SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3umg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		4 / 8 VAL A  51
PRO A 220
HIS A 221
ASP A  49
 None
 1.06A 2ddwA-3umgA:
2.1		 2ddwA-3umgA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		3 / 3 PRO A   5
ASN A  14
ARG A   7
 None
 0.83A 2qeuB-3umgA:
undetectable		 2qeuB-3umgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 11 ILE A 134
ALA A  17
LEU A 246
ILE A 128
PHE A  20
 None
 1.09A 2w9sB-3umgA:
undetectable		 2w9sB-3umgA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 10 ILE A 134
ALA A  17
LEU A 246
ILE A 128
PHE A  20
 None
 1.11A 2w9sF-3umgA:
undetectable		 2w9sF-3umgA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		4 / 7 ASP A  21
SER A 138
LYS A 169
ASP A  66
 CL  A 255 (-3.7A)
CL  A 255 (-2.9A)
CL  A 255 ( 3.9A)
None
 1.19A 3bc9A-3umgA:
undetectable		 3bc9A-3umgA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 VAL A  26
ALA A 193
PHE A  20
LEU A 246
ILE A 239
 None
 1.18A 3qfxA-3umgA:
undetectable		 3qfxA-3umgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 VAL A  26
ALA A 194
PHE A  20
LEU A 246
ILE A 239
 None
 1.18A 3qfxA-3umgA:
undetectable		 3qfxA-3umgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 VAL A  26
ALA A 193
PHE A  20
LEU A 246
ILE A 239
 None
 1.17A 3qfxB-3umgA:
undetectable		 3qfxB-3umgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 VAL A  26
ALA A 194
PHE A  20
LEU A 246
ILE A 239
 None
 1.20A 3qfxB-3umgA:
undetectable		 3qfxB-3umgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 LEU A 242
LEU A 246
ALA A 192
LEU A  19
LEU A 184
 None
 1.09A 3r9cA-3umgA:
0.9		 3r9cA-3umgA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		4 / 8 ALA A 236
ILE A 212
ALA A 243
ALA A 244
 None
 0.75A 3r9tA-3umgA:
undetectable		 3r9tA-3umgA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 LEU A  86
HIS A 100
LEU A 108
ASP A 106
PRO A  97
 None
 0.89A 4blvA-3umgA:
undetectable		 4blvA-3umgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 11 ASP A 198
PRO A 186
VAL A 189
GLY A 206
THR A 178
 None
 1.27A 4mmaA-3umgA:
undetectable		 4mmaA-3umgA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 ASP A 163
GLY A 161
THR A  77
LEU A 137
TRP A 156
 None
 1.29A 4pghB-3umgA:
2.1		 4pghB-3umgA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		3 / 3 GLU A 188
ARG A  13
GLN A 180
 None
 0.96A 4rtbA-3umgA:
undetectable		 4rtbA-3umgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		3 / 3 ASN A  85
SER A  64
ARG A  73
 None
 0.94A 5b2qA-3umgA:
undetectable		 5b2qA-3umgA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		4 / 6 HIS A  82
LEU A 144
HIS A 113
LEU A 115
 None
 1.35A 5hrqD-3umgA:
undetectable
5hrqG-3umgA:
undetectable
5hrqH-3umgA:
undetectable		 5hrqD-3umgA:
10.24
5hrqG-3umgA:
10.34
5hrqH-3umgA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3umg HALOACID
DEHALOGENASE
(Rhodococcus
jostii) 		5 / 12 PHE A  23
GLY A  24
LEU A 125
ILE A 212
LEU A 144
 CL  A 255 ( 4.8A)
None
None
None
None
 1.12A 5y2tA-3umgA:
undetectable		 5y2tA-3umgA:
undetectable