SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3usc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.72A 1a7yA-3uscL:
undetectable		 1a7yA-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.81A 1a7yB-3uscL:
undetectable		 1a7yB-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 CYH L  79
VAL L  78
HIS L  83
CYH L 579
 FCO  L 601 ( 2.3A)
3NI  L 602 ( 4.8A)
FCO  L 601 (-3.9A)
FCO  L 601 ( 2.3A)
 1.42A 1ekjG-3uscL:
undetectable
1ekjH-3uscL:
undetectable		 1ekjG-3uscL:
18.07
1ekjH-3uscL:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 VAL L 410
TYR L 548
PRO L 531
HIS L 119
GLU L 458
 None
None
FCO  L 601 (-3.5A)
None
None
 1.31A 1equA-3uscL:
undetectable		 1equA-3uscL:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 LEU L 152
MET L 201
LEU L 194
HIS L 205
 None
 0.83A 1errB-3uscL:
undetectable		 1errB-3uscL:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.72A 1i3wE-3uscL:
undetectable		 1i3wE-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.76A 1i3wE-3uscL:
undetectable		 1i3wE-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.72A 1i3wF-3uscL:
undetectable		 1i3wF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.76A 1i3wG-3uscL:
undetectable		 1i3wG-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.79A 1i3wG-3uscL:
undetectable		 1i3wG-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.79A 1i3wH-3uscL:
undetectable		 1i3wH-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ALA L  86
VAL L  88
TRP L 232
 None
 0.89A 1magA-3uscL:
undetectable		 1magA-3uscL:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ALA L  86
VAL L  88
TRP L 232
 None
 0.89A 1magB-3uscL:
undetectable		 1magB-3uscL:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 HIS L 205
ALA L 204
PHE L 203
GLY L 202
 None
 1.18A 1mj2B-3uscL:
undetectable		 1mj2B-3uscL:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 HIS L 205
ALA L 204
PHE L 203
GLY L 202
 None
 1.21A 1mj2D-3uscL:
undetectable		 1mj2D-3uscL:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 HIS L 205
ALA L 204
PHE L 203
GLY L 202
 None
 1.19A 1mjoB-3uscL:
0.2		 1mjoB-3uscL:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 HIS L 205
ALA L 204
PHE L 203
GLY L 202
 None
 1.20A 1mjoD-3uscL:
undetectable		 1mjoD-3uscL:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.72A 1mnvD-3uscL:
undetectable		 1mnvD-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.72A 1mnvD-3uscL:
undetectable		 1mnvD-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.74A 1ovfB-3uscL:
undetectable		 1ovfB-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 CYH L  79
ARG L 509
CYH L  76
 FCO  L 601 ( 2.3A)
FCO  L 601 (-4.2A)
3NI  L 602 (-2.2A)
 1.39A 1p9gA-3uscL:
undetectable		 1p9gA-3uscL:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.70A 1qfiA-3uscL:
undetectable		 1qfiA-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.84A 1qfiB-3uscL:
undetectable		 1qfiB-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ALA L  90
VAL L  88
TRP L  69
 None
 0.98A 1tkqA-3uscL:
undetectable		 1tkqA-3uscL:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ALA L 485
VAL L 234
TRP L  69
 None
 0.89A 1tkqB-3uscL:
undetectable		 1tkqB-3uscL:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.77A 1unjF-3uscL:
undetectable		 1unjF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.72A 1unjF-3uscL:
undetectable		 1unjF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.83A 1unjL-3uscL:
undetectable		 1unjL-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.81A 1unjL-3uscL:
undetectable		 1unjL-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.83A 1unjR-3uscL:
undetectable		 1unjR-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.78A 1unjR-3uscL:
undetectable		 1unjR-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.83A 1unjX-3uscL:
