SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3umt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 7 GLN A 175
ILE A 181
TYR A 224
PHE A 235
 None
 1.12A 1e71M-3umtA:
undetectable		 1e71M-3umtA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 7 GLN A 175
ILE A 181
TYR A 224
PHE A 235
 None
 1.15A 1e72M-3umtA:
undetectable		 1e72M-3umtA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 6 GLN A 175
ILE A 181
TYR A 224
PHE A 235
 None
 1.12A 1e73M-3umtA:
undetectable		 1e73M-3umtA:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 6 TRP A 111
ASN A 171
LEU A 173
PHE A 235
 None
 0.68A 1ru9H-3umtA:
19.7
1ru9L-3umtA:
20.4		 1ru9H-3umtA:
31.82
1ru9L-3umtA:
25.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 6 TRP A 111
ASN A 171
LEU A 173
PHE A 235
 None
 0.72A 1rukH-3umtA:
19.4
1rukL-3umtA:
20.4		 1rukH-3umtA:
31.82
1rukL-3umtA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 8 ILE A  50
SER A  61
GLY A  51
SER A 231
 None
NHE  A 300 (-4.6A)
None
NHE  A 300 ( 4.4A)
 0.91A 3lslA-3umtA:
undetectable
3lslD-3umtA:
undetectable		 3lslA-3umtA:
21.03
3lslD-3umtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 8 SER A 231
ILE A  50
SER A  61
GLY A  51
 NHE  A 300 ( 4.4A)
None
NHE  A 300 (-4.6A)
None
 0.85A 3lslA-3umtA:
undetectable
3lslD-3umtA:
undetectable		 3lslA-3umtA:
21.03
3lslD-3umtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		4 / 4 LEU A 152
GLY A 153
LEU A 215
GLU A 216
 None
 1.04A 3tgvB-3umtA:
undetectable		 3tgvB-3umtA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		5 / 12 HIS A  37
SER A  61
PHE A 108
GLN A 227
PRO A 233
 None
NHE  A 300 (-4.6A)
None
None
NHE  A 300 ( 4.6A)
 0.65A 4uilH-3umtA:
21.3
4uilL-3umtA:
19.5		 4uilH-3umtA:
42.97
4uilL-3umtA:
39.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		5 / 11 ASN A 171
LEU A 173
ARG A 183
HIS A  37
TRP A 111
 None
 0.82A 5cp3A-3umtA:
20.7
5cp3H-3umtA:
18.8		 5cp3A-3umtA:
24.52
5cp3H-3umtA:
33.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP3_A_YTZA301_1
(LIGHT CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7
HEAVY CHAIN OF
ANTIGEN-BINDING
FRAGMENT OF
MONOCLONAL ANTIBODY
OF 4C7)		 3umt SCFV HEAVY CHAIN AND
LIGHT CHAIN
(Mus
musculus) 		5 / 11 ASN A 171
LEU A 173
HIS A  37
ALA A  99
TRP A 111
 None
 0.82A 5cp3A-3umtA:
20.7
5cp3H-3umtA:
18.8		 5cp3A-3umtA:
24.52
5cp3H-3umtA:
33.47