SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 HIS A  30
GLY A  32
GLY A 144
ASP A 147
VAL A 173
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
AMP  A 280 (-3.9A)
0.93A 1ffyA-3uk2A:
2.5
1ffyA-3uk2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
3 / 3 ARG A 184
ARG A  69
ARG A 118
MLT  A 284 (-3.1A)
None
MLT  A 284 (-3.3A)
0.81A 1l7fA-3uk2A:
undetectable
1l7fA-3uk2A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
3 / 3 ARG A 184
ARG A  69
ARG A 118
MLT  A 284 (-3.1A)
None
MLT  A 284 (-3.3A)
0.84A 1l7hA-3uk2A:
undetectable
1l7hA-3uk2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 11 HIS A  30
GLY A  32
HIS A  33
GLY A 144
ASP A 147
VAL A 173
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
AMP  A 280 (-3.9A)
0.83A 1pg2A-3uk2A:
undetectable
1pg2A-3uk2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 12 HIS A  30
GLY A  32
HIS A  33
GLY A 144
ASP A 147
VAL A 173
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
AMP  A 280 (-3.9A)
0.96A 1qu2A-3uk2A:
2.5
1qu2A-3uk2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 HIS A  30
GLY A  32
HIS A  33
ASP A 147
VAL A 173
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
MLT  A 284 ( 3.5A)
AMP  A 280 (-3.9A)
0.98A 1qu3A-3uk2A:
3.8
1qu3A-3uk2A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 PRO A 106
PHE A 117
LEU A 113
ILE A 112
None
1.17A 1sbrA-3uk2A:
undetectable
1sbrB-3uk2A:
undetectable
1sbrA-3uk2A:
21.66
1sbrB-3uk2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 5 LEU A 132
VAL A 173
LEU A 181
ARG A  38
None
AMP  A 280 (-3.9A)
AMP  A 280 (-4.4A)
None
1.08A 2oiqA-3uk2A:
undetectable
2oiqA-3uk2A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.88A 2roxB-3uk2A:
undetectable
2roxB-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 11 HIS A  30
GLY A  32
HIS A  33
GLY A 144
ASP A 147
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
0.85A 2x1lA-3uk2A:
4.7
2x1lA-3uk2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 HIS A  30
GLY A  32
HIS A  33
GLY A 144
ASP A 147
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
0.79A 2x1lB-3uk2A:
undetectable
2x1lB-3uk2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 11 HIS A  30
GLY A  32
HIS A  33
GLY A 144
ASP A 147
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
0.82A 2x1lC-3uk2A:
undetectable
2x1lC-3uk2A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.91A 3cfqA-3uk2A:
undetectable
3cfqA-3uk2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 7 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.96A 3cfqA-3uk2A:
undetectable
3cfqB-3uk2A:
undetectable
3cfqA-3uk2A:
18.79
3cfqB-3uk2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 5 HIS A 227
SER A 229
ARG A 272
THR A 202
None
1.31A 3okxA-3uk2A:
undetectable
3okxA-3uk2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 5 HIS A 227
SER A 229
ARG A 272
THR A 202
None
1.27A 3okxB-3uk2A:
undetectable
3okxB-3uk2A:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
7 / 8 GLN A  57
ARG A 118
VAL A 125
VAL A 128
ASP A 147
GLN A 150
ARG A 184
EDO  A 285 ( 3.0A)
MLT  A 284 (-3.3A)
EDO  A 285 (-4.0A)
EDO  A 285 (-4.9A)
MLT  A 284 ( 3.5A)
MLT  A 284 ( 2.8A)
MLT  A 284 (-3.1A)
0.24A 3uy4A-3uk2A:
38.3
3uy4A-3uk2A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 8 GLN A  57
ARG A 118
VAL A 125
VAL A 129
ARG A 184
EDO  A 285 ( 3.0A)
MLT  A 284 (-3.3A)
EDO  A 285 (-4.0A)
None
MLT  A 284 (-3.1A)
1.40A 3uy4A-3uk2A:
38.3
3uy4A-3uk2A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.89A 4i89A-3uk2A:
undetectable
4i89A-3uk2A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.93A 4ikiB-3uk2A:
undetectable
4ikiB-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 7 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
