SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3us8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 GLY A  68
THR A 295
THR A 300
ILE A  64
 None
 0.92A 1gtnD-3us8A:
undetectable
1gtnE-3us8A:
undetectable		 1gtnD-3us8A:
12.77
1gtnE-3us8A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 5 GLU A  12
TYR A  41
SER A 330
ASP A  28
 None
 1.06A 1vidA-3us8A:
undetectable		 1vidA-3us8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 GLU A  12
TYR A  41
SER A 330
ASP A  28
 None
 1.07A 2cl5B-3us8A:
undetectable		 2cl5B-3us8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 ARG A 100
ASP A 277
SER A 276
SER A 291
 SO4  A 501 ( 4.8A)
None
None
None
 0.90A 2j2pA-3us8A:
undetectable
2j2pC-3us8A:
undetectable		 2j2pA-3us8A:
18.37
2j2pC-3us8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 ARG A 100
ASP A 277
SER A 276
SER A 291
 SO4  A 501 ( 4.8A)
None
None
None
 0.88A 2j2pD-3us8A:
undetectable
2j2pF-3us8A:
undetectable		 2j2pD-3us8A:
18.37
2j2pF-3us8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 LEU A  44
LEU A  13
SER A  94
PRO A  95
GLY A  97
 None
None
SO4  A 501 (-2.3A)
SO4  A 501 ( 4.7A)
None
 1.03A 2vmyA-3us8A:
undetectable		 2vmyA-3us8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 SER A 276
GLU A 304
ASP A 273
 None
 0.73A 2zthA-3us8A:
2.5		 2zthA-3us8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 SER A 276
GLU A 304
ASP A 273
 None
 0.73A 3bwmA-3us8A:
undetectable		 3bwmA-3us8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 SER A 276
GLU A 304
ASP A 273
 None
 0.75A 3bwyA-3us8A:
2.4		 3bwyA-3us8A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 LEU A 377
GLY A 284
SER A 285
LEU A 288
LEU A 120
 None
 1.11A 3e23A-3us8A:
undetectable		 3e23A-3us8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 8 VAL A  69
VAL A   6
HIS A 340
VAL A 301
 None
 1.02A 3fhxB-3us8A:
4.5		 3fhxB-3us8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 ASN A 182
SER A 186
GLY A 272
ILE A 107
GLU A 304
 None
 1.06A 3jb2A-3us8A:
2.1		 3jb2A-3us8A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 ILE A  76
VAL A  46
ARG A  49
 None
 0.75A 3p73A-3us8A:
undetectable		 3p73A-3us8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.92A 3vqrA-3us8A:
undetectable		 3vqrA-3us8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 5 ASP A  14
GLY A  45
ASP A  16
THR A  75
 None
 0.93A 3vqrB-3us8A:
undetectable		 3vqrB-3us8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 PHE A 225
ALA A 191
GLY A 131
VAL A 106
 None
 0.97A 4dubA-3us8A:
undetectable		 4dubA-3us8A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 7 GLU A  85
GLU A  47
ARG A  49
ARG A  82
 None
 1.02A 4fgzA-3us8A:
undetectable		 4fgzA-3us8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 8 PRO A  95
ARG A 100
VAL A  46
GLY A  45
 SO4  A 501 ( 4.7A)
SO4  A 501 ( 4.8A)
None
None
 0.65A 4mk4A-3us8A:
4.1		 4mk4A-3us8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 ASP A 277
ASP A 273
SER A  94
ALA A 306
 None
None
SO4  A 501 (-2.3A)
None
 1.06A 4nedA-3us8A:
undetectable		 4nedA-3us8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 SER A 276
GLU A 304
ASP A 273
 None
 0.74A 4xudA-3us8A:
undetectable		 4xudA-3us8A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 SER A 186
GLU A 185
GLY A 272
GLY A 131
 None
 0.85A 5cdnR-3us8A:
undetectable
5cdnS-3us8A:
2.9		 5cdnR-3us8A:
21.54
5cdnS-3us8A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 6 PHE A 229
SER A 194
ALA A 191
LEU A 207
 None
 1.29A 5dzkg-3us8A:
undetectable
5dzku-3us8A:
undetectable		 5dzkg-3us8A:
19.08
5dzku-3us8A:
0.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		4 / 5 GLU A  12
TYR A  41
SER A 330
ASP A  28
 None
 1.04A 5fhrA-3us8A:
undetectable		 5fhrA-3us8A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		3 / 3 HIS A 133
LYS A 268
PHE A 221
 None
 1.23A 5klaA-3us8A:
undetectable		 5klaA-3us8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 PHE A 390
ILE A 394
THR A 323
THR A 290
ALA A 305
 None
 1.26A 5vcgA-3us8A:
undetectable		 5vcgA-3us8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 THR A 290
VAL A 279
TYR A 197
CYH A 267
GLY A 272
 None
 1.43A 6gngB-3us8A:
2.8		 6gngB-3us8A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3us8 ISOCITRATE
DEHYDROGENASE [NADP]
(Sinorhizobium
meliloti) 		5 / 12 GLY A 104
LEU A 103
ASP A 184
ILE A 187
ASN A 101
 None
None
None
None
SO4  A 502 (-3.0A)
 0.80A 6mhtA-3us8A:
undetectable		 6mhtA-3us8A:
21.38