SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3us9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 8 GLY A 544
THR A 545
ALA A 546
VAL A 514
 None
 0.82A 2a1hA-3us9A:
undetectable
2a1hB-3us9A:
undetectable		 2a1hA-3us9A:
21.75
2a1hB-3us9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 10 THR A 541
GLY A 544
THR A 586
ALA A 546
VAL A 573
 None
 1.17A 2coiA-3us9A:
undetectable
2coiB-3us9A:
undetectable		 2coiA-3us9A:
21.72
2coiB-3us9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 10 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
 None
 1.17A 2coiA-3us9A:
undetectable
2coiB-3us9A:
undetectable		 2coiA-3us9A:
21.72
2coiB-3us9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 11 THR A 541
GLY A 544
THR A 586
ALA A 546
VAL A 573
 None
 1.16A 2cojA-3us9A:
undetectable
2cojB-3us9A:
undetectable		 2cojA-3us9A:
21.72
2cojB-3us9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		5 / 9 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
 None
 1.13A 2cojA-3us9A:
undetectable
2cojB-3us9A:
undetectable		 2cojA-3us9A:
21.72
2cojB-3us9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		3 / 3 ARG A 547
VAL A 573
THR A 541
 None
 0.85A 2nnkA-3us9A:
undetectable		 2nnkA-3us9A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		3 / 3 ARG A 547
VAL A 573
THR A 541
 None
 0.87A 3nduD-3us9A:
undetectable		 3nduD-3us9A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		3 / 3 ARG A 547
VAL A 573
THR A 541
 None
 0.85A 3pwrA-3us9A:
undetectable		 3pwrA-3us9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 5 ASP A 555
GLU A 554
GLY A 550
GLU A 543
 None
 1.42A 3w9tA-3us9A:
undetectable		 3w9tA-3us9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 5 ASP A 555
GLU A 554
GLY A 550
GLU A 543
 None
 1.42A 3w9tC-3us9A:
undetectable		 3w9tC-3us9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 5 ASP A 555
GLU A 554
GLY A 550
GLU A 543
 None
 1.41A 3w9tD-3us9A:
undetectable		 3w9tD-3us9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 3us9 SODIUM/CALCIUM
EXCHANGER 1
(Canis
lupus) 		4 / 5 ASP A 555
GLU A 554
GLY A 550
GLU A 543
 None
 1.41A 3w9tG-3us9A:
undetectable		 3w9tG-3us9A:
21.30