1.00A 4ikjA-3uk2A:
undetectable
4ikjB-3uk2A:
undetectable
4ikjA-3uk2A:
18.44
4ikjB-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 7 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.93A 4ikkA-3uk2A:
undetectable
4ikkB-3uk2A:
undetectable
4ikkA-3uk2A:
18.44
4ikkB-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
3 / 3 SER A 183
TYR A  67
ASP A  74
None
0.80A 4rp8C-3uk2A:
undetectable
4rp8C-3uk2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 ASP A 258
LEU A 260
LEU A 217
ARG A 242
ILE A 254
None
1.01A 4x1fA-3uk2A:
undetectable
4x1fA-3uk2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 ASP A 258
LEU A 260
LEU A 217
ARG A 242
ILE A 254
None
1.00A 4x1gA-3uk2A:
undetectable
4x1gA-3uk2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.88A 5bojA-3uk2A:
undetectable
5bojA-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 5 LEU A 268
ALA A 266
LEU A 273
VAL A 238
None
0.98A 5cr1A-3uk2A:
undetectable
5cr1A-3uk2A:
18.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
11 / 12 HIS A  30
GLY A  32
LEU A  36
GLN A  57
TYR A  67
VAL A 128
GLY A 144
LYS A 146
ASP A 147
THR A 172
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.7A)
EDO  A 285 ( 3.0A)
None
EDO  A 285 (-4.9A)
AMP  A 280 (-3.3A)
None
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.2A)
AMP  A 280 (-4.4A)
0.44A 5hg0A-3uk2A:
33.1
5hg0A-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
5 / 12 HIS A  30
GLY A  32
VAL A 129
ASP A 147
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
None
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.4A)
1.10A 5hg0A-3uk2A:
33.1
5hg0A-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 12 HIS A  33
GLY A  32
GLN A  57
TYR A  67
GLY A 144
ASP A 147
AMP  A 280 (-4.0A)
AMP  A 280 ( 3.9A)
EDO  A 285 ( 3.0A)
None
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
1.40A 5hg0A-3uk2A:
33.1
5hg0A-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 12 HIS A  30
GLY A  32
HIS A  33
LEU A  36
TYR A  67
VAL A 125
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-4.7A)
None
EDO  A 285 (-4.0A)
1.10A 5hg0B-3uk2A:
33.0
5hg0B-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
10 / 12 HIS A  30
GLY A  32
HIS A  33
LEU A  36
TYR A  67
VAL A 128
GLY A 144
ASP A 147
THR A 172
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
AMP  A 280 (-4.7A)
None
EDO  A 285 (-4.9A)
AMP  A 280 (-3.3A)
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.2A)
AMP  A 280 (-4.4A)
0.28A 5hg0B-3uk2A:
33.0
5hg0B-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 12 HIS A  30
GLY A  32
HIS A  33
VAL A 129
ASP A 147
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.0A)
None
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.4A)
1.09A 5hg0B-3uk2A:
33.0
5hg0B-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
10 / 12 HIS A  30
GLY A  32
LEU A  36
TYR A  67
VAL A 128
GLY A 144
LYS A 146
ASP A 147
THR A 172
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
AMP  A 280 (-4.7A)
None
EDO  A 285 (-4.9A)
AMP  A 280 (-3.3A)
None
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.2A)
AMP  A 280 (-4.4A)
0.52A 5hg0B-3uk2A:
33.0
5hg0B-3uk2A:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
6 / 12 HIS A  30
GLY A  32
VAL A 129
LYS A 146
ASP A 147
LEU A 181
AMP  A 280 (-4.7A)
AMP  A 280 ( 3.9A)
None
None
MLT  A 284 ( 3.5A)
AMP  A 280 (-4.4A)
1.22A 5hg0B-3uk2A:
33.0
5hg0B-3uk2A:
35.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
4 / 6 LEU A 268
ALA A 266
LEU A 273
THR A 264
None
0.91A 5l4iA-3uk2A:
undetectable
5l4iA-3uk2A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis)
3 / 3 PHE A  58
ARG A 118
GLN A  57
None
MLT  A 284 (-3.3A)
EDO  A 285 ( 3.0A)
1.17A 6g1pB-3uk2A:
undetectable
6g1pB-3uk2A:
24.35