SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		5 / 12 GLY A  82
GLY A  77
GLN A  49
THR A 359
ILE A 370
 ADP  A1450 (-3.3A)
None
None
None
ADP  A1450 ( 4.0A)
 1.26A 2azxB-3uk6A:
undetectable		 2azxB-3uk6A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		5 / 11 GLY A  82
GLY A  77
GLN A  49
THR A 359
ILE A 370
 ADP  A1450 (-3.3A)
None
None
None
ADP  A1450 ( 4.0A)
 1.25A 2dr2A-3uk6A:
undetectable		 2dr2A-3uk6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		4 / 5 ILE A 332
SER A 342
PRO A 343
PRO A 347
 None
 1.29A 3bjwC-3uk6A:
undetectable		 3bjwC-3uk6A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		3 / 3 SER A 310
ASP A 349
ASP A 305
 None
 0.89A 3iv6A-3uk6A:
undetectable		 3iv6A-3uk6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		3 / 3 SER A 310
ASP A 349
ASP A 305
 None
 0.91A 3iv6C-3uk6A:
undetectable		 3iv6C-3uk6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		4 / 6 ILE A 103
GLY A 105
ILE A 346
LEU A 296
 None
 0.73A 4o8fB-3uk6A:
undetectable		 4o8fB-3uk6A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		4 / 5 GLY A 394
PRO A 361
THR A 367
THR A 397
 None
 1.27A 5h5fA-3uk6A:
undetectable		 5h5fA-3uk6A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3uk6 RUVB-LIKE 2
(Homo
sapiens) 		5 / 10 ILE A 346
ALA A 122
LEU A 312
LEU A 304
LEU A 324
 None
 0.96A 6f6nA-3uk6A:
undetectable
6f6nB-3uk6A:
undetectable		 6f6nA-3uk6A:
12.50
6f6nB-3uk6A:
11.80