SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3usz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 4 ARG A 140
ALA A 144
ALA A 389
GLU A 391
 None
 1.03A 1e7bB-3uszA:
undetectable		 1e7bB-3uszA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 6 ALA A 120
TRP A 106
LEU A 380
TRP A  81
 None
 1.20A 1gahA-3uszA:
undetectable		 1gahA-3uszA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 GLY A 130
ARG A 140
LEU A 388
GLU A 391
ALA A 392
 None
 1.01A 1mjqC-3uszA:
undetectable
1mjqD-3uszA:
undetectable		 1mjqC-3uszA:
8.46
1mjqD-3uszA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 GLY A 130
ARG A 140
LEU A 388
GLU A 391
ALA A 392
 None
 1.02A 1mjqI-3uszA:
undetectable
1mjqJ-3uszA:
undetectable		 1mjqI-3uszA:
8.46
1mjqJ-3uszA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 VAL A 149
ALA A 150
HIS A 376
 None
 0.66A 1q23G-3uszA:
undetectable		 1q23G-3uszA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ILE A  42
ASP A 317
PHE A 353
 None
 0.64A 1uwjB-3uszA:
undetectable		 1uwjB-3uszA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 THR A 212
ALA A 211
ALA A 159
VAL A 162
ALA A 249
 None
 1.00A 2f16K-3uszA:
undetectable
2f16L-3uszA:
undetectable		 2f16K-3uszA:
14.27
2f16L-3uszA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 THR A 212
ALA A 211
ALA A 159
VAL A 162
ALA A 249
 None
 0.99A 2f16Y-3uszA:
undetectable
2f16Z-3uszA:
undetectable		 2f16Y-3uszA:
14.27
2f16Z-3uszA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 THR A 571
ALA A 545
ASN A 402
PHE A 575
 None
 0.99A 2hzqA-3uszA:
undetectable		 2hzqA-3uszA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ALA A 213
VAL A 192
ALA A 249
TYR A 246
LEU A 280
 None
 1.21A 2japA-3uszA:
2.5		 2japA-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ALA A 213
VAL A 192
ALA A 249
TYR A 246
LEU A 280
 None
 1.20A 2japB-3uszA:
undetectable		 2japB-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ALA A 213
VAL A 192
ALA A 249
TYR A 246
LEU A 280
 None
 1.22A 2japC-3uszA:
2.1		 2japC-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ALA A 213
VAL A 192
ALA A 249
TYR A 246
LEU A 280
 None
 1.20A 2japD-3uszA:
undetectable		 2japD-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 11 GLY A 206
ILE A 195
ALA A 159
VAL A 149
ILE A 154
 None
 1.02A 2nnhA-3uszA:
undetectable		 2nnhA-3uszA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 127
SER A 580
ARG A 133
ILE A 138
 None
 1.24A 2qb4A-3uszA:
undetectable		 2qb4A-3uszA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.82A 2tsrA-3uszA:
undetectable		 2tsrA-3uszA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 9 THR A 212
PHE A 247
LEU A 280
VAL A 279
LEU A 284
 None
 1.09A 2zb8A-3uszA:
3.1		 2zb8A-3uszA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ASN A 566
ASP A 574
GLN A 612
 None
 0.69A 3eeyC-3uszA:
2.6		 3eeyC-3uszA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ASN A 566
ASP A 574
GLN A 612
 None
 0.67A 3eeyD-3uszA:
undetectable		 3eeyD-3uszA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ASN A 566
ASP A 574
GLN A 612
 None
 0.69A 3eeyE-3uszA:
undetectable		 3eeyE-3uszA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 TRP A 379
GLY A 142
GLY A 194
THR A 193
ASN A 208
 None
 1.43A 3fw1A-3uszA:
5.2		 3fw1A-3uszA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 4 GLN A  43
PRO A  44
VAL A 321
GLU A 323
 None
 1.26A 3huoA-3uszA:
undetectable		 3huoA-3uszA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ARG A 268
ASP A 497
GLN A 437
 None
 0.95A 3lcvB-3uszA:
undetectable		 3lcvB-3uszA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ILE A 127
GLY A 130
GLY A 128
SER A 396
GLY A 577
 None
