SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 ALA A 314
VAL A 312
TRP A 305
EDO  A 471 (-3.3A)
None
EDO  A 471 (-3.9A)
0.88A 1bdwA-3uw2A:
undetectable
1bdwB-3uw2A:
undetectable
1bdwA-3uw2A:
2.95
1bdwB-3uw2A:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 LEU A 265
LEU A 291
VAL A 295
LEU A 273
ALA A 279
None
1.06A 1gseB-3uw2A:
undetectable
1gseB-3uw2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 GLY A 347
ARG A 172
GLU A 237
LEU A 354
PRO A 360
None
1.49A 1mjqG-3uw2A:
undetectable
1mjqH-3uw2A:
undetectable
1mjqG-3uw2A:
12.67
1mjqH-3uw2A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
0.99A 1pxxA-3uw2A:
undetectable
1pxxA-3uw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.00A 1pxxC-3uw2A:
undetectable
1pxxC-3uw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 7 THR A 107
VAL A 184
GLY A 183
ASP A 247
None
None
None
ZN  A 474 ( 2.5A)
0.95A 2a1mA-3uw2A:
undetectable
2a1mA-3uw2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A  83
GLY A 244
ASP A 243
ALA A 185
ALA A 189
None
None
ZN  A 474 ( 2.5A)
None
None
1.02A 2bm9F-3uw2A:
undetectable
2bm9F-3uw2A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 ALA A 279
ALA A 321
LEU A 316
LEU A 273
VAL A 272
None
1.24A 2bxeA-3uw2A:
undetectable
2bxeA-3uw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 7 TYR A  84
GLU A 326
HIS A 309
GLY A 308
None
1.12A 2ha4B-3uw2A:
undetectable
2ha4B-3uw2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 5 GLN A 264
PHE A 268
PHE A 333
GLY A 343
None
1.13A 2qmzA-3uw2A:
undetectable
2qmzB-3uw2A:
1.4
2qmzA-3uw2A:
19.50
2qmzB-3uw2A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 TYR A  84
GLU A 326
ASP A 408
None
0.60A 3bxoA-3uw2A:
undetectable
3bxoA-3uw2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 TYR A  84
GLU A 326
ASP A 408
None
0.71A 3bxoB-3uw2A:
undetectable
3bxoB-3uw2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 5 HIS A 330
HIS A 309
ASP A 247
ASP A 245
None
None
ZN  A 474 ( 2.5A)
ZN  A 474 (-2.6A)
1.14A 3c0zA-3uw2A:
undetectable
3c0zA-3uw2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 6 HIS A 330
HIS A 309
ASP A 247
ASP A 245
None
None
ZN  A 474 ( 2.5A)
ZN  A 474 (-2.6A)
1.15A 3c0zC-3uw2A:
undetectable
3c0zC-3uw2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A 123
GLU A  35
PHE A  32
GLN A 131
None
None
None
EDO  A 469 (-3.7A)
1.39A 3gclA-3uw2A:
undetectable
3gclA-3uw2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 4 GLY A 400
ASP A 448
GLY A 419
THR A 437
None
1.09A 3k4vC-3uw2A:
undetectable
3k4vC-3uw2A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 3ln1C-3uw2A:
undetectable
3ln1C-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 3nt1A-3uw2A:
undetectable
3nt1A-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.05A 3nt1B-3uw2A:
undetectable
3nt1B-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.02A 3pghA-3uw2A:
undetectable
3pghA-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.03A 3pghD-3uw2A:
undetectable
3pghD-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 ASP A 245
ASP A 247
HIS A 330
ALA A 185
PHE A 242
ZN  A 474 (-2.6A)
ZN  A 474 ( 2.5A)
None
None
None
1.42A 3r2jC-3uw2A:
undetectable
3r2jC-3uw2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.06A 4coxA-3uw2A:
undetectable
4coxA-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.06A 4coxB-3uw2A:
undetectable
4coxB-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.05A 4coxC-3uw2A:
undetectable
4coxC-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.05A 4coxD-3uw2A:
undetectable
4coxD-3uw2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 ASP A 247
ARG A 248
ASP A  11
ZN  A 474 ( 2.5A)
GOL  A 472 ( 4.0A)
None
0.88A 4fzvA-3uw2A:
undetectable
4fzvA-3uw2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
6 / 12 ASP A  63
VAL A  72
GLY A  29
SER A 148
GLY A  69
ASP A  74
EDO  A 467 (-3.8A)
None
None
None
None
None
