SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ure'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 8 THR A 143
GLY A 191
GLY A  19
SER A  43
 None
 0.76A 1jhaA-3ureA:
undetectable		 1jhaA-3ureA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
SO4  A 304 (-2.8A)
None
 0.90A 1rqpC-3ureA:
undetectable		 1rqpC-3ureA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
SO4  A 304 (-2.8A)
None
 0.89A 1rqpA-3ureA:
undetectable		 1rqpA-3ureA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		3 / 3 ALA A  55
VAL A  53
TRP A 105
 None
 1.02A 1tkqA-3ureA:
undetectable		 1tkqA-3ureA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 7 GLY A  56
SER A 214
PHE A  94
ARG A  90
 None
 0.97A 2c8aB-3ureA:
undetectable		 2c8aB-3ureA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 7 GLY A  56
SER A 214
PHE A  94
ARG A  90
 None
 0.96A 2c8aD-3ureA:
undetectable		 2c8aD-3ureA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
 None
None
SO4  A 304 (-2.8A)
None
 0.89A 2v7uA-3ureA:
undetectable		 2v7uA-3ureA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 11 ILE A 210
LEU A 180
ASN A 101
LEU A 199
THR A 163
 None
 1.20A 3a50B-3ureA:
undetectable		 3a50B-3ureA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		3 / 3 GLY A 197
GLY A  18
GLY A  44
 None
 0.41A 3bogC-3ureA:
undetectable		 3bogC-3ureA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 11 ILE A  31
ILE A  66
GLY A  67
PHE A  52
VAL A 106
 None
 1.00A 4ac9B-3ureA:
2.7
4ac9C-3ureA:
3.1		 4ac9B-3ureA:
16.60
4ac9C-3ureA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 5 ILE A  35
ALA A  39
HIS A  57
ARG A 192
 None
None
SO4  A 304 (-3.8A)
None
 1.11A 4ac9B-3ureA:
2.7
4ac9C-3ureA:
3.1		 4ac9B-3ureA:
16.60
4ac9C-3ureA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 5 ILE A  35
ALA A  39
HIS A  57
ARG A 192
 None
None
SO4  A 304 (-3.8A)
None
 1.11A 4acaB-3ureA:
2.9
4acaC-3ureA:
3.2		 4acaB-3ureA:
16.60
4acaC-3ureA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 SER A  43
GLY A 215
GLY A 196
GLY A 197
VAL A 218
 None
 0.92A 4b17A-3ureA:
undetectable		 4b17A-3ureA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 4 TYR A  33
THR A  87
VAL A  84
ILE A  35
 None
 1.36A 4jx1F-3ureA:
undetectable		 4jx1F-3ureA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 GLY A 197
GLY A 140
ASN A 120
SER A  43
ALA A  55
 None
 1.02A 4uciA-3ureA:
undetectable		 4uciA-3ureA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 5 ILE A 234
LEU A 108
GLY A  51
PHE A  52
 None
 0.94A 5kmdC-3ureA:
undetectable
5kmdD-3ureA:
undetectable		 5kmdC-3ureA:
20.96
5kmdD-3ureA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 LEU A 242
ALA A 209
SER A 198
ILE A 234
LEU A 180
 None
 1.24A 5ljbA-3ureA:
undetectable		 5ljbA-3ureA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 LEU A 242
ALA A 209
SER A 198
ILE A 234
LEU A 180
 None
 1.28A 5ljcA-3ureA:
undetectable		 5ljcA-3ureA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ure ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 VAL A  17
GLY A  19
SER A  43
PHE A  88
VAL A  84
 None
 1.45A 6a94A-3ureA:
undetectable		 6a94A-3ureA:
19.20