SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 231
ASN A 157
VAL A 144
GLY A 155
LEU A 235
 None
 1.34A 1fkpA-3uoeA:
undetectable		 1fkpA-3uoeA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  20
VAL A  21
LEU A  56
LEU A  53
ALA A  26
 None
 1.35A 1pbcA-3uoeA:
undetectable		 1pbcA-3uoeA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 LEU A  52
LEU A  15
SER A  12
LEU A  46
 None
 1.13A 1ya3A-3uoeA:
undetectable		 1ya3A-3uoeA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A 126
ASP A 130
GLU A 125
ARG A  39
 None
 1.21A 2ouzA-3uoeA:
undetectable		 2ouzA-3uoeA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A  46
LEU A  33
ALA A  36
HIS A 116
 None
 0.91A 2wekA-3uoeA:
undetectable		 2wekA-3uoeA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 1.01A 3mteB-3uoeA:
undetectable		 3mteB-3uoeA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 0.88A 3p2kB-3uoeA:
undetectable		 3p2kB-3uoeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 0.90A 3p2kC-3uoeA:
undetectable		 3p2kC-3uoeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  84
PRO A  87
VAL A  88
LEU A  60
LEU A  52
 None
 0.94A 3p2kD-3uoeA:
undetectable		 3p2kD-3uoeA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		6 / 11 TYR A 227
HIS A 145
GLY A 149
GLY A 204
ALA A 199
ALA A 213
 None
 1.42A 3sufC-3uoeA:
undetectable		 3sufC-3uoeA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A  33
ASP A 263
HIS A 116
GLY A  86
GLY A  81
 None
 1.10A 4blvA-3uoeA:
undetectable		 4blvA-3uoeA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 268
GLY A 275
GLY A 273
ILE A 277
ALA A 279
 None
 0.84A 4kicB-3uoeA:
undetectable		 4kicB-3uoeA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 SER A 138
GLY A  67
ASP A  80
GLY A  84
 None
 0.90A 4koeA-3uoeA:
undetectable
4koeB-3uoeA:
undetectable
4koeC-3uoeA:
undetectable		 4koeA-3uoeA:
20.68
4koeB-3uoeA:
20.68
4koeC-3uoeA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 182
LEU A 253
ASN A 157
SER A 177
ILE A 218
 None
 1.28A 4pb1A-3uoeA:
undetectable		 4pb1A-3uoeA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 PRO A  50
LEU A  53
GLN A  29
 None
 0.63A 4pevB-3uoeA:
undetectable		 4pevB-3uoeA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 316
ALA A 314
LEU A  34
ARG A   9
GLY A  40
 None
 1.00A 4xi3B-3uoeA:
undetectable		 4xi3B-3uoeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 316
ALA A 314
LEU A  34
ARG A   9
GLY A  40
 None
 1.04A 4xi3C-3uoeA:
undetectable		 4xi3C-3uoeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 THR A 316
ALA A 314
LEU A  34
ARG A   9
GLY A  40
 None
 1.09A 5gs4A-3uoeA:
undetectable		 5gs4A-3uoeA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A  64
PRO A  22
ASP A  24
 None
 0.75A 5l8dB-3uoeA:
undetectable		 5l8dB-3uoeA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A  64
PRO A  22
ASP A  24
 None
 0.75A 5mwuB-3uoeA:
undetectable		 5mwuB-3uoeA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3uoe DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 MET A 137
ALA A 239
LEU A 240
ALA A 110
 None
 1.17A 6fosB-3uoeA:
undetectable		 6fosB-3uoeA:
14.33