SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3up1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_A_NCAA303_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 9 HIS A 160
ASP A 146
TRP A 200
SER A 203
GLU A 182
 None
 1.27A 1ismA-3up1A:
undetectable		 1ismA-3up1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 8 HIS A 145
VAL A 147
VAL A 185
THR A 166
 None
 0.87A 2gehA-3up1A:
undetectable		 2gehA-3up1A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 TRP A 158
VAL A 117
ARG A 120
 None
None
GOL  A 906 ( 4.5A)
 0.78A 3b0wA-3up1A:
undetectable		 3b0wA-3up1A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 4 GLN A 151
ALA A 179
GLN A 176
THR A 208
 None
 1.44A 5hhjB-3up1A:
undetectable		 5hhjB-3up1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 PHE A 193
VAL A 107
HIS A  33
THR A 104
 None
 1.06A 5vkqA-3up1A:
undetectable
5vkqD-3up1A:
undetectable		 5vkqA-3up1A:
8.85
5vkqD-3up1A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 THR A 104
PHE A 193
VAL A 107
HIS A  33
 None
 1.08A 5vkqA-3up1A:
undetectable
5vkqB-3up1A:
undetectable		 5vkqA-3up1A:
8.85
5vkqB-3up1A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 8 THR A 104
PHE A 193
VAL A 107
HIS A  33
 None
 1.06A 5vkqB-3up1A:
undetectable
5vkqC-3up1A:
undetectable		 5vkqB-3up1A:
8.85
5vkqC-3up1A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3up1 INTERLEUKIN-7
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 THR A 104
PHE A 193
VAL A 107
HIS A  33
 None
 1.05A 5vkqC-3up1A:
undetectable
5vkqD-3up1A:
undetectable		 5vkqC-3up1A:
8.85
5vkqD-3up1A:
8.85