SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ugk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  21
ALA A  19
GLU A  11
LEU A  76
ARG A   9
 None
 1.23A 1g50A-3ugkA:
undetectable		 1g50A-3ugkA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  21
ALA A  19
GLU A  11
LEU A  76
ARG A   9
 None
 1.32A 1qktA-3ugkA:
undetectable		 1qktA-3ugkA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 140
ALA A 209
VAL A 196
GLY A 147
ILE A 316
ILE A 198
 None
 1.44A 1rl8A-3ugkA:
undetectable		 1rl8A-3ugkA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  19
GLU A  11
LEU A  76
ARG A   9
LEU A 341
 None
 1.14A 1s9pA-3ugkA:
undetectable		 1s9pA-3ugkA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  46
TYR A  51
ARG A 327
VAL A  26
 None
 1.29A 1wu8A-3ugkA:
3.7
1wu8C-3ugkA:
3.6		 1wu8A-3ugkA:
23.79
1wu8C-3ugkA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.99A 2aquA-3ugkA:
undetectable		 2aquA-3ugkA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 140
ALA A 209
VAL A 196
GLY A 147
ILE A 316
ILE A 198
 None
 1.47A 2o4kB-3ugkA:
undetectable		 2o4kB-3ugkA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.88A 2pxcA-3ugkA:
2.1		 2pxcA-3ugkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.99A 2pymA-3ugkA:
undetectable		 2pymA-3ugkA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.98A 2pymB-3ugkA:
undetectable		 2pymB-3ugkA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 140
ALA A 209
VAL A 196
GLY A 147
ILE A 316
ILE A 198
 None
 1.42A 2qakA-3ugkA:
undetectable		 2qakA-3ugkA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.93A 2r5qD-3ugkA:
undetectable		 2r5qD-3ugkA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 305
VAL A 275
ASP A 277
SER A 317
 None
 1.33A 2x45A-3ugkA:
undetectable		 2x45A-3ugkA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 305
VAL A 275
ASP A 277
SER A 317
 None
 1.31A 2x45C-3ugkA:
undetectable		 2x45C-3ugkA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 140
ALA A 209
VAL A 148
GLY A 147
ILE A 316
ILE A 198
 None
 1.30A 3ekqA-3ugkA:
undetectable		 3ekqA-3ugkA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.97A 3ekyA-3ugkA:
undetectable		 3ekyA-3ugkA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 140
ALA A 209
GLY A 147
ILE A 316
ILE A 198
 None
 0.97A 3el1A-3ugkA:
undetectable		 3el1A-3ugkA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 144
GLY A 208
SER A 205
ASP A 211
LEU A 212
 None
 1.36A 3ou6D-3ugkA:
undetectable		 3ou6D-3ugkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.90A 3p97A-3ugkA:
undetectable		 3p97A-3ugkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		4 / 8 LEU A   8
ALA A  19
SER A  44
SER A  41
 None
 1.03A 3rodA-3ugkA:
undetectable		 3rodA-3ugkA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 LYS A  13
PRO A  14
LEU A  15
 None
 0.69A 3tpxE-3ugkA:
undetectable		 3tpxE-3ugkA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  21
ALA A  19
THR A  25
PHE A  46
 None
 1.38A 3vasB-3ugkA:
undetectable		 3vasB-3ugkA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 165
ASN A 299
ASP A 182
ARG A 149
HIS A 157
 None
 1.13A 3wemA-3ugkA:
undetectable		 3wemA-3ugkA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 165
ASN A 299
ASP A 182
ARG A 149
HIS A 157
 None
 1.13A 3wenA-3ugkA:
undetectable		 3wenA-3ugkA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 165
ASN A 299
ASP A 182
ARG A 149
HIS A 157
 None
 1.12A 3weoA-3ugkA:
undetectable		 3weoA-3ugkA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 11 THR A  25
LEU A   6
PHE A  34
SER A 334
VAL A 352
 None
 1.48A 4claA-3ugkA:
undetectable		 4claA-3ugkA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.86A 4ctjA-3ugkA:
undetectable		 4ctjA-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 4ctjC-3ugkA:
2.4		 4ctjC-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 4ctkA-3ugkA:
undetectable		 4ctkA-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.85A 4ctkC-3ugkA:
2.3		 4ctkC-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 271
THR A 274
TRP A 151
 None
 1.14A 4d7hA-3ugkA:
undetectable		 4d7hA-3ugkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 136
SER A 207
ALA A 142
VAL A 278
VAL A 276
 None
 0.95A 4htfA-3ugkA:
2.6		 4htfA-3ugkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 136
SER A 207
ALA A 142
VAL A 278
VAL A 276
 None
 0.96A 4htfB-3ugkA:
2.7		 4htfB-3ugkA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 331
LEU A 121
LEU A  21
THR A  22
THR A  25
 None
 1.16A 4lu3A-3ugkA:
undetectable		 4lu3A-3ugkA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 206
GLY A 203
LEU A 212
ALA A 142
 None
 0.96A 4uciA-3ugkA:
undetectable		 4uciA-3ugkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 206
GLY A 203
LEU A 212
ALA A 142
 None
 0.96A 4uciB-3ugkA:
undetectable		 4uciB-3ugkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 271
THR A 274
TRP A 151
 None
 1.17A 4ug5A-3ugkA:
undetectable		 4ug5A-3ugkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 271
THR A 274
TRP A 151
 None
 1.17A 4uglA-3ugkA:
undetectable		 4uglA-3ugkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 VAL A  26
TYR A  51
ALA A  54
 None
 0.55A 4ybnA-3ugkA:
undetectable		 4ybnA-3ugkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  21
ALA A  19
GLU A  11
LEU A  76
ARG A   9
 None
 1.20A 5dxbA-3ugkA:
undetectable		 5dxbA-3ugkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  21
ALA A  19
GLU A  11
LEU A  76
ARG A   9
 None
 1.23A 5dxeB-3ugkA:
undetectable		 5dxeB-3ugkA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 5e9qA-3ugkA:
undetectable		 5e9qA-3ugkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.85A 5e9qC-3ugkA:
undetectable		 5e9qC-3ugkA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 5ec8C-3ugkA:
undetectable		 5ec8C-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.86A 5ehgA-3ugkA:
undetectable		 5ehgA-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.89A 5ehgC-3ugkA:
undetectable		 5ehgC-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.86A 5eifA-3ugkA:
2.1		 5eifA-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.85A 5eifC-3ugkA:
undetectable		 5eifC-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.86A 5eiwA-3ugkA:
undetectable		 5eiwA-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.88A 5ekxB-3ugkA:
2.3		 5ekxB-3ugkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 271
THR A 274
TRP A 151
 None
 1.13A 5g6cA-3ugkA:
undetectable		 5g6cA-3ugkA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.93A 5ikmA-3ugkA:
undetectable		 5ikmA-3ugkA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.89A 5kqrA-3ugkA:
undetectable		 5kqrA-3ugkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.90A 5kqsA-3ugkA:
2.1		 5kqsA-3ugkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.88A 5m5bA-3ugkA:
undetectable		 5m5bA-3ugkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 5njvA-3ugkA:
undetectable		 5njvA-3ugkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.82A 5njvB-3ugkA:
undetectable		 5njvB-3ugkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.93A 5njvC-3ugkA:
undetectable		 5njvC-3ugkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.93A 5vimA-3ugkA:
undetectable		 5vimA-3ugkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.94A 5vimB-3ugkA:
undetectable		 5vimB-3ugkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.87A 5wz1B-3ugkA:
undetectable		 5wz1B-3ugkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.88A 5wz2A-3ugkA:
undetectable		 5wz2A-3ugkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.88A 5wz2B-3ugkA:
undetectable		 5wz2B-3ugkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 140
GLY A 200
GLY A 203
GLY A 208
ILE A 250
 None
 0.83A 5wz2C-3ugkA:
undetectable		 5wz2C-3ugkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 257
ILE A 256
PHE A 259
SER A 232
GLY A 234
 None
 0.97A 6awoA-3ugkA:
undetectable		 6awoA-3ugkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3ugk SACCHAROPINE
DEHYDROGENASE [NAD+,
L-LYSINE-FORMING]
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 257
ILE A 256
PHE A 259
SER A 232
GLY A 234
 None
 0.98A 6awqA-3ugkA:
undetectable		 6awqA-3ugkA:
20.33