SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3um9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		6 / 12 ILE A 125
LEU A 104
PRO A 101
VAL A 100
LEU A  15
ILE A 116
 None
 1.46A 1df7A-3um9A:
undetectable		 1df7A-3um9A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 12 PHE A 173
THR A  14
ILE A 194
VAL A 206
ALA A 184
 None
 1.30A 1vq1A-3um9A:
2.7		 1vq1A-3um9A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 194
LEU A 107
LEU A 104
VAL A 100
LEU A  15
 None
 1.23A 2bxfA-3um9A:
undetectable		 2bxfA-3um9A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 12 LEU A  75
LEU A  79
GLY A  83
HIS A  86
LEU A  87
 None
 1.08A 2ouzA-3um9A:
undetectable		 2ouzA-3um9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 12 ASP A 145
GLY A 120
GLN A  44
ARG A  41
ILE A 125
 None
None
None
SO4  A 231 ( 4.5A)
None
 1.45A 4djeA-3um9A:
undetectable		 4djeA-3um9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 12 ALA A  67
LEU A  68
THR A  71
VAL A  21
LEU A  87
 None
 1.12A 4g1bA-3um9A:
4.1		 4g1bA-3um9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JDC_D_6JPD302_1
(PTERIDINE REDUCTASE)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 11 ASP A 180
TYR A 157
VAL A 174
LEU A 172
PRO A 190
 SO4  A 231 ( 4.8A)
None
None
None
None
 1.47A 5jdcA-3um9A:
5.9
5jdcD-3um9A:
5.5		 5jdcA-3um9A:
19.73
5jdcD-3um9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		4 / 7 PHE A 173
GLY A  13
TYR A  12
TYR A  16
 None
None
SO4  A 231 (-4.3A)
None
 1.06A 5uxdA-3um9A:
undetectable		 5uxdA-3um9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3um9 HALOACID
DEHALOGENASE, TYPE
II
(Polaromonas
sp.
JS666) 		5 / 10 PHE A 222
GLY A 111
ARG A 108
LEU A 107
PHE A 201
 None
 1.11A 5zjiA-3um9A:
undetectable
5zjiJ-3um9A:
undetectable		 5zjiA-3um9A:
13.51
5zjiJ-3um9A:
11.50