SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 GLU A 343
ARG A 346
ARG A 347
GLU A 156
 None
 0.92A 1cmaA-3uk1A:
undetectable
1cmaB-3uk1A:
undetectable		 1cmaA-3uk1A:
9.71
1cmaB-3uk1A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 GLY A 653
GLY A 654
TRP A 645
VAL A 608
 None
 0.77A 1dbbH-3uk1A:
undetectable
1dbbL-3uk1A:
undetectable		 1dbbH-3uk1A:
16.54
1dbbL-3uk1A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 149
LEU A 448
VAL A 478
ALA A 147
SER A 440
 None
 1.15A 1eqbB-3uk1A:
undetectable		 1eqbB-3uk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 149
LEU A 448
VAL A 478
ALA A 147
SER A 440
 None
 1.15A 1eqbC-3uk1A:
undetectable		 1eqbC-3uk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 149
LEU A 448
VAL A 478
ALA A 147
SER A 440
 None
 1.15A 1eqbD-3uk1A:
undetectable		 1eqbD-3uk1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 THR A 126
PRO A 127
GLY A 128
LEU A 107
 None
 0.49A 1h4oG-3uk1A:
undetectable		 1h4oG-3uk1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 ASN A 158
ALA A 154
ASP A 166
GLU A 150
 None
 1.24A 1lqtA-3uk1A:
2.9
1lqtB-3uk1A:
2.3		 1lqtA-3uk1A:
21.36
1lqtB-3uk1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 ASN A 158
ALA A 154
ASP A 166
GLU A 150
 None
 1.23A 1lquA-3uk1A:
3.3
1lquB-3uk1A:
undetectable		 1lquA-3uk1A:
21.36
1lquB-3uk1A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 PHE A 671
SER A 543
SER A 586
ALA A 519
THR A 376
 None
 1.37A 1m4dA-3uk1A:
undetectable		 1m4dA-3uk1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 ALA A 527
VAL A 532
TRP A 356
 None
 0.88A 1micA-3uk1A:
undetectable
1micB-3uk1A:
undetectable		 1micA-3uk1A:
3.67
1micB-3uk1A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 427
VAL A 415
LEU A 148
LEU A 446
TYR A 452
 None
 1.40A 1pbcA-3uk1A:
undetectable		 1pbcA-3uk1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 7 LEU A 387
PHE A 542
VAL A 515
SER A 538
 None
 1.10A 1wrlA-3uk1A:
undetectable
1wrlB-3uk1A:
undetectable		 1wrlA-3uk1A:
8.93
1wrlB-3uk1A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 6 SER A  23
ALA A  22
THR A  25
ASN A  29
 None
 1.05A 1yvpB-3uk1A:
3.1		 1yvpB-3uk1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 11 VAL A 447
ASN A 142
PHE A 482
ALA A 469
SER A 466
 None
 1.40A 2ij7A-3uk1A:
undetectable		 2ij7A-3uk1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 VAL A 447
ASN A 142
PHE A 482
ALA A 469
SER A 466
 None
 1.41A 2ij7D-3uk1A:
undetectable		 2ij7D-3uk1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 VAL A 447
ASN A 142
PHE A 482
ALA A 469
SER A 466
 None
 1.38A 2ij7F-3uk1A:
0.0		 2ij7F-3uk1A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 ILE A 430
HIS A 429
LEU A 395
GLY A 456
 None
 0.80A 2vdbA-3uk1A:
undetectable		 2vdbA-3uk1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 7 THR A 126
PRO A 127
GLY A 128
LEU A 107
 None
 0.51A 2vl2B-3uk1A:
undetectable		 2vl2B-3uk1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 4 ALA A 335
TYR A 337
ALA A 331
TYR A 333
 None
 1.22A 2wlkA-3uk1A:
undetectable
2wlkB-3uk1A:
undetectable		 2wlkA-3uk1A:
18.17
2wlkB-3uk1A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 4 TYR A 100
LEU A 102
LEU A  95
HIS A  67
 None
 1.16A 2x7hB-3uk1A:
2.0		 2x7hB-3uk1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 VAL A 415
ILE A 430
LEU A 198
GLY A 145
ALA A 147
 None
 1.19A 2xf3A-3uk1A:
undetectable		 2xf3A-3uk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 9 VAL A 415
ILE A 430
LEU A 198
GLY A 145
ALA A 147
 None
 1.19A 2xf3B-3uk1A:
undetectable		 2xf3B-3uk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 9 VAL A 415
ILE A 430
LEU A 198
GLY A 145
ALA A 147
 None
 1.21A 2xfsB-3uk1A:
undetectable		 2xfsB-3uk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 9 VAL A 415
ILE A 430
LEU A 198
GLY A 145
ALA A 147
 None
 1.19A 2xh9B-3uk1A:
undetectable		 2xh9B-3uk1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 LEU A 296
SER A  93
GLY A  48
PRO A  47
 None
 0.82A 3hcrA-3uk1A:
2.6		 3hcrA-3uk1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 THR A 458
PHE A 459
ARG A 377
LEU A 406
 None
None
SO4  A 691 (-3.1A)
None
 1.16A 3qelC-3uk1A:
4.0		 3qelC-3uk1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 579
ALA A 605
VAL A 566
MET A 610
LEU A 628
 None
