SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 8 HIS A 195
GLY A 150
GLY A 153
LEU A 192
 None
None
PG4  A 305 ( 4.2A)
None
 0.74A 1aegA-3uveA:
undetectable		 1aegA-3uveA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 9 GLY A  14
ASP A  38
ILE A  39
ALA A 108
ILE A 131
 NAD  A 300 (-3.4A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.8A)
 0.86A 1cetA-3uveA:
8.9		 1cetA-3uveA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 6 SER A 161
VAL A 162
GLY A 163
TYR A 174
 NAD  A 300 (-3.4A)
None
None
NAD  A 300 (-4.7A)
 0.64A 1fduD-3uveA:
26.2		 1fduD-3uveA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 6 VAL A  12
VAL A   5
ILE A 157
ARG A  21
 None
 1.11A 1iepA-3uveA:
undetectable		 1iepA-3uveA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 VAL A  79
LEU A 158
ALA A 106
ALA A 142
VAL A 144
 None
 1.16A 1sa1A-3uveA:
6.1
1sa1B-3uveA:
6.4		 1sa1A-3uveA:
20.40
1sa1B-3uveA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		6 / 11 GLY A  14
ALA A  16
ASP A  38
ASP A  80
VAL A  81
ALA A 108
 NAD  A 300 (-3.4A)
NAD  A 300 ( 3.8A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
 0.23A 1uayA-3uveA:
29.2		 1uayA-3uveA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		6 / 10 GLY A  14
ALA A  16
ASP A  38
ASP A  80
VAL A  81
ALA A 108
 NAD  A 300 (-3.4A)
NAD  A 300 ( 3.8A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 (-3.6A)
 0.26A 1uayB-3uveA:
29.6		 1uayB-3uveA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 GLY A 183
VAL A 140
ILE A 156
GLY A 189
VAL A 190
 None
 0.87A 2avsB-3uveA:
undetectable		 2avsB-3uveA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 GLY A  14
ASP A  38
ASP A  80
ASN A 107
ALA A 108
 NAD  A 300 (-3.4A)
NAD  A 300 (-2.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.3A)
NAD  A 300 (-3.6A)
 0.95A 2bm9E-3uveA:
4.6		 2bm9E-3uveA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 GLY A  14
ILE A  39
ASP A  80
VAL A  81
ARG A  82
 NAD  A 300 (-3.4A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
NAD  A 300 ( 4.9A)
 0.87A 2qe6A-3uveA:
undetectable		 2qe6A-3uveA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 ALA A  16
ILE A  39
ASP A  80
VAL A  81
VAL A 105
 NAD  A 300 ( 3.8A)
NAD  A 300 (-3.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
None
 1.03A 2qe6B-3uveA:
5.6		 2qe6B-3uveA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 VAL A  67
SER A 254
ASN A 107
VAL A 105
ALA A  10
 None
None
NAD  A 300 (-3.3A)
None
None
 1.22A 2x2iA-3uveA:
undetectable		 2x2iA-3uveA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 VAL A  67
SER A 254
ASN A 107
VAL A 105
ALA A  10
 None
None
NAD  A 300 (-3.3A)
None
None
 1.23A 2x2iC-3uveA:
undetectable		 2x2iC-3uveA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 10 ASP A  38
ILE A  39
ALA A  16
ASP A  80
VAL A  81
 NAD  A 300 (-2.8A)
NAD  A 300 (-3.8A)
NAD  A 300 ( 3.8A)
NAD  A 300 (-3.4A)
NAD  A 300 (-3.6A)
 0.79A 3ay0A-3uveA:
6.4		 3ay0A-3uveA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 6 ASP A  80
LEU A  87
ASP A  38
LEU A  60
 NAD  A 300 (-3.4A)
None
NAD  A 300 (-2.8A)
None
 1.24A 3bj8C-3uveA:
undetectable
3bj8D-3uveA:
undetectable		 3bj8C-3uveA:
20.57
3bj8D-3uveA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		3 / 3 PHE A 221
CYH A 237
PHE A 240
 None
 0.78A 3cr5X-3uveA:
undetectable		 3cr5X-3uveA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 6 VAL A 105
ILE A 253
ILE A 157
LEU A 158
 None
 0.76A 3hegA-3uveA:
undetectable		 3hegA-3uveA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 7 PHE A  11
ALA A 106
THR A  13
LEU A  87
 None
 0.84A 3t3sC-3uveA:
undetectable		 3t3sC-3uveA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		6 / 12 GLY A 111
ILE A  39
VAL A 136
VAL A 207
ILE A 253
THR A 209
 None
NAD  A 300 (-3.8A)
None
NAD  A 300 (-4.1A)
None
NAD  A 300 (-2.7A)
 1.10A 4q5mA-3uveA:
undetectable		 4q5mA-3uveA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 12 ILE A  34
ALA A  15
THR A 139
VAL A 144
LEU A 158
 None
 1.23A 4qynA-3uveA:
undetectable		 4qynA-3uveA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		5 / 10 HIS A 203
LEU A 165
SER A 201
GLY A 183
VAL A 181
 None
 1.32A 4yb6A-3uveA:
undetectable
4yb6D-3uveA:
undetectable		 4yb6A-3uveA:
24.07
4yb6D-3uveA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3uve CARVEOL
DEHYDROGENASE
((+)-TRANS-CARVEOL
DEHYDROGENASE)
(Mycobacterium
avium) 		4 / 8 THR A 171
ASP A 130
VAL A 181
GLY A 180
 None
 0.84A 5nzyA-3uveA:
undetectable		 5nzyA-3uveA:
21.54