SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3umb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 10 ALA A  11
ASP A  10
ARG A  49
TYR A  95
THR A  14
 None
 1.40A 1tdrB-3umbA:
undetectable		 1tdrB-3umbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 12 ILE A 175
LEU A 176
ALA A 164
GLY A 119
LEU A 108
 None
 1.13A 2a58A-3umbA:
2.7
2a58B-3umbA:
2.8		 2a58A-3umbA:
21.85
2a58B-3umbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 12 ILE A 175
LEU A 176
ALA A 164
GLY A 119
LEU A 108
 None
 1.12A 2a58B-3umbA:
2.8
2a58C-3umbA:
2.8		 2a58B-3umbA:
21.85
2a58C-3umbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 12 ILE A 175
LEU A 176
ALA A 164
GLY A 119
LEU A 108
 None
 1.13A 2a58D-3umbA:
2.8
2a58E-3umbA:
2.8		 2a58D-3umbA:
21.85
2a58E-3umbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 5 ILE A 175
PRO A 117
VAL A  18
PHE A 142
 None
 1.09A 2ygnA-3umbA:
undetectable		 2ygnA-3umbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 8 GLY A 137
VAL A  18
SER A 139
TYR A  12
 None
 0.89A 2yoeB-3umbA:
undetectable
2yoeC-3umbA:
undetectable		 2yoeB-3umbA:
23.25
2yoeC-3umbA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 9 THR A 194
LEU A 176
ALA A 213
GLN A 224
PHE A 225
 None
 1.40A 4ltwA-3umbA:
undetectable		 4ltwA-3umbA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 6 LEU A  79
ASP A  42
VAL A  21
ALA A  22
 None
MG  A 240 (-2.8A)
None
None
 0.87A 4nkxA-3umbA:
undetectable		 4nkxA-3umbA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 12 MET A 219
LEU A 141
ILE A 120
ALA A 100
LEU A  15
 None
 1.30A 5ienA-3umbA:
undetectable		 5ienA-3umbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 12 GLU A 206
GLY A 182
ILE A 198
ALA A 215
ALA A 185
 None
 1.00A 5kvaA-3umbA:
undetectable		 5kvaA-3umbA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		5 / 10 VAL A 145
ILE A 120
LEU A  15
PHE A   9
GLY A 140
 None
 0.85A 5mxbA-3umbA:
undetectable		 5mxbA-3umbA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		3 / 3 ASP A  10
PHE A  64
ARG A  41
 None
 1.05A 5yw0A-3umbA:
undetectable		 5yw0A-3umbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 8 TRP A 190
THR A 189
TYR A 161
LEU A 208
 None
 1.37A 6cnjD-3umbA:
undetectable
6cnjE-3umbA:
undetectable		 6cnjD-3umbA:
14.29
6cnjE-3umbA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 5 SER A 147
VAL A 148
ASN A 123
PRO A  63
 None
 1.41A 6fi4A-3umbA:
undetectable
6fi4B-3umbA:
undetectable		 6fi4A-3umbA:
24.05
6fi4B-3umbA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3umb DEHALOGENASE-LIKE
HYDROLASE
(Ralstonia
solanacearum) 		4 / 8 ASP A 149
SER A 147
TYR A  61
ASN A 123
 None
 1.12A 6giqL-3umbA:
undetectable
6giqP-3umbA:
undetectable
6giqT-3umbA:
undetectable		 6giqL-3umbA:
21.48
6giqP-3umbA:
22.41
6giqT-3umbA:
13.84