 1.03A 3s79A-3uk1A:
undetectable		 3s79A-3uk1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 ASN A 431
ALA A 414
ARG A 416
 None
 0.87A 3tj7C-3uk1A:
undetectable
3tj7D-3uk1A:
undetectable		 3tj7C-3uk1A:
12.38
3tj7D-3uk1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 4 ASP A 514
ASP A 614
GLY A 563
THR A 584
 None
 1.32A 3tl9B-3uk1A:
undetectable		 3tl9B-3uk1A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 414
GLY A 396
TYR A 452
ALA A 442
ASN A 431
 None
 1.20A 3tm4A-3uk1A:
3.7		 3tm4A-3uk1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 LEU A 201
MET A  53
PHE A  80
ASN A  84
 None
None
None
OCS  A 177 ( 4.2A)
 1.29A 3uq6A-3uk1A:
undetectable		 3uq6A-3uk1A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 6 GLY A 396
GLY A 397
ASN A 431
ILE A 384
 None
 0.98A 4fglD-3uk1A:
2.8		 4fglD-3uk1A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 PRO A 121
TYR A  92
GLY A  87
 None
 0.72A 4g2zA-3uk1A:
undetectable		 4g2zA-3uk1A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ8_A_ASDA602_1
(CYTOCHROME P450 19A1)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 10 ILE A 579
ALA A 605
VAL A 566
MET A 610
LEU A 628
 None
 1.06A 4kq8A-3uk1A:
undetectable		 4kq8A-3uk1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 LEU A  90
ILE A  31
ARG A  32
 None
 0.64A 4mk4B-3uk1A:
3.3		 4mk4B-3uk1A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_2
(ANDROGEN RECEPTOR)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 4 ASN A 109
MET A  89
LEU A 102
HIS A  96
 None
 1.31A 4oktA-3uk1A:
0.0		 4oktA-3uk1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 GLU A 185
GLY A 438
ALA A 469
ALA A 141
ASN A 142
 None
 1.12A 4pclB-3uk1A:
2.2		 4pclB-3uk1A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 517
THR A 642
TRP A 645
 None
 1.25A 4uglA-3uk1A:
undetectable		 4uglA-3uk1A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 6 LEU A 513
ALA A 473
LEU A 470
VAL A 447
 None
 1.15A 5a6iA-3uk1A:
undetectable		 5a6iA-3uk1A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 THR A 553
ASP A 554
ALA A 555
 None
 0.10A 5g5gB-3uk1A:
undetectable		 5g5gB-3uk1A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 ALA A 186
GLY A 438
GLY A 181
GLY A 145
LEU A 173
 None
None
None
None
OCS  A 177 ( 4.1A)
 0.86A 5gwxA-3uk1A:
2.9		 5gwxA-3uk1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 181
ALA A 469
LEU A 470
ALA A 186
GLY A 438
 None
 0.87A 5jglB-3uk1A:
2.3		 5jglB-3uk1A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 579
ALA A 605
VAL A 566
MET A 610
LEU A 628
 None
 1.03A 5jkvA-3uk1A:
undetectable		 5jkvA-3uk1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 430
LEU A 189
SER A 466
GLY A 456
GLY A 397
 None
 1.15A 5l6eA-3uk1A:
undetectable		 5l6eA-3uk1A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 8 THR A 192
GLY A 191
GLY A 229
ALA A 227
 None
 0.67A 5vw5A-3uk1A:
undetectable		 5vw5A-3uk1A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 7 ASP A 203
ASP A 175
GLY A 176
ASN A  84
 None
None
OCS  A 177 ( 2.4A)
OCS  A 177 ( 4.2A)
 1.04A 5x7pA-3uk1A:
undetectable		 5x7pA-3uk1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 PRO A 611
GLY A 563
TYR A 565
VAL A 526
 None
 1.25A 5x80C-3uk1A:
undetectable
5x80D-3uk1A:
undetectable		 5x80C-3uk1A:
13.64
5x80D-3uk1A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 SER A 466
ILE A 384
LEU A 507
PHE A 542
LEU A 460
 None
 1.29A 6a93A-3uk1A:
undetectable		 6a93A-3uk1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 PRO A 135
VAL A 472
GLY A 128
VAL A  81
 None
 1.09A 6ak3B-3uk1A:
undetectable		 6ak3B-3uk1A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 4 VAL A 213
GLY A 206
ASP A 204
ASP A 203
 None
 1.12A 6cjkC-3uk1A:
undetectable		 6cjkC-3uk1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		3 / 3 PHE A 549
ARG A 552
ALA A 525
 None
 0.93A 6ecfB-3uk1A:
undetectable		 6ecfB-3uk1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		4 / 5 ILE A 637
LEU A 590
ARG A 606
LEU A 598
 None
 0.91A 6nmpN-3uk1A:
1.5
6nmpW-3uk1A:
undetectable		 6nmpN-3uk1A:
22.10
6nmpW-3uk1A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3uk1 TRANSKETOLASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 540
ILE A 481
GLY A 397
ILE A 443
ALA A 442
 None
 1.20A 6qxsD-3uk1A:
undetectable		 6qxsD-3uk1A:
17.93