undetectable		 1unjX-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.81A 1unjX-3uscL:
undetectable		 1unjX-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.84A 1unmF-3uscL:
undetectable		 1unmF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 532
THR L 533
PRO L 531
 FCO  L 601 (-3.7A)
None
FCO  L 601 (-3.5A)
 0.83A 1unmF-3uscL:
undetectable		 1unmF-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 TRP L 515
ALA L 517
VAL L 502
 None
 0.93A 1w5uA-3uscL:
undetectable
1w5uB-3uscL:
undetectable		 1w5uA-3uscL:
5.26
1w5uB-3uscL:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ALA L 517
VAL L 502
TRP L 515
 None
 0.85A 2izqA-3uscL:
undetectable
2izqB-3uscL:
undetectable		 2izqA-3uscL:
5.26
2izqB-3uscL:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ALA L 414
THR L 532
GLY L 546
GLN L   8
PRO L 401
 None
FCO  L 601 (-3.7A)
None
None
None
 1.28A 2ve3B-3uscL:
0.8		 2ve3B-3uscL:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 LEU L 453
ILE L 276
ILE L 452
GLY L 283
 None
 0.86A 3bufA-3uscL:
undetectable		 3bufA-3uscL:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L   3
GLU L 391
HIS L 351
 None
LI  L 604 ( 4.3A)
None
 0.81A 3g1uB-3uscL:
undetectable		 3g1uB-3uscL:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ASP L 211
ARG L 214
ARG L 169
 None
 0.59A 3k37A-3uscL:
undetectable		 3k37A-3uscL:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 TRP L 515
ALA L 517
VAL L 502
 None
 1.01A 3l8lA-3uscL:
undetectable
3l8lB-3uscL:
undetectable		 3l8lA-3uscL:
5.26
3l8lB-3uscL:
2.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 GLN L   4
THR L   3
GLU L 391
HIS L 351
 None
None
LI  L 604 ( 4.3A)
None
 1.14A 3n58A-3uscL:
undetectable		 3n58A-3uscL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 GLN L   4
THR L   3
GLU L 391
HIS L 351
 None
None
LI  L 604 ( 4.3A)
None
 1.15A 3n58C-3uscL:
undetectable		 3n58C-3uscL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 GLN L   4
THR L   3
GLU L 391
HIS L 351
 None
None
LI  L 604 ( 4.3A)
None
 1.14A 3n58D-3uscL:
undetectable		 3n58D-3uscL:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 LEU L 114
THR L 532
THR L 533
ILE L 398
ILE L  75
 None
FCO  L 601 (-3.7A)
None
None
None
 1.15A 3sp9A-3uscL:
undetectable		 3sp9A-3uscL:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 LEU L 114
THR L 532
THR L 533
ILE L 398
VAL L  78
 None
FCO  L 601 (-3.7A)
None
None
3NI  L 602 ( 4.8A)
 1.20A 3sp9A-3uscL:
undetectable		 3sp9A-3uscL:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 GLY L 546
PRO L 538
TYR L 395
GLY L  50
 None
 0.90A 4fjpA-3uscL:
undetectable		 4fjpA-3uscL:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 THR L 533
PRO L 531
THR L 532
 None
FCO  L 601 (-3.5A)
FCO  L 601 (-3.7A)
 0.78A 4hivD-3uscL:
undetectable		 4hivD-3uscL:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 SER L 580
LEU L 577
PRO L 538
ILE L 398
ARG L 402
 None
 1.42A 4kmuC-3uscL:
0.8		 4kmuC-3uscL:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 THR L 505
THR L 113
HIS L 220
LEU L  85
 None
 1.10A 4pgfA-3uscL:
undetectable		 4pgfA-3uscL:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qvlV-3uscL:
undetectable
4qvlb-3uscL:
undetectable		 4qvlV-3uscL:
17.26
4qvlb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qvlH-3uscL:
undetectable
4qvlN-3uscL:
undetectable		 4qvlH-3uscL:
17.26
4qvlN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qvmV-3uscL:
undetectable
4qvmb-3uscL:
undetectable		 4qvmV-3uscL:
17.26
4qvmb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qvmH-3uscL:
undetectable
4qvmN-3uscL:
undetectable		 4qvmH-3uscL:
17.26
4qvmN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.32A 4qvpV-3uscL:
undetectable
4qvpb-3uscL:
undetectable		 4qvpV-3uscL:
17.26
4qvpb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.33A 4qvpH-3uscL:
undetectable
4qvpN-3uscL:
