SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uow'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 PHE A 181
LEU A  79
PHE A  75
LEU A  70
LEU A  55
 None
 1.08A 1dtlA-3uowA:
undetectable		 1dtlA-3uowA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 290
ASP A 288
ILE A 287
PHE A 286
ALA A 260
 None
 1.26A 1oltA-3uowA:
undetectable		 1oltA-3uowA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 LYS A   6
ASP A 236
ASP A 413
 None
 1.15A 2br4A-3uowA:
2.5		 2br4A-3uowA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 MET A 220
PHE A 156
PHE A  86
GLY A 204
VAL A 184
 None
 1.42A 2fqyA-3uowA:
3.6		 2fqyA-3uowA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 PHE A 433
GLY A 435
PHE A 286
GLY A 264
VAL A 300
 None
XMP  A 556 (-4.1A)
None
None
None
 1.33A 2fqyA-3uowA:
3.6		 2fqyA-3uowA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 PHE A 433
GLY A 437
PHE A 286
GLY A 264
VAL A 300
 None
 1.20A 2fqyA-3uowA:
3.6		 2fqyA-3uowA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 10 GLY A 437
LEU A 438
SER A 262
ASN A 289
PHE A 343
 None
 1.45A 2h21A-3uowA:
undetectable		 2h21A-3uowA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 6 TRP A 167
GLU A 213
SER A 508
THR A 512
 None
 1.47A 3ropA-3uowA:
2.9		 3ropA-3uowA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 PHE A 286
ASN A 289
LEU A 292
PHE A 433
 None
 1.03A 3rqwC-3uowA:
2.0
3rqwD-3uowA:
2.1		 3rqwC-3uowA:
20.14
3rqwD-3uowA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 PHE A 286
ASN A 289
LEU A 292
PHE A 433
 None
 1.03A 3rqwI-3uowA:
undetectable
3rqwJ-3uowA:
undetectable		 3rqwI-3uowA:
20.14
3rqwJ-3uowA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 8 LEU A 292
PHE A 433
PHE A 286
ASN A 289
 None
 1.05A 3rqwF-3uowA:
undetectable
3rqwJ-3uowA:
undetectable		 3rqwF-3uowA:
20.14
3rqwJ-3uowA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 LEU A 368
LEU A 417
GLN A 365
GLU A 244
 None
 1.24A 4i41A-3uowA:
undetectable		 4i41A-3uowA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 TYR A 520
ILE A 522
TYR A 542
ILE A 518
 None
 1.06A 4jtpA-3uowA:
undetectable		 4jtpA-3uowA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 PHE A  19
GLY A  91
GLY A  57
ALA A  96
ILE A 195
 None
 1.04A 4krhB-3uowA:
2.6		 4krhB-3uowA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 259
GLY A 366
LEU A 409
LEU A 368
GLU A 242
 None
 0.96A 4lg1A-3uowA:
undetectable		 4lg1A-3uowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 259
GLY A 366
LEU A 409
LEU A 368
TYR A 273
 None
 1.11A 4lg1A-3uowA:
undetectable		 4lg1A-3uowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 259
GLY A 366
LEU A 409
LEU A 368
GLU A 242
 None
 0.94A 4lg1B-3uowA:
undetectable		 4lg1B-3uowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 ALA A 259
GLY A 366
LEU A 409
LEU A 368
TYR A 273
 None
 1.10A 4lg1B-3uowA:
undetectable		 4lg1B-3uowA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		3 / 3 ASN A 227
PHE A 156
TYR A 196
 None
 0.78A 4u15A-3uowA:
undetectable		 4u15A-3uowA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
 1.13A 5d4uA-3uowA:
2.3		 5d4uA-3uowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 GLY A 204
LEU A  55
ILE A 192
LEU A 183
GLY A  57
 None
 1.10A 5d4uB-3uowA:
2.3		 5d4uB-3uowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		5 / 12 TYR A 273
PHE A 282
PHE A 406
THR A 307
LEU A 423
 None
 1.28A 5v5zA-3uowA:
undetectable		 5v5zA-3uowA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 LEU A 409
TYR A 408
LYS A 407
GLU A 244
 None
 1.31A 5weaA-3uowA:
3.0		 5weaA-3uowA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 4 GLU A 213
VAL A 211
LEU A  21
THR A 512
 None
 1.00A 6dynA-3uowA:
undetectable		 6dynA-3uowA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3uow GMP SYNTHETASE
(Plasmodium
falciparum) 		4 / 5 GLU A 213
VAL A 211
LEU A  21
THR A 512
 None
 1.00A 6dyoA-3uowA:
undetectable		 6dyoA-3uowA:
9.19