SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3um1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA206_1
(CARDIAC TROPONIN C)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		4 / 8 GLN A  69
PRO A 359
GLU A 110
ARG A  85
 None
 1.10A 1dtlA-3um1A:
undetectable		 1dtlA-3um1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		4 / 8 PHE A 373
TRP A 365
ASP A  35
THR A  25
 None
 1.10A 1rmtD-3um1A:
undetectable		 1rmtD-3um1A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 11 LEU A 175
THR A  95
LYS A  11
LEU A 120
PHE A 154
 None
 1.24A 1tw4A-3um1A:
undetectable		 1tw4A-3um1A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 12 ILE A 271
GLY A 258
VAL A 316
PHE A 332
ALA A 277
 None
 1.32A 1vq1A-3um1A:
undetectable		 1vq1A-3um1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		4 / 5 PHE A 358
PHE A  65
LEU A  43
PHE A  47
 None
 1.37A 3abmC-3um1A:
2.7
3abmJ-3um1A:
undetectable		 3abmC-3um1A:
20.59
3abmJ-3um1A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 11 LEU A 274
TYR A 252
TYR A 281
PHE A 309
LEU A 312
 None
 1.41A 3bgrA-3um1A:
0.8
3bgrB-3um1A:
0.7		 3bgrA-3um1A:
21.31
3bgrB-3um1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 11 TYR A 252
TYR A 281
PHE A 309
LEU A 312
GLU A 276
 None
None
None
None
GOL  A   1 (-3.3A)
 1.36A 3bgrA-3um1A:
0.8
3bgrB-3um1A:
0.7		 3bgrA-3um1A:
21.31
3bgrB-3um1A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 12 CYH A 187
ARG A 145
VAL A 184
ALA A 119
TYR A 122
 None
 1.15A 3qxvE-3um1A:
undetectable		 3qxvE-3um1A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 11 THR A 369
THR A  25
GLY A  26
PRO A  27
ASP A 374
 None
 1.32A 3t8nD-3um1A:
undetectable
3t8nF-3um1A:
undetectable		 3t8nD-3um1A:
16.37
3t8nF-3um1A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		4 / 4 LEU A 274
GLY A 258
LEU A 262
GLU A 259
 None
 1.02A 3tgvB-3um1A:
undetectable		 3tgvB-3um1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1105_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		5 / 11 PHE A  47
THR A  93
GLY A  98
ARG A 128
GLN A  99
 None
 1.37A 4dx7A-3um1A:
0.0		 4dx7A-3um1A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		3 / 3 CYH A  52
MET A  57
ASN A  59
 None
 1.38A 5qh8A-3um1A:
undetectable		 5qh8A-3um1A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		3 / 3 GLU A 231
LEU A 230
ARG A 178
 None
 0.78A 6d8fA-3um1A:
undetectable		 6d8fA-3um1A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		3 / 3 ARG A 145
LYS A  58
TYR A 122
 None
 1.14A 6gnaA-3um1A:
undetectable		 6gnaA-3um1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		3 / 3 ARG A 145
LYS A  58
TYR A 122
 None
 1.14A 6gnbA-3um1A:
undetectable		 6gnbA-3um1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX
(Homo
sapiens) 		3 / 3 THR A 361
GLU A  77
ASN A  73
 None
 0.85A 6nj9K-3um1A:
undetectable		 6nj9K-3um1A:
22.22