SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3urh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A   9
TYR A  15
ALA A 142
GLU A 327
 FAD  A 500 (-3.2A)
None
FAD  A 500 (-4.8A)
None
 0.87A 1dmaA-3urhA:
undetectable		 1dmaA-3urhA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 155
GLY A 149
THR A 273
ILE A 271
 None
 0.81A 1gtnC-3urhA:
undetectable
1gtnD-3urhA:
undetectable		 1gtnC-3urhA:
11.51
1gtnD-3urhA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 GLU A  57
HIS A  60
ASP A 396
 None
 0.78A 1i9gA-3urhA:
2.8		 1i9gA-3urhA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 334
GLY A 330
ILE A 336
ALA A 338
ILE A  19
 None
 1.13A 1ve3B-3urhA:
undetectable		 1ve3B-3urhA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.11A 1vidA-3urhA:
undetectable		 1vidA-3urhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 VAL A 374
TYR A 376
THR A 365
LEU A 411
 None
 0.92A 1z2bB-3urhA:
undetectable		 1z2bB-3urhA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.11A 2cl5B-3urhA:
undetectable		 2cl5B-3urhA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 291
VAL A 317
ILE A 313
ILE A   8
VAL A 297
 None
None
None
FAD  A 500 (-4.8A)
None
 1.08A 2nnpB-3urhA:
undetectable		 2nnpB-3urhA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 180
GLY A 184
ALA A 195
VAL A 203
GLY A 187
 None
 0.87A 2v0zO-3urhA:
undetectable		 2v0zO-3urhA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.17A 2zvjA-3urhA:
undetectable		 2zvjA-3urhA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLN A 356
GLU A 358
THR A 355
PHE A 383
GLY A 397
 None
 1.36A 3ag4A-3urhA:
0.6
3ag4B-3urhA:
undetectable
3ag4T-3urhA:
undetectable		 3ag4A-3urhA:
21.90
3ag4B-3urhA:
16.27
3ag4T-3urhA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 THR A 449
SER A 451
PHE A 418
 None
 0.77A 3d4sA-3urhA:
undetectable		 3d4sA-3urhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 181
GLY A 182
GLY A 184
GLU A 205
ILE A 150
 None
 0.87A 3fuuA-3urhA:
3.0		 3fuuA-3urhA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A  12
GLY A  11
GLY A  38
VAL A 331
ASP A 328
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.2A)
None
None
None
 1.10A 3m6vA-3urhA:
2.5		 3m6vA-3urhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A  12
GLY A  11
GLY A  38
VAL A 331
ASP A 328
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.2A)
None
None
None
 1.09A 3m6vB-3urhA:
2.7		 3m6vB-3urhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A  12
GLY A  11
GLY A  38
VAL A 331
ASP A 328
 FAD  A 500 (-3.2A)
FAD  A 500 (-3.2A)
None
None
None
 1.08A 3m6wA-3urhA:
2.9		 3m6wA-3urhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 GLN A 304
THR A 305
LEU A   5
 None
 0.74A 3ondA-3urhA:
4.2		 3ondA-3urhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 GLN A 304
THR A 305
LEU A   5
 None
 0.75A 3ondB-3urhA:
3.8		 3ondB-3urhA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 193
GLY A 167
ALA A 168
SER A 165
LEU A 190
 None
None
None
FAD  A 500 (-3.5A)
None
 1.28A 3pghA-3urhA:
undetectable		 3pghA-3urhA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 216
VAL A 218
ASP A 215
THR A 365
 None
 0.94A 3vqrA-3urhA:
11.7		 3vqrA-3urhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 GLY A 216
VAL A 218
ASP A 215
THR A 365
 None
 0.94A 3vqrB-3urhA:
12.5		 3vqrB-3urhA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9A-3urhA:
undetectable		 4fp9A-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9C-3urhA:
undetectable		 4fp9C-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.92A 4fp9D-3urhA:
undetectable		 4fp9D-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.93A 4fp9F-3urhA:
undetectable		 4fp9F-3urhA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 246
LEU A 270
GLY A 167
PRO A 175
LEU A 171
 None
 0.94A 4fzvA-3urhA:
undetectable		 4fzvA-3urhA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 ALA A 156
VAL A 243
GLY A 248
THR A 161
 None
 1.02A 4ubeA-3urhA:
4.8		 4ubeA-3urhA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 VAL A 399
ALA A 420
PHE A 383
 None
 0.91A 4w5nA-3urhA:
undetectable		 4w5nA-3urhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 169
PRO A  48
LEU A 190
GLU A 189
 None
None
None
FAD  A 500 ( 4.5A)
 1.07A 4z4fA-3urhA:
undetectable		 4z4fA-3urhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A 188
VAL A 185
GLY A  45
LEU A  53
SER A 192
 None
None
FAD  A 500 (-3.4A)
None
None
 1.19A 4zbqA-3urhA:
undetectable		 4zbqA-3urhA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 GLU A  57
HIS A  60
ASP A 396
 None
 0.65A 5c0oG-3urhA:
3.0		 5c0oG-3urhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A 401
ALA A 360
VAL A 362
VAL A 454
 None
 0.90A 5ecnD-3urhA:
undetectable		 5ecnD-3urhA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 5 SER A  56
GLU A 189
TYR A 354
SER A 165
 None
FAD  A 500 ( 4.5A)
FAD  A 500 (-4.5A)
FAD  A 500 (-3.5A)
 1.11A 5fhrA-3urhA:
undetectable		 5fhrA-3urhA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 SER A  49
GLY A 167
ALA A 168
SER A 164
LEU A 270
 FAD  A 500 ( 3.8A)
None
None
None
None
 1.02A 5jvzB-3urhA:
undetectable		 5jvzB-3urhA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 SER A  49
GLY A 167
ALA A 168
SER A 164
LEU A 270
 FAD  A 500 ( 3.8A)
None
None
None
None
 1.05A 5kirB-3urhA:
undetectable		 5kirB-3urhA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 7 LEU A 169
PRO A  48
LEU A 190
GLU A 189
 None
None
None
FAD  A 500 ( 4.5A)
 1.08A 5t7bA-3urhA:
undetectable		 5t7bA-3urhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A 233
LEU A 222
THR A 355
SER A 192
VAL A 180
 None
 1.49A 5v1tA-3urhA:
undetectable		 5v1tA-3urhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 6 GLY A 198
SER A  56
VAL A 174
TRP A 194
 None
 1.04A 5ysiA-3urhA:
undetectable		 5ysiA-3urhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3urh DIHYDROLIPOYL
DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 182
GLY A 184
GLU A 205
THR A 273
ILE A 150
 None
 0.77A 6exiB-3urhA:
3.5		 6exiB-3urhA:
10.55