SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.26A 1ekjA-3uk8A:
undetectable
1ekjB-3uk8A:
undetectable		 1ekjA-3uk8A:
24.40
1ekjB-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.98A 1ekjA-3uk8A:
undetectable
1ekjB-3uk8A:
undetectable		 1ekjA-3uk8A:
24.40
1ekjB-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.30A 1ekjA-3uk8A:
undetectable
1ekjB-3uk8A:
undetectable		 1ekjA-3uk8A:
24.40
1ekjB-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
VAL A 474
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
None
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 1.40A 1ekjA-3uk8A:
undetectable
1ekjB-3uk8A:
undetectable		 1ekjA-3uk8A:
24.40
1ekjB-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 7 CYH A 473
ASP A 475
HIS A 525
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
ACT  A 800 (-3.7A)
 0.26A 1ekjE-3uk8A:
undetectable
1ekjF-3uk8A:
undetectable		 1ekjE-3uk8A:
24.40
1ekjF-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 7 CYH A 473
ASP A 475
HIS A 525
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
ACT  A 800 (-3.7A)
 0.93A 1ekjE-3uk8A:
undetectable
1ekjF-3uk8A:
undetectable		 1ekjE-3uk8A:
24.40
1ekjF-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.30A 1ekjG-3uk8A:
undetectable
1ekjH-3uk8A:
undetectable		 1ekjG-3uk8A:
24.40
1ekjH-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 8 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.97A 1ekjG-3uk8A:
undetectable
1ekjH-3uk8A:
undetectable		 1ekjG-3uk8A:
24.40
1ekjH-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 6 CYH A 473
ASP A 475
HIS A 525
CYH A 535
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
 0.28A 1ekjG-3uk8A:
undetectable
1ekjH-3uk8A:
undetectable		 1ekjG-3uk8A:
24.40
1ekjH-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 6 CYH A 473
VAL A 474
HIS A 525
CYH A 535
 CD  A 700 ( 2.4A)
None
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
 1.39A 1ekjG-3uk8A:
undetectable
1ekjH-3uk8A:
undetectable		 1ekjG-3uk8A:
24.40
1ekjH-3uk8A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 7 GLY A 492
PRO A 490
HIS A 498
ALA A 623
 None
 0.95A 1gxsA-3uk8A:
undetectable
1gxsB-3uk8A:
undetectable		 1gxsA-3uk8A:
22.46
1gxsB-3uk8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.22A 1jhoA-3uk8A:
undetectable		 1jhoA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.23A 1jhrA-3uk8A:
undetectable		 1jhrA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.18A 1jhyA-3uk8A:
undetectable		 1jhyA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.21A 1l4nA-3uk8A:
undetectable		 1l4nA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.22A 1l5kA-3uk8A:
undetectable		 1l5kA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.23A 1l5lA-3uk8A:
undetectable		 1l5lA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.25A 1l5mA-3uk8A:
undetectable		 1l5mA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 GLY A 526
GLY A 534
GLY A 536
ASP A 475
HIS A 528
 None
None
ACT  A 800 (-3.7A)
ACT  A 800 ( 4.1A)
None
 1.10A 1wg8B-3uk8A:
undetectable		 1wg8B-3uk8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		3 / 3 LEU A 505
PHE A 556
ARG A 500
 None
 0.86A 1xdkF-3uk8A:
undetectable		 1xdkF-3uk8A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 GLY A 534
GLY A 526
ARG A 566
LYS A 472
LYS A 488
 None
 1.14A 1y4lA-3uk8A:
undetectable		 1y4lA-3uk8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 7 MET A   0
ARG A 446
LEU A 443
VAL A 605
 None
 1.30A 2hrcA-3uk8A:
undetectable		 2hrcA-3uk8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		4 / 7 PRO A 487
ILE A 470
PRO A 490
GLY A 492
 None
 0.97A 2y7kA-3uk8A:
undetectable		 2y7kA-3uk8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 ILE A 493
GLY A 492
VAL A 524
ALA A 495
VAL A 515
 None
 0.88A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 ILE A 493
GLY A 492
VAL A 524
ILE A 470
VAL A 515
 None
 0.86A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 10 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.38A 3ucjA-3uk8A:
undetectable		 3ucjA-3uk8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 10 CYH A 473
VAL A 474
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
None
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 1.21A 3ucjA-3uk8A:
undetectable		 3ucjA-3uk8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 10 CYH A 473
ASP A 475
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
ACT  A 800 ( 4.1A)
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 0.41A 3ucjB-3uk8A:
undetectable		 3ucjB-3uk8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 10 CYH A 473
VAL A 474
HIS A 525
CYH A 535
GLY A 536
 CD  A 700 ( 2.4A)
None
CD  A 700 (-3.5A)
CD  A 700 (-2.4A)
ACT  A 800 (-3.7A)
 1.22A 3ucjB-3uk8A:
undetectable		 3ucjB-3uk8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 VAL A 474
LEU A 594
ILE A 586
VAL A 640
LEU A 588
 None
 1.03A 3w68A-3uk8A:
undetectable		 3w68A-3uk8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 VAL A 474
LEU A 594
ILE A 586
VAL A 640
LEU A 588
 None
 1.02A 3w68D-3uk8A:
undetectable		 3w68D-3uk8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 9 THR A 512
GLY A 570
GLY A 561
LEU A 508
ARG A 566
 None
 1.27A 4kqiA-3uk8A:
undetectable		 4kqiA-3uk8A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		3 / 3 VAL A 617
LEU A 462
MET A 592
 None
 0.78A 5ikrA-3uk8A:
undetectable		 5ikrA-3uk8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE
(Conticribra
weissflogii) 		5 / 12 LEU A 471
GLY A 469
THR A 482
ILE A 493
VAL A 565
 None
 1.01A 6emuA-3uk8A:
undetectable		 6emuA-3uk8A:
27.56