SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 LEU A 626
LEU A 554
PHE A 634
PHE A 656
ILE A 616
 None
 1.16A 1g5yC-3uvjA:
undetectable		 1g5yC-3uvjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		4 / 5 LEU A 506
PRO A 499
VAL A 502
ILE A 503
 None
 1.02A 2aoiB-3uvjA:
undetectable		 2aoiB-3uvjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 ASN A 605
GLU A 608
ARG A 574
ASP A 530
ILE A 487
 None
 1.33A 3jb3A-3uvjA:
undetectable		 3jb3A-3uvjA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 11 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.09A 5lg3A-3uvjA:
undetectable		 5lg3A-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.08A 5lg3E-3uvjA:
undetectable		 5lg3E-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.07A 5lg3F-3uvjA:
undetectable		 5lg3F-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.11A 5lg3G-3uvjA:
1.7		 5lg3G-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 10 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.09A 5lg3H-3uvjA:
undetectable		 5lg3H-3uvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uvj GUANYLATE CYCLASE
SOLUBLE SUBUNIT
ALPHA-3
(Homo
sapiens) 		5 / 12 ILE A 571
ILE A 487
PHE A 490
VAL A 563
ASN A 507
 None
 1.06A 5lg3J-3uvjA:
undetectable		 5lg3J-3uvjA:
20.51