SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3umc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  86
ASP A  84
GLU A  29
LEU A  34
ILE A  91
 None
 1.13A 1d1gA-3umcA:
undetectable		 1d1gA-3umcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  86
ASP A  84
GLU A  29
LEU A  34
ILE A  91
 None
 1.17A 1d1gB-3umcA:
undetectable		 1d1gB-3umcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  75
SER A  71
HIS A  63
HIS A  96
ILE A  91
 None
 1.42A 1fmjA-3umcA:
0.0		 1fmjA-3umcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  75
SER A  71
HIS A  63
HIS A  96
ILE A  91
 None
 1.38A 1fmjB-3umcA:
0.0		 1fmjB-3umcA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  34
PHE A  23
LEU A  81
LEU A  83
ILE A  91
 None
 1.15A 2bxeB-3umcA:
undetectable		 2bxeB-3umcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  34
PHE A  23
LEU A  87
ILE A  91
ALA A  76
 None
 1.04A 2bxeB-3umcA:
undetectable		 2bxeB-3umcA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A   8
SER A 121
LEU A  98
HIS A  96
 CL  A 234 (-4.0A)
CL  A 234 (-2.5A)
None
None
 1.34A 2f8dA-3umcA:
undetectable		 2f8dA-3umcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  80
ILE A  91
LEU A  88
LEU A  30
LEU A  34
 None
 1.11A 3cs8A-3umcA:
undetectable		 3cs8A-3umcA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A  70
LEU A  72
GLU A  73
LEU A  88
 None
 0.81A 3h5gA-3umcA:
undetectable
3h5gC-3umcA:
undetectable		 3h5gA-3umcA:
8.93
3h5gC-3umcA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 225
LEU A 117
PHE A  -2
LEU A 190
ALA A 161
 None
 1.14A 3vw7A-3umcA:
undetectable		 3vw7A-3umcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A   7
ALA A 145
TYR A 151
ASP A 181
 CL  A 234 (-4.0A)
None
None
None
 1.21A 4mdaA-3umcA:
undetectable		 4mdaA-3umcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASP A   7
ALA A 145
TYR A 151
ASP A 181
 CL  A 234 (-4.0A)
None
None
None
 1.18A 4mdbA-3umcA:
undetectable		 4mdbA-3umcA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 10 SER A  18
SER A  17
LEU A 137
LEU A  12
LEU A 222
 None
 1.16A 4yiaA-3umcA:
undetectable		 4yiaA-3umcA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		4 / 6 HIS A  68
LEU A 127
HIS A  96
LEU A  98
 None
 1.32A 5hrqD-3umcA:
undetectable
5hrqG-3umcA:
undetectable
5hrqH-3umcA:
undetectable		 5hrqD-3umcA:
9.23
5hrqG-3umcA:
6.93
5hrqH-3umcA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3umc HALOACID
DEHALOGENASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A   9
GLY A  10
HIS A  68
LEU A  64
TYR A  47
 CL  A 234 (-4.4A)
None
None
None
None
 1.37A 5ji0D-3umcA:
undetectable		 5ji0D-3umcA:
24.41