SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ulz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
ALA A 315
GLU A 334
LEU A 361
MET A 366
GLY A 369
LEU A 423
None
0.84A 1m17A-3ulzA:
24.4
1m17A-3ulzA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
GLU A 334
LEU A 361
MET A 366
GLY A 369
LEU A 423
ASP A 434
None
0.91A 1m17A-3ulzA:
24.4
1m17A-3ulzA:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 9 LEU A 295
GLY A 296
VAL A 303
ALA A 315
LEU A 347
TYR A 365
LEU A 423
None
0.98A 1muoA-3ulzA:
18.8
1muoA-3ulzA:
28.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
4 / 8 LEU A 423
GLY A 433
MET A 481
GLU A 484
None
0.85A 1n13A-3ulzA:
undetectable
1n13F-3ulzA:
undetectable
1n13A-3ulzA:
10.67
1n13F-3ulzA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
4 / 7 LEU A 423
GLY A 433
MET A 481
GLU A 484
None
0.85A 1n13G-3ulzA:
undetectable
1n13J-3ulzA:
undetectable
1n13G-3ulzA:
10.67
1n13J-3ulzA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
None
1.02A 1uwhA-3ulzA:
22.7
1uwhA-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 303
ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
None
1.14A 1uwjA-3ulzA:
6.3
1uwjA-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 303
ALA A 315
GLU A 334
LEU A 347
LEU A 404
HIS A 414
GLY A 433
None
1.13A 1uwjB-3ulzA:
6.2
1uwjB-3ulzA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 9 LEU A 295
VAL A 303
ALA A 315
GLY A 369
LEU A 423
None
0.48A 1xbbA-3ulzA:
26.5
1xbbA-3ulzA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 9 LEU A 295
LYS A 317
LEU A 349
LEU A 361
MET A 366
None
0.69A 1xkkA-3ulzA:
22.3
1xkkA-3ulzA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 GLY A 567
GLU A 570
ASP A 566
None
0.64A 2b25B-3ulzA:
undetectable
2b25B-3ulzA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 11 GLY A 296
VAL A 303
ALA A 315
TYR A 365
SER A 370
LEU A 423
ASP A 434
None
0.86A 2evaA-3ulzA:
23.1
2evaA-3ulzA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
ASP A 416
ALA A 420
ASN A 421
None
1.06A 2fumA-3ulzA:
2.1
2fumA-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
GLY A 296
VAL A 303
ASP A 416
ALA A 420
ASN A 421
ASP A 434
None
0.96A 2fumA-3ulzA:
2.1
2fumA-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
LYS A 418
ASN A 421
None
None
None
None
None
TPO  A 455 ( 2.9A)
None
0.98A 2fumB-3ulzA:
22.0
2fumB-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
ASN A 421
ASP A 434
None
0.96A 2fumC-3ulzA:
20.3
2fumC-3ulzA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 ASP A 416
VAL A 417
HIS A 414
ALA A 394
VAL A 432
None
1.45A 2g70B-3ulzA:
undetectable
2g70B-3ulzA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 ARG A 344
ARG A 392
ARG A 399
None
1.12A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable
2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 ARG A 392
ARG A 399
ARG A 344
None
1.12A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable
2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 ARG A 399
ARG A 344
ARG A 392
None
1.11A 2jb7A-3ulzA:
undetectable
2jb7B-3ulzA:
undetectable
2jb7C-3ulzA:
undetectable
2jb7A-3ulzA:
18.07
2jb7B-3ulzA:
18.07
2jb7C-3ulzA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 11 SER A 397
LEU A 385
ILE A 422
GLU A 564
LEU A 538
None
1.44A 2v0mA-3ulzA:
undetectable
2v0mA-3ulzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 542
LEU A 538
GLN A 489
LEU A 375
THR A 546
None
1.17A 2w3mB-3ulzA:
undetectable
2w3mB-3ulzA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 GLY A 296
VAL A 303
ALA A 315
LEU A 347
TYR A 365
