SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uqe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.78A 1bx4A-3uqeA:
25.3		 1bx4A-3uqeA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 10 THR A 300
CYH A 295
LEU A 264
PHE A 278
GLY A  52
 None
 1.29A 1h4oA-3uqeA:
undetectable
1h4oB-3uqeA:
undetectable		 1h4oA-3uqeA:
21.19
1h4oB-3uqeA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 10 LEU A 264
ALA A  47
VAL A 259
GLY A  40
GLY A  41
 None
 1.05A 1k6cA-3uqeA:
undetectable		 1k6cA-3uqeA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.73A 1likA-3uqeA:
24.8		 1likA-3uqeA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 7 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.07A 1rxcD-3uqeA:
undetectable		 1rxcD-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 LEU A 183
GLY A 279
CYH A 295
ALA A 261
ALA A  47
 None
 1.04A 2bm9C-3uqeA:
2.8		 2bm9C-3uqeA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 LEU A 183
GLY A 279
CYH A 295
ALA A 261
ALA A  47
 None
 1.05A 2bm9F-3uqeA:
3.1		 2bm9F-3uqeA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.79A 2c49A-3uqeA:
26.9		 2c49A-3uqeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 7 ASP A  14
GLY A  38
GLY A  39
ASN A  43
 None
 0.61A 2c49B-3uqeA:
28.0		 2c49B-3uqeA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A 255
GLY A  40
THR A   8
LEU A   9
ASP A 166
 ATP  A 401 (-3.3A)
None
None
None
MG  A 403 (-3.1A)
 1.07A 2oxtA-3uqeA:
undetectable		 2oxtA-3uqeA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.80A 2pkkA-3uqeA:
24.3		 2pkkA-3uqeA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.78A 2pkmA-3uqeA:
24.1		 2pkmA-3uqeA:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ALA A 230
GLY A 283
GLY A 226
ALA A 282
LEU A  51
 ATP  A 401 ( 4.1A)
ATP  A 401 (-3.2A)
ATP  A 401 (-3.2A)
None
None
 0.97A 2plwA-3uqeA:
2.9		 2plwA-3uqeA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 10 LEU A  69
ASP A  14
THR A   8
ASN A  43
ASP A 256
 None
 1.00A 2q58A-3uqeA:
undetectable		 2q58A-3uqeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 ALA A 282
SER A 224
GLY A 226
SER A 257
ALA A 254
 None
ATP  A 401 (-2.8A)
ATP  A 401 (-3.2A)
None
ATP  A 401 (-3.2A)
 1.46A 2vh3A-3uqeA:
undetectable		 2vh3A-3uqeA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 10 THR A 300
CYH A 295
LEU A 264
PHE A 278
GLY A  52
 None
 1.35A 2vl2A-3uqeA:
undetectable
2vl2C-3uqeA:
undetectable		 2vl2A-3uqeA:
22.61
2vl2C-3uqeA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		6 / 12 GLY A 255
GLY A  40
THR A   8
LEU A   9
ASP A 166
ILE A 136
 ATP  A 401 (-3.3A)
None
None
None
MG  A 403 (-3.1A)
None
 1.36A 2wa2B-3uqeA:
undetectable		 2wa2B-3uqeA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 VAL A 135
ILE A 164
LEU A  51
GLY A 279
ALA A 282
 None
 1.40A 2xf3B-3uqeA:
undetectable		 2xf3B-3uqeA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 VAL A 135
ILE A 164
LEU A  51
GLY A 279
ALA A 282
 None
 1.39A 2xfsB-3uqeA:
undetectable		 2xfsB-3uqeA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 VAL A 135
ILE A 164
LEU A  51
GLY A 279
ALA A 282
 None
 1.42A 2xh9B-3uqeA:
undetectable		 2xh9B-3uqeA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A 255
GLY A  40
THR A   8
LEU A   9
ASP A 166
 ATP  A 401 (-3.3A)
None
None
None
MG  A 403 (-3.1A)
 1.08A 3eluA-3uqeA:
undetectable		 3eluA-3uqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A 255
GLY A  40
THR A   8
LEU A   9
ASP A 166
 ATP  A 401 (-3.3A)
None
None
None
MG  A 403 (-3.1A)
 1.00A 3embA-3uqeA:
2.2		 3embA-3uqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.12A 3kvvA-3uqeA:
undetectable		 3kvvA-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.10A 3kvvB-3uqeA:
undetectable		 3kvvB-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.10A 3kvvC-3uqeA:
undetectable		 3kvvC-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.10A 3kvvD-3uqeA:
undetectable		 3kvvD-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.11A 3kvvE-3uqeA:
undetectable		 3kvvE-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.11A 3kvvF-3uqeA:
undetectable		 3kvvF-3uqeA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ARG A 105
 None
 0.74A 3uboA-3uqeA:
26.0		 3uboA-3uqeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.71A 3uboA-3uqeA:
26.0		 3uboA-3uqeA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.62A 3uq6A-3uqeA:
25.2		 3uq6A-3uqeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.57A 3vaqA-3uqeA:
25.0		 3vaqA-3uqeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.60A 3vasB-3uqeA:
19.1		 3vasB-3uqeA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 ASN A  43
GLY A  38
SER A 137
GLY A  41
ASP A 256
 None
 1.05A 3ztvA-3uqeA:
undetectable		 3ztvA-3uqeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		6 / 9 ASN A  43
GLY A  39
GLY A  38
SER A 137
GLY A  40
ASP A 256
 None
 1.11A 3ztvA-3uqeA:
undetectable		 3ztvA-3uqeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.79A 4dc3B-3uqeA:
25.0		 4dc3B-3uqeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.63A 4dc3B-3uqeA:
25.0		 4dc3B-3uqeA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 6 GLY A 260
MET A 275
ILE A  48
VAL A  44
 None
 1.15A 4e1vF-3uqeA:
undetectable		 4e1vF-3uqeA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.80A 4e3aB-3uqeA:
26.9		 4e3aB-3uqeA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 8 ASP A 116
VAL A 144
LEU A 121
LYS A 148
 None
 1.04A 4f8hA-3uqeA:
undetectable
4f8hB-3uqeA:
undetectable		 4f8hA-3uqeA:
22.38
4f8hB-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 8 ASP A 116
VAL A 144
LEU A 121
LYS A 148
 None
 1.03A 4f8hB-3uqeA:
undetectable
4f8hC-3uqeA:
undetectable		 4f8hB-3uqeA:
22.38
4f8hC-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 8 ASP A 116
VAL A 144
LEU A 121
LYS A 148
 None
 1.03A 4f8hC-3uqeA:
undetectable
4f8hD-3uqeA:
undetectable		 4f8hC-3uqeA:
22.38
4f8hD-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 8 ASP A 116
VAL A 144
LEU A 121
LYS A 148
 None
 1.03A 4f8hD-3uqeA:
undetectable
4f8hE-3uqeA:
undetectable		 4f8hD-3uqeA:
22.38
4f8hE-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 8 VAL A 144
LEU A 121
LYS A 148
ASP A 116
 None
 1.02A 4f8hA-3uqeA:
undetectable
4f8hE-3uqeA:
undetectable		 4f8hA-3uqeA:
22.38
4f8hE-3uqeA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 ASN A  43
GLY A  39
GLY A  38
GLY A  40
ASP A 256
 None
 0.70A 4h2fA-3uqeA:
undetectable		 4h2fA-3uqeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 9 ASN A  43
GLY A  39
GLY A  38
GLY A  40
ASP A 256
 None
 0.77A 4h2gA-3uqeA:
undetectable		 4h2gA-3uqeA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.72A 4jkuA-3uqeA:
15.5		 4jkuA-3uqeA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.71A 4jkuB-3uqeA:
27.1		 4jkuB-3uqeA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.71A 4k8cA-3uqeA:
24.8		 4k8cA-3uqeA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 PRO A 141
LEU A   9
GLY A 253
ASP A 256
THR A   8
 None
None
ATP  A 401 ( 4.1A)
None
None
 1.31A 4mubA-3uqeA:
undetectable		 4mubA-3uqeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 PRO A 141
LEU A   9
GLY A 255
ASP A 256
THR A   8
 None
None
ATP  A 401 (-3.3A)
None
None
 1.40A 4mubA-3uqeA:
undetectable		 4mubA-3uqeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.76A 4n09B-3uqeA:
26.6		 4n09B-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.50A 4n09B-3uqeA:
26.6		 4n09B-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.78A 4n09C-3uqeA:
26.4		 4n09C-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.52A 4n09C-3uqeA:
26.4		 4n09C-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 ASP A  14
GLY A  38
GLY A  39
ASN A  43
ASP A 256
 None
 0.76A 4n09D-3uqeA:
26.4		 4n09D-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 12 GLY A  38
GLY A  39
ASN A  43
GLY A 253
ASP A 256
 None
None
None
ATP  A 401 ( 4.1A)
None
 0.53A 4n09D-3uqeA:
26.4		 4n09D-3uqeA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 11 THR A  89
ALA A 111
GLY A  38
GLY A  39
SER A 139
 None
 1.07A 4qvwK-3uqeA:
undetectable
4qvwL-3uqeA:
undetectable		 4qvwK-3uqeA:
22.15
4qvwL-3uqeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		5 / 11 THR A  89
ALA A 111
GLY A  38
GLY A  39
SER A 139
 None
 1.07A 4qvwY-3uqeA:
undetectable
4qvwZ-3uqeA:
undetectable		 4qvwY-3uqeA:
22.15
4qvwZ-3uqeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 3uqe 6-PHOSPHOFRUCTOKINAS
E ISOZYME 2
(Escherichia
coli) 		4 / 5 ILE A 136
GLN A 157
CYH A 163
GLU A 182
 None
 1.47A 5fseC-3uqeA:
2.3		 5fseC-3uqeA:
21.17