SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.35A 1fk9A-3uitA:
undetectable		 1fk9A-3uitA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.32A 1ikwA-3uitA:
undetectable		 1ikwA-3uitA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 9 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.49A 1lwfA-3uitA:
undetectable		 1lwfA-3uitA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 8 PHE A 117
LEU A  42
LEU A 108
LEU A  89
 None
 0.97A 2bfpB-3uitA:
undetectable		 2bfpB-3uitA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 6 LEU A  13
GLN A  14
LEU A  42
PHE A  38
 None
 1.02A 2zxwP-3uitA:
undetectable
2zxwW-3uitA:
undetectable		 2zxwP-3uitA:
21.99
2zxwW-3uitA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 6 LEU A  13
GLN A  14
LEU A  42
PHE A  38
 None
 0.95A 3ag1C-3uitA:
undetectable
3ag1J-3uitA:
undetectable		 3ag1C-3uitA:
21.99
3ag1J-3uitA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.42A 3lp1A-3uitA:
undetectable		 3lp1A-3uitA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 LEU A  85
HIS A  91
LEU A  35
THR A  29
LEU A  80
 None
 1.25A 3okxB-3uitA:
undetectable		 3okxB-3uitA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 8 GLY A  27
ILE A  92
ASP A  98
SER A 101
 None
 0.73A 3pwwA-3uitA:
undetectable		 3pwwA-3uitA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 5 LEU A  19
LEU A  16
LEU A 107
SER A 106
 None
 1.00A 3vhuA-3uitA:
undetectable		 3vhuA-3uitA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 11 LEU A 237
VAL A 154
LEU A 155
LEU A 147
LEU A 170
 None
 1.09A 4or0B-3uitA:
undetectable		 4or0B-3uitA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 ALA A 216
LEU A 241
LEU A 179
SER A 247
LEU A 197
 None
None
None
ACT  A 272 ( 4.3A)
None
 1.18A 4q0dC-3uitA:
undetectable		 4q0dC-3uitA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 12 ALA A 216
LEU A 241
LEU A 179
SER A 247
LEU A 197
 None
None
None
ACT  A 272 ( 4.3A)
None
 1.18A 4q0dD-3uitA:
undetectable		 4q0dD-3uitA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 11 LEU A 166
LEU A 170
GLU A 221
ALA A 236
LEU A 237
 None
 1.19A 4wg0H-3uitA:
undetectable
4wg0I-3uitA:
undetectable
4wg0J-3uitA:
undetectable		 4wg0H-3uitA:
4.25
4wg0I-3uitA:
4.25
4wg0J-3uitA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.42A 6bsgA-3uitA:
undetectable		 6bsgA-3uitA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.30A 6bsiA-3uitA:
2.1		 6bsiA-3uitA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		5 / 10 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.39A 6bsjA-3uitA:
undetectable		 6bsjA-3uitA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B
(Homo
sapiens;
Mus
musculus;
Rattus
norvegicus) 		4 / 4 ILE A 175
LEU A 197
HIS A 182
ALA A 181
 None
 0.95A 6ck2C-3uitA:
undetectable
6ck2D-3uitA:
undetectable		 6ck2C-3uitA:
4.26
6ck2D-3uitA:
7.72