MET A 366
GLY A 369
None
0.72A 2wgjA-3ulzA:
23.0
2wgjA-3ulzA:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 9 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.50A 2xp2A-3ulzA:
5.7
2xp2A-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 303
ALA A 315
LEU A 349
GLY A 369
LEU A 423
ASP A 434
None
0.69A 3bbtB-3ulzA:
22.0
3bbtB-3ulzA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 10 LEU A 295
VAL A 303
ALA A 315
TYR A 365
GLY A 369
LEU A 423
None
0.80A 3g0fB-3ulzA:
21.9
3g0fB-3ulzA:
24.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
ALA A 315
GLU A 334
ILE A 338
GLY A 369
LEU A 423
None
1.48A 3ms9B-3ulzA:
22.4
3ms9B-3ulzA:
31.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 VAL A 541
LEU A 401
LEU A 563
GLY A 477
LEU A 482
None
0.96A 3n8wA-3ulzA:
undetectable
3n8wA-3ulzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 VAL A 541
LEU A 401
LEU A 563
GLY A 477
LEU A 482
None
1.01A 3n8zA-3ulzA:
undetectable
3n8zA-3ulzA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 LEU A 401
LEU A 563
VAL A 475
GLY A 477
LEU A 482
None
1.04A 3pghD-3ulzA:
undetectable
3pghD-3ulzA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
VAL A 303
ALA A 315
GLU A 334
TYR A 365
GLY A 369
LEU A 423
ASP A 434
None
1.05A 3qlgB-3ulzA:
23.3
3qlgB-3ulzA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
ALA A 315
LEU A 361
MET A 366
GLY A 369
LEU A 423
None
0.68A 3ug2A-3ulzA:
24.0
3ug2A-3ulzA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
ALA A 315
LEU A 347
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.71A 3zbfA-3ulzA:
23.4
3zbfA-3ulzA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 9 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
None
0.51A 4anqA-3ulzA:
22.2
4anqA-3ulzA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 9 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
None
0.53A 4ansA-3ulzA:
22.1
4ansA-3ulzA:
27.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 11 LEU A 295
GLY A 296
GLY A 298
VAL A 303
ALA A 315
TYR A 365
GLY A 369
LEU A 423
None
1.14A 4ckiA-3ulzA:
26.4
4ckiA-3ulzA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 11 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
GLY A 369
SER A 370
LEU A 423
None
0.74A 4ckiA-3ulzA:
26.4
4ckiA-3ulzA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 10 LEU A 295
GLY A 296
VAL A 303
ALA A 315
TYR A 365
SER A 370
LEU A 423
None
0.76A 4ckjA-3ulzA:
26.3
4ckjA-3ulzA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
VAL A 303
ALA A 315
LYS A 317
MET A 366
GLY A 369
LEU A 423
ASP A 434
None
0.82A 4hjoA-3ulzA:
17.7
4hjoA-3ulzA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
LEU A 361
GLY A 369
LEU A 423
ASP A 434
None
0.78A 4i22A-3ulzA:
21.6
4i22A-3ulzA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 TYR A 463
ARG A 415
SER A 469
None
TPO  A 450 ( 3.3A)
TPO  A 450 ( 4.0A)
0.61A 4khpI-3ulzA:
undetectable
4khpJ-3ulzA:
undetectable
4khpI-3ulzA:
20.75
4khpJ-3ulzA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXX_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
VAL A 303
ALA A 315
LYS A 317
TYR A 365
MET A 366
GLY A 369
LEU A 423
None
0.83A 4mxxB-3ulzA:
21.9
4mxxB-3ulzA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 6 VAL A 303
ALA A 315
LYS A 317
LEU A 347
LEU A 423
None
0.84A 4o0uA-3ulzA:
19.3
4o0uA-3ulzA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
LYS A 317
TYR A 365
GLY A 369
LEU A 423
ASP A 434
None
0.89A 4otwA-3ulzA:
21.6
4otwA-3ulzA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 9 LEU A 295
VAL A 303
ALA A 315
TYR A 365
