SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3up6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 8 VAL A  70
ASP A 101
ASP A 158
LEU A 125
 None
 1.23A 1pk2A-3up6A:
undetectable		 1pk2A-3up6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 8 PHE A 213
TYR A 132
GLY A 149
ILE A 107
 None
 0.77A 2a1mB-3up6A:
undetectable		 2a1mB-3up6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 6 ARG A 223
ILE A 331
ARG A 279
SER A 208
 None
 1.45A 3ckzA-3up6A:
undetectable		 3ckzA-3up6A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		3 / 3 GLU A 110
HIS A  77
THR A 115
 None
 0.85A 3hkuA-3up6A:
undetectable		 3hkuA-3up6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 6 THR A 340
GLN A 349
GLN A 338
ILE A 353
 None
 1.09A 3peoG-3up6A:
undetectable		 3peoG-3up6A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 8 SER A 273
PHE A 274
THR A 203
PHE A 183
 None
 1.05A 4drjB-3up6A:
undetectable		 4drjB-3up6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 6 ASN A 335
ALA A 178
THR A 276
LEU A 289
 None
 0.93A 4ejgD-3up6A:
undetectable		 4ejgD-3up6A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 6 SER A 113
SER A 116
ASP A 119
GLU A 110
 None
 1.26A 4eysA-3up6A:
undetectable		 4eysA-3up6A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		5 / 12 LEU A  43
ILE A  41
LEU A  39
LYS A 167
ILE A 156
 None
 0.93A 4y0rA-3up6A:
undetectable		 4y0rA-3up6A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		4 / 5 GLY A 221
THR A 222
ASN A 225
LYS A 230
 None
 1.05A 5x23A-3up6A:
undetectable		 5x23A-3up6A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3up6 HYPOTHETICAL PROTEIN
BACOVA_04078
(Bacteroides
ovatus) 		5 / 12 ILE A 291
ILE A 306
VAL A 339
THR A 340
ILE A 350
 None
 1.05A 6hlpA-3up6A:
undetectable		 6hlpA-3up6A:
20.19