 1.00A 3uboA-3uszA:
3.9		 3uboA-3uszA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 PHE A 446
SER A 435
SER A 433
 None
 0.92A 3ufgB-3uszA:
undetectable		 3ufgB-3uszA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 SER A 554
GLY A 553
GLN A 428
 None
 0.55A 3v4tH-3uszA:
undetectable		 3v4tH-3uszA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 9 VAL A 398
LEU A 400
PRO A 533
SER A 530
LEU A 579
 None
 1.42A 3w1wA-3uszA:
2.1
3w1wB-3uszA:
1.9		 3w1wA-3uszA:
20.00
3w1wB-3uszA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 9 VAL A 398
SER A 530
LEU A 400
PRO A 533
LEU A 579
 None
 1.30A 3w1wA-3uszA:
2.1
3w1wB-3uszA:
1.9		 3w1wA-3uszA:
20.00
3w1wB-3uszA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.98A 3w9tA-3uszA:
undetectable		 3w9tA-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.97A 3w9tB-3uszA:
undetectable		 3w9tB-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.98A 3w9tC-3uszA:
undetectable		 3w9tC-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.98A 3w9tD-3uszA:
undetectable		 3w9tD-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.97A 3w9tE-3uszA:
undetectable		 3w9tE-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.97A 3w9tF-3uszA:
undetectable		 3w9tF-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 ASP A 317
VAL A 316
GLY A 315
ASP A 348
 None
 0.97A 3w9tG-3uszA:
undetectable		 3w9tG-3uszA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 PHE A 590
PRO A 601
GLN A 589
LEU A 592
LEU A 594
 None
 1.37A 4ac0A-3uszA:
undetectable		 4ac0A-3uszA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1491_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 4 GLY A  47
TRP A 106
GLU A  45
THR A  68
 None
 1.25A 4at0A-3uszA:
0.0		 4at0A-3uszA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 PHE A 353
ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 1.35A 4eb4D-3uszA:
undetectable		 4eb4D-3uszA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 PHE A 575
TYR A 611
VAL A 547
LEU A 397
ILE A 452
 None
 0.99A 4g1bA-3uszA:
undetectable		 4g1bA-3uszA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 127
THR A 173
VAL A 393
SER A 530
 None
 1.38A 4iarA-3uszA:
undetectable		 4iarA-3uszA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.66A 4iqqB-3uszA:
undetectable		 4iqqB-3uszA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.68A 4iqqC-3uszA:
undetectable		 4iqqC-3uszA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ILE A 100
ALA A  30
ILE A 358
LEU A 354
ILE A 102
 None
 0.95A 4kjjA-3uszA:
undetectable		 4kjjA-3uszA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ASP A  86
TRP A 360
SER A 374
 None
 1.05A 4lrhB-3uszA:
undetectable		 4lrhB-3uszA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ASP A  86
TRP A 360
SER A 374
 None
 1.02A 4lrhF-3uszA:
undetectable		 4lrhF-3uszA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFL_B_GCSB502_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 6 GLN A  40
MET A  32
ALA A  92
PHE A 363
 None
 1.47A 4mflA-3uszA:
0.0		 4mflA-3uszA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MFQ_B_GCSB503_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24
TEICOPLANIN
PSEUDOAGLYCONE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 6 GLN A  40
MET A  32
ALA A  92
PHE A 363
 None
 1.49A 4mfqA-3uszA:
0.0		 4mfqA-3uszA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 VAL A 164
ALA A 163
GLY A 237
GLY A 218
ASP A 180
 None
 1.15A 4mm8A-3uszA:
undetectable		 4mm8A-3uszA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 11 VAL A 164
ALA A 163
GLY A 237
GLY A 218
ASP A 180
 None
 1.08A 4mm9A-3uszA:
undetectable		 4mm9A-3uszA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 PHE A 573