MET A 366
GLY A 369
LEU A 423
None
0.69A 4u5jB-3ulzA:
23.8
4u5jB-3ulzA:
28.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WA9_A_AXIA9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 11 LEU A 295
ALA A 315
MET A 366
GLY A 369
ASN A 421
LEU A 423
None
0.87A 4wa9A-3ulzA:
21.6
4wa9A-3ulzA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 ASP A 523
ARG A 378
PRO A 384
None
0.95A 4wanC-3ulzA:
undetectable
4wanC-3ulzA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
4 / 6 LEU A 295
ALA A 315
MET A 366
LEU A 423
None
0.50A 4wboC-3ulzA:
20.3
4wboC-3ulzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 11 ALA A 285
GLY A 311
VAL A 316
LEU A 349
LEU A 360
None
TPO  A 312 ( 2.5A)
None
None
None
1.09A 4zmeA-3ulzA:
4.8
4zmeA-3ulzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 9 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.54A 5aaaA-3ulzA:
22.6
5aaaA-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 10 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.55A 5aabA-3ulzA:
22.4
5aabA-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 10 LEU A 295
VAL A 303
ALA A 315
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.54A 5aacA-3ulzA:
22.2
5aacA-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 10 LEU A 295
VAL A 303
LYS A 317
MET A 366
GLY A 369
LEU A 423
GLY A 433
None
0.72A 5aacA-3ulzA:
22.2
5aacA-3ulzA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
None
0.53A 5h2uA-3ulzA:
23.2
5h2uA-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
ALA A 315
LYS A 317
LEU A 347
GLY A 369
GLY A 433
None
0.76A 5h2uA-3ulzA:
23.2
5h2uA-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
VAL A 303
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
None
0.59A 5h2uB-3ulzA:
18.5
5h2uB-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
VAL A 303
ALA A 315
LYS A 317
LEU A 347
GLY A 433
ASP A 434
None
0.85A 5h2uB-3ulzA:
18.5
5h2uB-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_C_1N1C501_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 LEU A 295
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
None
0.51A 5h2uC-3ulzA:
18.5
5h2uC-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
VAL A 303
ALA A 315
LEU A 347
GLY A 369
LEU A 423
GLY A 433
ASP A 434
None
0.60A 5h2uD-3ulzA:
23.1
5h2uD-3ulzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
5 / 12 LEU A 401
LEU A 563
VAL A 475
GLY A 477
LEU A 482
None
1.05A 5ikrB-3ulzA:
undetectable
5ikrB-3ulzA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
3 / 3 LYS A 291
GLN A 283
ASN A 288
SEP  A 290 ( 3.0A)
None
None
0.90A 5l2tA-3ulzA:
4.4
5l2tA-3ulzA:
28.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 12 LEU A 295
ALA A 315
GLU A 334
LEU A 361
GLY A 369
GLY A 433
None
0.97A 5vcvA-3ulzA:
22.4
5vcvA-3ulzA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
8 / 12 LEU A 295
GLY A 296
VAL A 303
ALA A 315
LYS A 317
LEU A 361
LEU A 423
ASP A 434
None
0.93A 5yu9A-3ulzA:
21.5
5yu9A-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
7 / 12 GLY A 296
VAL A 303
ALA A 315
LYS A 317
LEU A 361
LEU A 423
ASP A 434
None
0.94A 5yu9B-3ulzA:
21.5
5yu9B-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 303
ALA A 315
LYS A 317
LEU A 361
GLY A 369
ASP A 434
None
1.03A 5yu9C-3ulzA:
21.2
5yu9C-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 303
ALA A 315
LYS A 317
GLY A 369
LEU A 423
ASP A 434
None
1.01A 5yu9D-3ulzA:
16.8
5yu9D-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana)
4 / 5 LEU A 295
ILE A 338
MET A 366
GLY A 369
None
1.07A 6hd6A-3ulzA:
22.4
6hd6A-3ulzA:
14.58