SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ul4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 VAL A  15
GLY A  13
ILE A  11
SER A  28
THR A 103
 None
 0.80A 3bjwB-3ul4A:
undetectable		 3bjwB-3ul4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 VAL A  15
GLY A  13
ILE A  11
SER A  28
THR A 103
 None
 0.84A 3bjwF-3ul4A:
undetectable		 3bjwF-3ul4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 VAL A  15
GLY A  13
ILE A  11
SER A  28
THR A 103
 None
 0.85A 3bjwH-3ul4A:
undetectable		 3bjwH-3ul4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ALA A  81
LEU A  83
SER A  70
VAL A  74
 None
None
None
SO4  A 158 (-4.0A)
 0.58A 3d2tB-3ul4A:
undetectable		 3d2tB-3ul4A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A  71
VAL A  27
THR A 103
PHE A  69
 None
 1.07A 3ltwA-3ul4A:
undetectable		 3ltwA-3ul4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
CELLULOSOME ENZYME,
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		3 / 3 THR B  50
ASN B  42
GLU A 134
 None
CA  B  66 (-3.0A)
None
 0.72A 3v4tA-3ul4B:
undetectable
3v4tC-3ul4B:
undetectable		 3v4tA-3ul4B:
8.41
3v4tC-3ul4B:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
CELLULOSOME ENZYME,
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		4 / 7 LEU B  26
ASP A  41
SER B  49
TYR B  19
 None
 1.32A 4arcA-3ul4B:
undetectable		 4arcA-3ul4B:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
CELLULOSOME ENZYME,
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum;
Ruminiclostridiu
m
thermocellum) 		5 / 12 PRO A 137
TYR A  84
ASP B  51
THR B  50
ASN B  42
 None
None
CA  B  66 (-2.2A)
None
CA  B  66 (-3.0A)
 1.42A 4xe0A-3ul4A:
undetectable		 4xe0A-3ul4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3ul4 CELLULOSOME ENZYME,
DOCKERIN TYPE I
CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 LEU B  26
ALA A  81
LEU A  83
VAL A  74
 None
None
None
SO4  A 158 (-4.0A)
 1.05A 5cr1A-3ul4B:
undetectable		 5cr1A-3ul4B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3ul4 CELLULOSOME ENZYME,
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASN B   5
ASP B  44
GLY B  45
 None
CA  B  66 (-2.9A)
None
 0.43A 5fctB-3ul4B:
undetectable		 5fctB-3ul4B:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ul4 CELLULOSOME-ANCHORIN
G PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 127
ILE A  37
PHE A  69
PHE A 101
LEU A  56
 None
 1.44A 6a93A-3ul4A:
undetectable		 6a93A-3ul4A:
15.58