SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 9 TYR A   9
GLY A 195
GLU A 198
PHE A 203
ILE A   8
 None
 1.23A 1oltA-3uqzA:
0.0		 1oltA-3uqzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 LEU A 180
LEU A 142
GLY A 145
ASP A 147
ALA A 149
 None
 1.13A 2br4E-3uqzA:
undetectable		 2br4E-3uqzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		4 / 8 GLY A 113
THR A 148
ALA A 149
ALA A 150
 None
 0.57A 2ej3A-3uqzA:
undetectable		 2ej3A-3uqzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 ILE A 247
ALA A 222
ALA A 150
LEU A 132
ILE A 138
 None
 1.14A 2h77A-3uqzA:
undetectable		 2h77A-3uqzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 ILE A 211
GLY A 166
ALA A 207
VAL A 171
VAL A 190
 None
 1.25A 2yvlC-3uqzA:
undetectable		 2yvlC-3uqzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 ILE A 211
GLY A 166
ALA A 207
VAL A 171
VAL A 190
 None
 1.20A 2yvlD-3uqzA:
undetectable		 2yvlD-3uqzA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 9 VAL A 128
PHE A 245
ILE A 220
ALA A 278
VAL A 109
 None
 1.28A 3me6D-3uqzA:
undetectable		 3me6D-3uqzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		4 / 5 ARG A 210
VAL A 164
LEU A 191
SER A 192
 None
 0.90A 4e1gA-3uqzA:
undetectable		 4e1gA-3uqzA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 ILE A 247
ALA A 222
ALA A 150
LEU A 132
ILE A 138
 None
 1.17A 4lnwA-3uqzA:
undetectable		 4lnwA-3uqzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		4 / 5 ARG A 227
ASP A 257
GLU A 235
VAL A 244
 None
 1.45A 4nkvB-3uqzA:
undetectable		 4nkvB-3uqzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		3 / 3 ARG A 208
PRO A 206
TYR A 173
 None
 1.01A 5tzoB-3uqzA:
undetectable		 5tzoB-3uqzA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 9 HIS A 204
GLY A 168
LEU A 180
LYS A 178
ASP A 147
 None
None
None
SO4  A 302 (-4.0A)
None
 1.36A 6c2mC-3uqzA:
undetectable		 6c2mC-3uqzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 SER A 140
LEU A 255
ASP A 147
GLY A 145
ILE A 138
 None
 1.21A 6dwnA-3uqzA:
undetectable		 6dwnA-3uqzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 12 SER A 140
LEU A 255
ASP A 147
GLY A 145
ILE A 138
 None
 1.14A 6dwnC-3uqzA:
undetectable		 6dwnC-3uqzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		5 / 9 ILE A   3
GLN A  33
GLU A  29
VAL A  24
ILE A  40
 None
 1.34A 6hloA-3uqzA:
5.6		 6hloA-3uqzA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3uqz DNA PROCESSING
PROTEIN DPRA
(Streptococcus
pneumoniae) 		4 / 8 ASP A 243
ARG A 242
ASP A  84
GLU A  87
 None
 1.08A 6mn4B-3uqzA:
undetectable		 6mn4B-3uqzA:
23.31