SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 6 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 0.97A 1wmqA-3ukoA:
undetectable		 1wmqA-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 6 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 0.97A 1wmqB-3ukoA:
undetectable		 1wmqB-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 6 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 0.95A 1wpuA-3ukoA:
undetectable		 1wpuA-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 6 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 0.96A 1wpuB-3ukoA:
undetectable		 1wpuB-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 6 ILE A  74
GLY A  73
ALA A  72
HIS A  90
 None
 1.00A 1wrqA-3ukoA:
undetectable		 1wrqA-3ukoA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 PHE A 238
ALA A 209
ALA A 214
GLY A 204
TYR A 232
 None
None
None
NAD  A 402 (-3.3A)
None
 1.09A 2igtA-3ukoA:
7.1		 2igtA-3ukoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 PHE A 238
ALA A 209
ALA A 214
GLY A 204
TYR A 232
 None
None
None
NAD  A 402 (-3.3A)
None
 1.07A 2igtB-3ukoA:
6.6		 2igtB-3ukoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 GLY A 224
PHE A 269
SER A 268
ALA A 211
ASP A 226
 None
None
None
None
NAD  A 402 (-2.8A)
 1.18A 3id6C-3ukoA:
7.3		 3id6C-3ukoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 8 PHE A 325
GLY A 323
PHE A 322
ILE A 343
 None
 0.91A 3ko0O-3ukoA:
undetectable
3ko0Q-3ukoA:
undetectable		 3ko0O-3ukoA:
15.34
3ko0Q-3ukoA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 GLY A 224
PHE A 269
SER A 268
ALA A 211
ASP A 226
 None
None
None
None
NAD  A 402 (-2.8A)
 1.12A 3nmuA-3ukoA:
undetectable
3nmuF-3ukoA:
5.8		 3nmuA-3ukoA:
22.30
3nmuF-3ukoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 SER A 268
LEU A 183
VAL A 210
GLY A 213
ALA A 214
 None
 1.10A 4coxD-3ukoA:
undetectable		 4coxD-3ukoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 9 ALA A  12
ILE A 358
GLY A 356
THR A  44
ILE A  41
 None
 1.10A 4nptA-3ukoA:
undetectable		 4nptA-3ukoA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 5 LEU A 375
CYH A 373
CYH A 370
ASP A  50
 None
 1.47A 5mafA-3ukoA:
undetectable		 5mafA-3ukoA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 5 THR A 166
HIS A  90
ALA A 167
ASP A 164
 None
 1.35A 5mfxA-3ukoA:
2.7		 5mfxA-3ukoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 9 CYH A 271
GLY A 204
GLY A 207
ALA A 209
VAL A 210
 None
NAD  A 402 (-3.3A)
None
None
None
 0.99A 5v3cA-3ukoA:
3.8		 5v3cA-3ukoA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		3 / 3 ARG A 221
PHE A 243
LEU A 260
 None
 0.85A 5x1bC-3ukoA:
undetectable		 5x1bC-3ukoA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		4 / 5 ILE A 253
PHE A 201
ARG A 315
THR A 306
 None
 1.27A 5z84N-3ukoA:
undetectable
5z84W-3ukoA:
undetectable		 5z84N-3ukoA:
20.92
5z84W-3ukoA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 3uko ALCOHOL
DEHYDROGENASE
CLASS-3
(Arabidopsis
thaliana) 		5 / 12 GLY A 207
VAL A 186
ILE A 253
ALA A 281
ALA A 280
 None
 1.06A 6c2mD-3ukoA:
undetectable		 6c2mD-3ukoA:
11.32