
3.5		 5o96C-3ufxB:
24.69
5o96D-3ufxB:
24.69