SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3un6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 10 LEU A  93
LEU A  96
ALA A  97
LEU A  78
HIS A 114
 None
None
None
None
ZN  A 325 ( 4.9A)
 1.09A 1gwrA-3un6A:
undetectable		 1gwrA-3un6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		3 / 3 PHE A 304
TYR A 291
PRO A 306
 None
 1.05A 1mcnA-3un6A:
undetectable
1mcnB-3un6A:
undetectable
1mcnP-3un6A:
undetectable		 1mcnA-3un6A:
20.46
1mcnB-3un6A:
20.46
1mcnP-3un6A:
2.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 6 PRO A 143
HIS A 149
ILE A  44
SER A  91
 ZN  A 326 ( 4.7A)
ZN  A 326 ( 4.6A)
ZN  A 326 ( 4.5A)
None
 1.18A 1sbrA-3un6A:
undetectable
1sbrB-3un6A:
undetectable		 1sbrA-3un6A:
21.31
1sbrB-3un6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 7 TYR A 281
GLY A 117
THR A 279
ASN A 118
 None
None
None
ZN  A 325 ( 4.7A)
 0.97A 2g70A-3un6A:
undetectable		 2g70A-3un6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 7 TYR A 281
GLY A 117
THR A 279
ASN A 118
 None
None
None
ZN  A 325 ( 4.7A)
 0.98A 2g70B-3un6A:
undetectable		 2g70B-3un6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 LEU A  93
LEU A  96
ALA A  97
LEU A  78
HIS A 114
 None
None
None
None
ZN  A 325 ( 4.9A)
 1.10A 3olsA-3un6A:
undetectable		 3olsA-3un6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 9 ALA A  81
GLY A  85
ASP A  88
ASN A 106
ILE A 107
 None
 1.26A 3wdmA-3un6A:
undetectable		 3wdmA-3un6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 8 HIS A 264
ASP A 243
TYR A 244
HIS A 263
 None
 1.08A 3x2qA-3un6A:
undetectable
3x2qC-3un6A:
undetectable
3x2qP-3un6A:
undetectable		 3x2qA-3un6A:
23.14
3x2qC-3un6A:
20.86
3x2qP-3un6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		3 / 3 LYS A 101
PRO A 307
LYS A 108
 None
 1.19A 4dv7L-3un6A:
undetectable		 4dv7L-3un6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		3 / 3 LYS A 287
PRO A 288
SER A 289
 None
 0.26A 4k50I-3un6A:
undetectable		 4k50I-3un6A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		6 / 12 LEU A  82
LEU A  78
GLY A  40
LEU A  50
VAL A 222
ILE A  37
 None
 1.25A 4ok1A-3un6A:
undetectable		 4ok1A-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 LEU A  78
GLY A  40
LEU A  50
VAL A 222
ILE A  37
 None
 1.33A 4okbA-3un6A:
undetectable		 4okbA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 LEU A  82
LEU A  78
GLY A  40
VAL A 222
ILE A  37
 None
 1.24A 4oktA-3un6A:
undetectable		 4oktA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 LEU A  82
LEU A  78
GLY A  40
LEU A  50
VAL A 222
 None
 1.34A 4olmA-3un6A:
undetectable		 4olmA-3un6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 LEU A  93
LEU A  96
ALA A  97
LEU A  78
HIS A 114
 None
None
None
None
ZN  A 325 ( 4.9A)
 1.11A 4pxmA-3un6A:
undetectable		 4pxmA-3un6A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 8 GLY A 199
GLU A 200
GLU A 193
ALA A 192
 None
None
None
ZN  A 326 ( 3.8A)
 0.88A 4rjdA-3un6A:
undetectable
4rjdB-3un6A:
undetectable		 4rjdA-3un6A:
11.83
4rjdB-3un6A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 GLY A 211
THR A 207
ASP A 212
ILE A 215
GLU A 293
 None
 1.15A 5bw4A-3un6A:
undetectable		 5bw4A-3un6A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		4 / 7 HIS A 264
ASP A 243
TYR A 244
HIS A 263
 None
 1.06A 5iy5A-3un6A:
undetectable
5iy5C-3un6A:
undetectable		 5iy5A-3un6A:
23.14
5iy5C-3un6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 ILE A 142
HIS A 149
ASN A 118
HIS A 144
LEU A  96
 None
ZN  A 326 ( 4.6A)
ZN  A 325 ( 4.7A)
PO4  A 329 (-3.8A)
None
 1.37A 6chgC-3un6A:
undetectable		 6chgC-3un6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 12 VAL A 222
SER A  91
THR A  92
PHE A 312
TYR A 244
 None
 1.29A 6drxA-3un6A:
undetectable		 6drxA-3un6A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 11 LEU A 225
GLY A  85
PHE A 240
ILE A  37
ILE A  39
 None
 1.06A 6ebzA-3un6A:
undetectable		 6ebzA-3un6A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 11 LEU A 225
GLY A  85
PHE A 240
ILE A  37
ILE A  39
 None
 1.05A 6ebzB-3un6A:
undetectable		 6ebzB-3un6A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3un6 HYPOTHETICAL PROTEIN
SAOUHSC_00137
(Staphylococcus
aureus) 		5 / 11 PHE A 312
ALA A  97
THR A 148
LEU A 151
ALA A 218
 None
 1.22A 6efnA-3un6A:
undetectable		 6efnA-3un6A:
21.68