SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 ASP A 297
PHE A 167
GLN A 464
GLU A 465
ILE A 468
 None
 1.17A 1fkbA-3utoA:
undetectable		 1fkbA-3utoA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 SER A 378
GLY A 379
ARG A 427
 None
 0.68A 1t9wA-3utoA:
2.8		 1t9wA-3utoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 ALA A 505
PHE A 482
ARG A 553
ASN A 556
 None
 1.11A 1t9wA-3utoA:
2.8		 1t9wA-3utoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 ASP A 440
GLU A   8
TYR A  41
 None
 0.73A 1wsvA-3utoA:
1.0		 1wsvA-3utoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 VAL A 565
TYR A 550
GLY A 536
ASP A 534
 None
None
PEG  A 572 ( 4.4A)
None
 0.93A 2y05A-3utoA:
undetectable
2y05B-3utoA:
undetectable		 2y05A-3utoA:
20.04
2y05B-3utoA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 10 LEU A 162
VAL A 170
LYS A 185
VAL A 214
PHE A 232
 None
 0.96A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 10 LEU A 162
VAL A 170
VAL A 214
PHE A 232
ASP A 297
 None
 0.85A 3cs9A-3utoA:
20.8		 3cs9A-3utoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 TYR A 550
GLY A 548
LEU A 520
ARG A 518
 None
 0.81A 3elzA-3utoA:
undetectable		 3elzA-3utoA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 ARG A  11
PHE A  12
PRO A  13
 None
 0.88A 3zoaB-3utoA:
undetectable		 3zoaB-3utoA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 8 ILE A 296
ASP A 297
ILE A 452
GLY A 163
 None
 0.82A 4acaC-3utoA:
undetectable		 4acaC-3utoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 8 ILE A 296
ASP A 297
ILE A 452
GLY A 163
 None
 0.80A 4acbC-3utoA:
undetectable		 4acbC-3utoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 ASP A 194
PRO A  96
HIS A 461
SER A 193
 None
 1.27A 4k7gB-3utoA:
undetectable		 4k7gB-3utoA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		7 / 12 LEU A 162
GLY A 163
GLY A 165
GLY A 168
VAL A 170
ALA A 183
LYS A 185
 None
 0.44A 4otiA-3utoA:
20.7		 4otiA-3utoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 GLU A 477
THR A 301
HIS A 275
LEU A 265
 FLC  A 573 ( 4.7A)
None
None
None
 1.02A 4pfjA-3utoA:
undetectable		 4pfjA-3utoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 VAL A 255
TRP A 410
PHE A 387
HIS A 408
 None
 1.40A 5ad9A-3utoA:
undetectable
5ad9B-3utoA:
undetectable		 5ad9A-3utoA:
20.97
5ad9B-3utoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 TYR A 140
SER A 234
ILE A 452
HIS A 217
VAL A 170
 None
 1.15A 5dpdA-3utoA:
undetectable		 5dpdA-3utoA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 ASN A 364
GLY A 340
SER A 338
GLY A 354
SER A 351
 None
 1.11A 5hikA-3utoA:
undetectable		 5hikA-3utoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 5 ILE A 402
CYH A 262
LEU A 278
HIS A 269
 None
 1.31A 5hrqC-3utoA:
undetectable
5hrqD-3utoA:
undetectable
5hrqL-3utoA:
undetectable		 5hrqC-3utoA:
3.18
5hrqD-3utoA:
3.22
5hrqL-3utoA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 GLY A 163
GLY A 165
GLY A 168
VAL A 170
 None
 0.26A 5izjB-3utoA:
25.7		 5izjB-3utoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 GLY A 163
GLY A 165
VAL A 170
LYS A 185
 None
 0.41A 5izjA-3utoA:
25.6		 5izjA-3utoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 7 GLY A 163
GLY A 165
VAL A 170
LYS A 185
 None
 0.36A 5j5xA-3utoA:
24.9		 5j5xA-3utoA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		5 / 12 VAL A 310
ASP A 470
ASP A 277
PRO A 329
GLY A 327
 None
 1.29A 5syeB-3utoA:
undetectable		 5syeB-3utoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		4 / 8 PHE A 239
ILE A 435
THR A 316
PHE A 319
 None
 0.83A 5x23A-3utoA:
undetectable		 5x23A-3utoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 3uto TWITCHIN
(Caenorhabditis
elegans) 		3 / 3 PHE A 387
ASP A 386
LYS A 390
 None
 0.87A 6awtD-3utoA:
undetectable		 6awtD-3utoA:
15.68