SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3up4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 10 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.92A 1fohA-3up4A:
8.7		 1fohA-3up4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 10 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.93A 1fohB-3up4A:
7.1		 1fohB-3up4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 10 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.93A 1fohD-3up4A:
6.6		 1fohD-3up4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 THR A 222
PRO A 223
LEU A 305
PHE A 333
 None
 0.84A 1h4oG-3up4A:
undetectable		 1h4oG-3up4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 9 GLY A 192
VAL A 356
GLY A 189
ILE A 383
ILE A 358
 NAP  A 552 (-3.4A)
None
None
None
None
 0.99A 1hpvA-3up4A:
undetectable		 1hpvA-3up4A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 10 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.93A 1pn0A-3up4A:
6.1		 1pn0A-3up4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 10 GLY A 192
VAL A 190
ILE A 201
TYR A 344
GLY A 194
 NAP  A 552 (-3.4A)
None
None
None
NAP  A 552 (-3.4A)
 0.92A 1pn0B-3up4A:
7.0		 1pn0B-3up4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 ILE A 363
ALA A 361
PHE A 214
ARG A 187
LEU A 380
 None
 1.04A 1rx8A-3up4A:
undetectable		 1rx8A-3up4A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 ILE A 201
ALA A 204
ASN A 343
LEU A 211
ALA A 208
 None
 1.11A 1xdkA-3up4A:
undetectable		 1xdkA-3up4A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 TYR A 539
SER A 441
GLN A 424
PHE A 432
ILE A 140
 None
 1.44A 1xosA-3up4A:
undetectable		 1xosA-3up4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 VAL A 198
GLY A  55
TYR A 344
TRP A 170
ARG A  52
 None
 1.26A 2cl5B-3up4A:
1.6		 2cl5B-3up4A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 THR A  47
TYR A  49
ILE A  15
GLY A  16
GLY A  18
 FAD  A 551 (-3.3A)
None
None
FAD  A 551 (-3.2A)
FAD  A 551 (-2.9A)
 0.98A 2fk8A-3up4A:
undetectable		 2fk8A-3up4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 GLY A 436
HIS A 438
ALA A 142
THR A 143
ALA A 454
 None
None
None
FAD  A 551 ( 4.3A)
None
 1.06A 2gluA-3up4A:
2.5		 2gluA-3up4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 VAL A 198
GLY A  55
TYR A 344
TRP A 170
ARG A  52
 None
 1.29A 2zvjA-3up4A:
2.6		 2zvjA-3up4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 VAL A 198
GLY A  55
TYR A 344
TRP A 170
ARG A  52
 None
 1.25A 3bwyA-3up4A:
undetectable		 3bwyA-3up4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 PHE A 276
GLU A 271
SER A 270
VAL A 267
 None
 1.19A 3dqtA-3up4A:
undetectable
3dqtB-3up4A:
undetectable		 3dqtA-3up4A:
21.53
3dqtB-3up4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 GLY A 192
ALA A 386
ILE A 383
ALA A 204
ILE A 200
 NAP  A 552 (-3.4A)
None
None
None
None
 0.98A 3ekwB-3up4A:
undetectable		 3ekwB-3up4A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 LEU A 544
ASN A 467
SER A 472
PHE A 138
 None
 1.50A 3i9jB-3up4A:
undetectable		 3i9jB-3up4A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 GLU A 485
LEU A 423
TRP A 456
ASN A 439
 None
 1.42A 3k8mB-3up4A:
undetectable		 3k8mB-3up4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 VAL A 188
LEU A 211
SER A 167
PHE A 165
GLY A 180
 None
None
NAP  A 552 ( 4.9A)
None
None
 1.13A 3kk6A-3up4A:
undetectable		 3kk6A-3up4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 VAL A 188
LEU A 211
SER A 167
PHE A 165
GLY A 180
 None
None
NAP  A 552 ( 4.9A)
None
None
 1.13A 3kk6B-3up4A:
undetectable		 3kk6B-3up4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 PHE A 160
ILE A 154
LEU A 380
PHE A 214
 None
 1.02A 3rqwI-3up4A:
undetectable
3rqwJ-3up4A:
undetectable		 3rqwI-3up4A:
19.43
3rqwJ-3up4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 11 THR A  20
GLY A  21
THR A 143
GLY A 144
PRO A 145
 FAD  A 551 (-3.2A)
None
FAD  A 551 ( 4.3A)
FAD  A 551 (-3.3A)
FAD  A 551 ( 4.3A)
 0.96A 3t8nD-3up4A:
undetectable
3t8nF-3up4A:
undetectable		 3t8nD-3up4A:
13.94
3t8nF-3up4A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 11 THR A 143
GLY A 144
PRO A 145
THR A  20
GLY A  21
 FAD  A 551 ( 4.3A)
FAD  A 551 (-3.3A)
FAD  A 551 ( 4.3A)
FAD  A 551 (-3.2A)
None
 0.97A 3t8nD-3up4A:
undetectable
3t8nF-3up4A:
undetectable		 3t8nD-3up4A:
13.94
3t8nF-3up4A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3up4 OTEMO
(Pseudomonas
putida) 		3 / 3 LYS A  71
ARG A 459
LEU A  27
 None
 1.36A 3v4tE-3up4A:
undetectable		 3v4tE-3up4A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 PHE A  68
ALA A  96
GLY A  45
VAL A  44
 None
 0.91A 4dubA-3up4A:
undetectable		 4dubA-3up4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 PHE A  68
ALA A  96
GLY A  45
VAL A  44
 None
 0.93A 4dubB-3up4A:
undetectable		 4dubB-3up4A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 5 SER A 441
HIS A 438
TYR A 527
VAL A 486
 None
 1.30A 4eohB-3up4A:
2.6		 4eohB-3up4A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 ASN A 219
TYR A 348
TYR A 344
LEU A 326
 None
 1.25A 4f8yA-3up4A:
3.5
4f8yB-3up4A:
3.1		 4f8yA-3up4A:
14.94
4f8yB-3up4A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 ASN A 540
ARG A 481
TYR A 420
LEU A 421
 None
 1.25A 4f8yA-3up4A:
3.5
4f8yB-3up4A:
3.1		 4f8yA-3up4A:
14.94
4f8yB-3up4A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3up4 OTEMO
(Pseudomonas
putida) 		3 / 3 PHE A 183
VAL A 382
GLU A 163
 None
 0.56A 4fvqA-3up4A:
undetectable		 4fvqA-3up4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 5 ILE A 327
ASP A 357
GLU A 324
VAL A 317
 None
 1.19A 4nkxC-3up4A:
undetectable		 4nkxC-3up4A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 GLY A 334
ALA A 335
SER A 290
TYR A 257
GLN A 282
 None
 1.31A 4rtpA-3up4A:
undetectable		 4rtpA-3up4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 CYH A 531
LYS A 529
GLU A 526
GLY A 524
 None
 0.98A 5a06D-3up4A:
2.4		 5a06D-3up4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 PHE A 276
GLU A 271
SER A 270
VAL A 267
 None
 1.14A 5adlA-3up4A:
undetectable
5adlB-3up4A:
undetectable		 5adlA-3up4A:
21.93
5adlB-3up4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 PRO A 145
HIS A 520
GLU A 526
LEU A 289
 FAD  A 551 ( 4.3A)
None
None
None
 0.99A 5igiA-3up4A:
undetectable		 5igiA-3up4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 LEU A 146
ILE A 200
THR A 196
TRP A 170
 NAP  A 552 (-4.2A)
None
NAP  A 552 (-3.5A)
None
 1.04A 5ljbA-3up4A:
undetectable		 5ljbA-3up4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 6 LEU A 146
ILE A 200
THR A 196
TRP A 170
 NAP  A 552 (-4.2A)
None
NAP  A 552 (-3.5A)
None
 1.08A 5ljeA-3up4A:
undetectable		 5ljeA-3up4A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3up4 OTEMO
(Pseudomonas
putida) 		5 / 12 TRP A 170
PHE A 183
ALA A 204
LEU A 211
ILE A 200
 None
 1.10A 5m24A-3up4A:
undetectable		 5m24A-3up4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3up4 OTEMO
(Pseudomonas
putida) 		3 / 3 THR A 143
THR A 110
LEU A  36
 FAD  A 551 ( 4.3A)
None
None
 0.62A 5m66D-3up4A:
2.8		 5m66D-3up4A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3up4 OTEMO
(Pseudomonas
putida) 		3 / 3 LEU A 297
LEU A 296
TRP A 288
 None
 0.85A 5nwuA-3up4A:
undetectable		 5nwuA-3up4A:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 GLU A 479
GLY A 422
GLN A 424
THR A 433
 None
 0.93A 5sxqA-3up4A:
undetectable		 5sxqA-3up4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 GLU A 479
GLY A 422
GLN A 424
THR A 433
 None
 0.90A 5sxqB-3up4A:
2.9		 5sxqB-3up4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 GLU A 479
GLY A 422
GLN A 424
THR A 433
 None
 0.97A 5sxtA-3up4A:
undetectable		 5sxtA-3up4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 8 GLU A 479
GLY A 422
GLN A 424
THR A 433
 None
 0.92A 5sxtB-3up4A:
undetectable		 5sxtB-3up4A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 LEU A 295
PHE A 333
THR A 222
THR A 493
 None
 0.99A 5vc0A-3up4A:
undetectable		 5vc0A-3up4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 SER A 270
VAL A 267
PHE A 276
GLU A 271
 None
 1.21A 6av6A-3up4A:
0.0
6av6B-3up4A:
undetectable		 6av6A-3up4A:
8.86
6av6B-3up4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 PHE A 276
GLU A 271
SER A 270
VAL A 267
 None
 1.22A 6av6C-3up4A:
undetectable
6av6D-3up4A:
undetectable		 6av6C-3up4A:
8.86
6av6D-3up4A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3up4 OTEMO
(Pseudomonas
putida) 		4 / 7 SER A 270
VAL A 267
PHE A 276
GLU A 271
 None
 1.14A 6av7A-3up4A:
0.0
6av7B-3up4A:
undetectable		 6av7A-3up4A:
8.86
6av7B-3up4A:
8.86