ALA A 392
ALA A 131
GLY A 128
LEU A 129
 None
 1.07A 4oaeA-3uszA:
undetectable		 4oaeA-3uszA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 12 ILE A 100
ALA A  30
ILE A 358
LEU A 354
ILE A 102
 None
 0.90A 4pssA-3uszA:
undetectable		 4pssA-3uszA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 6 ALA A 356
ILE A 250
ILE A 210
VAL A 192
 None
 0.81A 4r21A-3uszA:
undetectable		 4r21A-3uszA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 11 LEU A 514
GLY A 487
LEU A 529
LEU A 513
ALA A 418
 None
 0.88A 4wnuA-3uszA:
undetectable		 4wnuA-3uszA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 LYS A 585
TYR A 586
SER A 621
LEU A 620
 None
 0.86A 5bphB-3uszA:
3.9		 5bphB-3uszA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.83A 5h3aA-3uszA:
undetectable		 5h3aA-3uszA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.86A 5h3aB-3uszA:
undetectable		 5h3aB-3uszA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 LYS A 281
GLN A 310
ASN A 313
 None
 0.84A 5l2tA-3uszA:
undetectable		 5l2tA-3uszA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 11 ALA A 213
THR A 212
ALA A 211
VAL A 162
ALA A 249
 None
 0.96A 5lf7K-3uszA:
undetectable
5lf7L-3uszA:
undetectable		 5lf7K-3uszA:
13.27
5lf7L-3uszA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 11 ALA A 213
THR A 212
ALA A 211
VAL A 162
ALA A 249
 None
 0.96A 5lf7Y-3uszA:
undetectable
5lf7Z-3uszA:
undetectable		 5lf7Y-3uszA:
13.27
5lf7Z-3uszA:
14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		9 / 12 LEU A  63
ASP A 109
PHE A 158
ARG A 172
HIS A 215
MET A 258
MET A 320
TRP A 432
GLU A 493
 None
 1.00A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		6 / 12 LEU A  63
ASP A 109
PHE A 158
LYS A 214
HIS A 215
MET A 258
 None
 1.03A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M6G_A_SORA711_0
(BETA-GLUCOSIDASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		7 / 12 LEU A  63
GLY A  65
PHE A 158
ARG A 172
HIS A 215
MET A 258
MET A 320
 None
 0.79A 5m6gA-3uszA:
36.1		 5m6gA-3uszA:
37.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 8 HIS A 125
HIS A 112
GLY A 113
SER A 115
 None
 0.79A 5m8rC-3uszA:
undetectable		 5m8rC-3uszA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.72A 5nooA-3uszA:
undetectable		 5nooA-3uszA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.64A 5nooB-3uszA:
undetectable		 5nooB-3uszA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 5 VAL A 525
ASP A 544
PRO A 523
ALA A 545
 None
 1.14A 5otrA-3uszA:
undetectable		 5otrA-3uszA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 7 ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 0.89A 5x5qC-3uszA:
undetectable		 5x5qC-3uszA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 PHE A 353
ILE A 210
ASP A 287
GLY A 288
PHE A 289
 None
 1.41A 5x66D-3uszA:
undetectable		 5x66D-3uszA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 9 HIS A 114
LEU A 137
ALA A 392
VAL A 393
SER A 396
 None
 1.36A 6c2mB-3uszA:
undetectable		 6c2mB-3uszA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		5 / 10 GLY A 221
ASP A 497
ASP A 227
GLU A 488
GLU A 175
 None
 1.39A 6cgdA-3uszA:
0.0		 6cgdA-3uszA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		4 / 6 SER A  61
GLN A  40
GLU A 155
THR A 108
 None
 1.50A 6djzA-3uszA:
undetectable		 6djzA-3uszA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 ALA A 327
PHE A 325
GLN A  53
 None
 0.75A 6eceA-3uszA:
undetectable		 6eceA-3uszA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3usz EXO-1,3/1,4-BETA-GLU
CANASE
(Pseudoalteromona
s
sp.
BB1) 		3 / 3 LEU A 602
ASN A 403
LEU A 609
 None
 0.54A 6exiD-3uszA:
undetectable		 6exiD-3uszA:
6.51