SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uuw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		3 / 3 TRP A 174
LEU A 173
LYS A 292
 GOL  A 310 ( 4.2A)
None
None
 1.31A 1yajK-3uuwA:
undetectable		 1yajK-3uuwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 12 GLY A 287
VAL A  92
ILE A  80
GLY A 103
PRO A  95
 None
 0.90A 2avsB-3uuwA:
undetectable		 2avsB-3uuwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 12 SER A 270
PHE A 266
ASP A  93
TYR A  19
GLU A 222
 None
 1.40A 2c7vB-3uuwA:
7.7		 2c7vB-3uuwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 12 LEU A  69
VAL A 119
GLY A 103
VAL A  90
VAL A  92
 None
 0.57A 2ieoB-3uuwA:
undetectable		 2ieoB-3uuwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 11 LEU A  69
VAL A 119
GLY A 103
VAL A  90
VAL A  92
 None
 0.70A 2nnpB-3uuwA:
undetectable		 2nnpB-3uuwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		3 / 3 ARG A 234
GLU A 242
SER A 217
 None
 0.64A 2xctD-3uuwA:
undetectable		 2xctD-3uuwA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		4 / 6 SER A 270
PHE A 266
ASP A  93
TYR A  19
 None
 1.05A 3jqaA-3uuwA:
undetectable		 3jqaA-3uuwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		4 / 6 SER A 270
PHE A 266
ASP A  93
TYR A  19
 None
 1.06A 3jqaB-3uuwA:
7.9		 3jqaB-3uuwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		4 / 6 SER A 270
PHE A 266
ASP A  93
TYR A  19
 None
 1.07A 3jqaC-3uuwA:
undetectable		 3jqaC-3uuwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		4 / 6 SER A 270
PHE A 266
ASP A  93
TYR A  19
 None
 1.04A 3jqaD-3uuwA:
9.2		 3jqaD-3uuwA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 10 LEU A  69
VAL A 119
GLY A 103
VAL A  90
VAL A  92
 None
 0.83A 3nu9B-3uuwA:
undetectable		 3nu9B-3uuwA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		3 / 3 ARG A 123
PRO A  95
PHE A 121
 None
 0.88A 3thrC-3uuwA:
undetectable		 3thrC-3uuwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		3 / 3 LEU A 261
ILE A  22
TYR A  91
 None
 0.53A 5uunB-3uuwA:
undetectable		 5uunB-3uuwA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3uuw PUTATIVE
OXIDOREDUCTASE WITH
NAD(P)-BINDING
ROSSMANN-FOLD DOMAIN
(Clostridioides
difficile) 		5 / 12 LEU A  69
VAL A 119
GLY A 103
VAL A  90
VAL A  92
 None
 0.80A 6dh0A-3uuwA:
undetectable		 6dh0A-3uuwA:
14.93