SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 8 ASP A 242
ASP A 213
TYR A 323
THR A 259
 BDP  A 331 (-2.7A)
None
None
None
 1.43A 1ceaA-3uugA:
undetectable
1ceaB-3uugA:
undetectable		 1ceaA-3uugA:
10.89
1ceaB-3uugA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 4 GLU A 244
TYR A 212
PRO A 211
ASP A 213
 None
BDP  A 331 (-3.2A)
None
None
 1.44A 1i7zD-3uugA:
0.0		 1i7zD-3uugA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 6 GLY A 112
GLN A 110
VAL A 156
ALA A 116
 None
 0.96A 1p6kA-3uugA:
undetectable		 1p6kA-3uugA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		3 / 3 MET A 175
ASN A 108
GLN A 241
 None
None
BDP  A 331 ( 4.1A)
 1.04A 1xoqB-3uugA:
undetectable		 1xoqB-3uugA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 SER A 247
PRO A 211
LEU A 223
MET A 192
GLU A 135
 None
 1.37A 2c7vC-3uugA:
7.6		 2c7vC-3uugA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 8 GLU A 255
ILE A 220
ILE A 217
LYS A 224
 None
 0.91A 2j9dJ-3uugA:
undetectable
2j9dK-3uugA:
undetectable
2j9dL-3uugA:
undetectable		 2j9dJ-3uugA:
18.04
2j9dK-3uugA:
18.04
2j9dL-3uugA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 SER A 247
PRO A 211
LEU A 223
MET A 192
GLU A 135
 None
 1.21A 3bmcC-3uugA:
7.8		 3bmcC-3uugA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 9 TYR A 150
GLY A 112
ALA A 116
THR A 120
ILE A 134
 None
 1.29A 3jusB-3uugA:
undetectable		 3jusB-3uugA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 GLY A 139
GLY A 179
LEU A 215
LEU A 181
ALA A 146
 None
 0.96A 3kkzA-3uugA:
2.4		 3kkzA-3uugA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 TYR A 150
GLY A 112
ALA A 116
THR A 120
ILE A 134
 None
 1.29A 3ld6A-3uugA:
undetectable		 3ld6A-3uugA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 ASP A 143
ASP A  91
ARG A  17
TRP A  18
ASP A 242
 BDP  A 331 (-2.8A)
BDP  A 331 (-3.0A)
BDP  A 331 (-4.0A)
BDP  A 331 ( 4.9A)
BDP  A 331 (-2.7A)
 1.17A 3phaA-3uugA:
2.7		 3phaA-3uugA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 6 ILE A  88
ILE A  19
TRP A  18
MET A  10
 None
None
BDP  A 331 ( 4.9A)
None
 1.25A 3weoA-3uugA:
undetectable		 3weoA-3uugA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 10 LEU A 166
GLY A 164
TYR A 160
ALA A 116
ILE A 134
 None
 1.17A 4xj7C-3uugA:
3.0
4xj7D-3uugA:
3.1		 4xj7C-3uugA:
23.28
4xj7D-3uugA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 GLY A 139
TYR A 212
SER A 210
ASP A 143
ALA A 146
 None
BDP  A 331 (-3.2A)
None
BDP  A 331 (-2.8A)
None
 1.19A 4ymgB-3uugA:
3.5		 4ymgB-3uugA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 ASP A 213
TYR A 212
SER A 216
ALA A 186
ALA A 188
 None
BDP  A 331 (-3.2A)
None
None
None
 1.29A 5cxvA-3uugA:
undetectable		 5cxvA-3uugA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 8 THR A 310
GLN A 256
VAL A 111
GLY A 112
 None
 1.02A 5nzyA-3uugA:
undetectable		 5nzyA-3uugA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O45_B_CCSB13_0
(PHE-MEA-9KK-SAR-ASP-
VAL-MEA-TYR-SAR-TRP-
TYR-LEU-CCS-GLY-NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 9 TYR A 200
GLU A 135
ASN A 133
TYR A 199
GLY A 171
 None
 1.16A 5o45A-3uugA:
0.0
5o45B-3uugA:
undetectable		 5o45A-3uugA:
17.36
5o45B-3uugA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		4 / 6 PHE A 137
LEU A 209
SER A 216
GLY A 240
 None
 1.02A 5o4yF-3uugA:
undetectable		 5o4yF-3uugA:
3.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 LEU A 209
GLY A 240
ILE A 134
VAL A 205
ILE A 119
 None
 0.80A 6emuB-3uugA:
2.1		 6emuB-3uugA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 LEU A 209
GLY A 240
ILE A 134
VAL A 205
ILE A 119
 None
 0.80A 6emuC-3uugA:
1.9		 6emuC-3uugA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3uug MULTIPLE
SUGAR-BINDING
PERIPLASMIC RECEPTOR
CHVE
(Agrobacterium
fabrum) 		5 / 12 GLY A 240
GLN A 241
TYR A 323
LEU A 318
ILE A 251
 None
BDP  A 331 ( 4.1A)
None
None
None
 1.40A 6md4A-3uugA:
undetectable		 6md4A-3uugA:
11.82