undetectable		 4qvpH-3uscL:
17.26
4qvpN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.30A 4qvqV-3uscL:
undetectable
4qvqb-3uscL:
undetectable		 4qvqV-3uscL:
17.26
4qvqb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qvqH-3uscL:
undetectable
4qvqN-3uscL:
undetectable		 4qvqH-3uscL:
17.26
4qvqN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.32A 4qvwV-3uscL:
undetectable
4qvwb-3uscL:
undetectable		 4qvwV-3uscL:
17.26
4qvwb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.32A 4qvwH-3uscL:
undetectable
4qvwN-3uscL:
undetectable		 4qvwH-3uscL:
17.26
4qvwN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qw0V-3uscL:
undetectable
4qw0b-3uscL:
undetectable		 4qw0V-3uscL:
17.26
4qw0b-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.30A 4qw0H-3uscL:
undetectable
4qw0N-3uscL:
undetectable		 4qw0H-3uscL:
17.26
4qw0N-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.32A 4qw1H-3uscL:
undetectable
4qw1N-3uscL:
undetectable		 4qw1H-3uscL:
17.26
4qw1N-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qw3V-3uscL:
undetectable
4qw3b-3uscL:
undetectable		 4qw3V-3uscL:
17.26
4qw3b-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.31A 4qw3H-3uscL:
undetectable
4qw3N-3uscL:
undetectable		 4qw3H-3uscL:
17.26
4qw3N-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 LEU L 417
VAL L 428
ASP L 432
 None
 0.64A 4y8wC-3uscL:
1.0		 4y8wC-3uscL:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ASN L 375
PRO L 376
SER L 396
TRP L 397
 None
 1.30A 5amiB-3uscL:
undetectable		 5amiB-3uscL:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.28A 5bxnV-3uscL:
undetectable
5bxnb-3uscL:
undetectable		 5bxnV-3uscL:
16.76
5bxnb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.30A 5bxnH-3uscL:
undetectable
5bxnN-3uscL:
undetectable		 5bxnH-3uscL:
16.76
5bxnN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.32A 5cz7H-3uscL:
undetectable
5cz7N-3uscL:
undetectable		 5cz7H-3uscL:
17.26
5cz7N-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.30A 5d0xV-3uscL:
undetectable
5d0xb-3uscL:
undetectable		 5d0xV-3uscL:
17.26
5d0xb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.30A 5d0xH-3uscL:
undetectable
5d0xN-3uscL:
undetectable		 5d0xH-3uscL:
17.26
5d0xN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 VAL L 502
GLY L 501
ARG L 500
VAL L 340
 None
 1.45A 5d4nA-3uscL:
undetectable
5d4nB-3uscL:
undetectable		 5d4nA-3uscL:
11.13
5d4nB-3uscL:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.28A 5l5zV-3uscL:
undetectable
5l5zb-3uscL:
undetectable		 5l5zV-3uscL:
17.26
5l5zb-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.28A 5l5zH-3uscL:
undetectable
5l5zN-3uscL:
undetectable		 5l5zH-3uscL:
17.26
5l5zN-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.29A 5l66V-3uscL:
undetectable
5l66b-3uscL:
undetectable		 5l66V-3uscL:
17.26
5l66b-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 HIS L 582
THR L 532
THR L 533
GLY L  29
ALA L 578
 MG  L 603 (-3.5A)
FCO  L 601 (-3.7A)
None
None
None
 1.28A 5l66H-3uscL:
undetectable
5l66N-3uscL:
undetectable		 5l66H-3uscL:
17.26
5l66N-3uscL:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 HIS L 351
GLU L 549
ASN L  45
 None
 1.01A 5wbvA-3uscL:
undetectable		 5wbvA-3uscL:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 HIS L 351
GLU L 549
ASN L  45
 None
 1.01A 5wbvB-3uscL:
undetectable		 5wbvB-3uscL:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 SER L  48
ALA L 352
SER L 396
ALA L 400
 None
 1.03A 6bocA-3uscL:
undetectable
6bocB-3uscL:
undetectable
6bocC-3uscL:
undetectable
6bocD-3uscL:
undetectable		 6bocA-3uscL:
3.68
6bocB-3uscL:
3.68
6bocC-3uscL:
3.68
6bocD-3uscL:
3.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3usc HYDROGENASE-1 LARGE
CHAIN
(Escherichia
coli) 		4 / 6 PHE L 212
ILE L 271
ASN L 272
ASP L 269
 None
 1.39A 6dhbA-3uscL:
undetectable		 6dhbA-3uscL:
11.27