SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3upu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ALA A  60
ILE A 138
GLY A 140
ILE A 141
ILE A  81
 None
 1.02A 1c6zB-3upuA:
undetectable		 1c6zB-3upuA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 253
ILE A 342
TRP A 323
 None
 1.14A 1m8eB-3upuA:
undetectable		 1m8eB-3upuA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ALA A  60
ILE A 138
GLY A 140
ILE A 141
ILE A  81
 None
 1.13A 1sduB-3upuA:
undetectable		 1sduB-3upuA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 THR A 329
VAL A 297
LEU A 325
ILE A 340
SER A 385
 None
 1.35A 2fj1A-3upuA:
undetectable		 2fj1A-3upuA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ASN A  31
TYR A 426
SER A 118
 None
 0.86A 2gvcB-3upuA:
undetectable		 2gvcB-3upuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ASN A  31
TYR A 426
SER A 118
 None
 0.83A 2gvcE-3upuA:
undetectable		 2gvcE-3upuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 9 ALA A 398
ALA A 406
GLY A 432
GLY A 428
ILE A 408
 None
 1.13A 2v7bA-3upuA:
undetectable		 2v7bA-3upuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 9 ALA A 398
ALA A 406
GLY A 432
GLY A 428
ILE A 408
 None
 1.13A 2v7bB-3upuA:
2.6		 2v7bB-3upuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 5 ILE A 252
PHE A 218
VAL A 186
PHE A 395
 None
 1.23A 2ygnA-3upuA:
undetectable		 2ygnA-3upuA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 ASP A 332
SER A  71
LYS A  72
ASP A 115
 None
 1.29A 3bc9A-3upuA:
undetectable		 3bc9A-3upuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 253
ILE A 342
TRP A 323
 None
 1.11A 3e68A-3upuA:
undetectable		 3e68A-3upuA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 253
ILE A 342
TRP A 323
 None
 1.14A 3e6tB-3upuA:
undetectable		 3e6tB-3upuA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 253
ILE A 342
TRP A 323
 None
 1.15A 3e7iB-3upuA:
undetectable		 3e7iB-3upuA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 5 THR A  29
PHE A 168
PHE A 125
TYR A 120
 None
 0.99A 3em0A-3upuA:
undetectable		 3em0A-3upuA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 11 ILE A 268
ALA A 389
PHE A 263
ILE A 340
VAL A 297
 None
 1.07A 3n0hA-3upuA:
undetectable		 3n0hA-3upuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 253
ILE A 342
TRP A 323
 None
 1.13A 3nw2A-3upuA:
undetectable		 3nw2A-3upuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.85A 3p50A-3upuA:
undetectable		 3p50A-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.85A 3p50B-3upuA:
undetectable		 3p50B-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.83A 3p50C-3upuA:
undetectable		 3p50C-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.86A 3p50D-3upuA:
undetectable		 3p50D-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.85A 3p50E-3upuA:
undetectable		 3p50E-3upuA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 268
ALA A 389
PHE A 263
ILE A 340
VAL A 297
 None
 1.10A 3s3vA-3upuA:
undetectable		 3s3vA-3upuA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 5 SER A 402
ARG A 433
TYR A 434
VAL A 436
 None
 0.98A 3sufC-3upuA:
undetectable		 3sufC-3upuA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 HIS A 204
GLY A 203
VAL A 206
ASP A 435
ASP A 404
 None
 1.08A 3sugA-3upuA:
undetectable		 3sugA-3upuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 HIS A 204
GLY A 203
VAL A 436
ASP A 435
ARG A 405
 None
 1.02A 3sugA-3upuA:
undetectable		 3sugA-3upuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.11A 3uboB-3upuA:
undetectable		 3uboB-3upuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 9 ALA A 398
ALA A 406
GLY A 432
GLY A 428
ILE A 408
 None
 1.08A 4eatB-3upuA:
3.0		 4eatB-3upuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.10A 4k8pB-3upuA:
undetectable		 4k8pB-3upuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.09A 4k9cB-3upuA:
undetectable		 4k9cB-3upuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.10A 4k9iA-3upuA:
undetectable		 4k9iA-3upuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.09A 4k9iB-3upuA:
undetectable		 4k9iB-3upuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		5 / 12 ILE A 141
GLY A 142
THR A  42
GLU A 116
THR A  36
 None
 1.10A 4kadB-3upuA:
undetectable		 4kadB-3upuA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		3 / 3 ARG A 337
GLU A 338
PHE A 291
 None
 0.99A 4kszA-3upuA:
undetectable		 4kszA-3upuA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 5 ILE A  45
LEU A  41
ASP A   4
GLU A  47
 None
 1.01A 4nkxB-3upuA:
undetectable		 4nkxB-3upuA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3upu ATP-DEPENDENT DNA
HELICASE DDA
(Escherichia
virus
T4) 		4 / 7 PRO A 104
ILE A  84
THR A 131
ILE A 132
 None
 0.82A 5murB-3upuA:
undetectable		 5murB-3upuA:
11.11