1.26A 4mm8A-3uw2A:
undetectable
4mm8A-3uw2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  63
VAL A  72
GLY A  29
GLY A  69
ASP A  74
EDO  A 467 (-3.8A)
None
None
None
None
1.16A 4mmcA-3uw2A:
undetectable
4mmcA-3uw2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 ASP A  63
VAL A  72
GLY A  29
GLY A 149
ASP A  74
EDO  A 467 (-3.8A)
None
None
None
None
1.41A 4mmcA-3uw2A:
undetectable
4mmcA-3uw2A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.02A 4otyA-3uw2A:
undetectable
4otyA-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 4otyB-3uw2A:
undetectable
4otyB-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 VAL A  46
GLY A  64
ILE A 104
GLY A  33
ILE A 139
None
0.92A 4q5mA-3uw2A:
undetectable
4q5mA-3uw2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 ALA A 189
GLY A 347
ALA A 236
GLY A 239
PHE A 240
None
1.19A 4r29A-3uw2A:
undetectable
4r29A-3uw2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 ALA A 189
GLY A 347
ALA A 236
GLY A 239
PHE A 240
None
1.21A 4r29B-3uw2A:
undetectable
4r29B-3uw2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 ALA A 189
GLY A 347
ALA A 236
GLY A 239
PHE A 240
None
1.22A 4r29C-3uw2A:
undetectable
4r29C-3uw2A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.03A 4rrwA-3uw2A:
undetectable
4rrwA-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.01A 4rrwB-3uw2A:
undetectable
4rrwB-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 4rrwC-3uw2A:
undetectable
4rrwC-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 4rrwD-3uw2A:
undetectable
4rrwD-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.07A 4rrxA-3uw2A:
undetectable
4rrxA-3uw2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.11A 4rrxB-3uw2A:
undetectable
4rrxB-3uw2A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.03A 4rrzA-3uw2A:
undetectable
4rrzA-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.01A 4rrzB-3uw2A:
undetectable
4rrzB-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 4rrzC-3uw2A:
undetectable
4rrzC-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.04A 4rrzD-3uw2A:
undetectable
4rrzD-3uw2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 8 LEU A 392
ALA A 452
LEU A 432
LEU A 388
ALA A 456
None
0.95A 4z90A-3uw2A:
undetectable
4z90B-3uw2A:
undetectable
4z90C-3uw2A:
undetectable
4z90D-3uw2A:
undetectable
4z90E-3uw2A:
undetectable
4z90A-3uw2A:
21.63
4z90B-3uw2A:
21.63
4z90C-3uw2A:
21.63
4z90D-3uw2A:
21.63
4z90E-3uw2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.01A 5ikqA-3uw2A:
undetectable
5ikqA-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.00A 5ikqB-3uw2A:
undetectable
5ikqB-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
0.98A 5ikrA-3uw2A:
undetectable
5ikrA-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
0.97A 5ikrB-3uw2A:
undetectable
5ikrB-3uw2A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 ILE A 238
GLY A 250
PHE A 240
TYR A 260
ILE A 259
None
GOL  A 472 (-3.5A)
None
None
None
1.09A 5j7wD-3uw2A:
undetectable
5j7wD-3uw2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 TYR A 338
TRP A 337
VAL A  82
ALA A  86
LEU A  91
None
1.06A 5jvzA-3uw2A:
undetectable
5jvzA-3uw2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 7 ASP A 342
THR A 346
LEU A 344
VAL A  78
None
1.13A 5ov9A-3uw2A:
undetectable
5ov9A-3uw2A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
4 / 6 ARG A  51
GLY A  50
SER A 109
VAL A 184
None
EDO  A 466 (-3.9A)
PO4  A 465 ( 1.6A)
None
1.17A 5ysiA-3uw2A:
undetectable
5ysiA-3uw2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 ASP A 247
ARG A 248
ASP A  11
ZN  A 474 ( 2.5A)
GOL  A 472 ( 4.0A)
None
0.80A 5zvgA-3uw2A:
undetectable
5zvgA-3uw2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 ASP A 247
ARG A 248
ASP A  11
ZN  A 474 ( 2.5A)
GOL  A 472 ( 4.0A)
None
0.85A 5zvgB-3uw2A:
undetectable
5zvgB-3uw2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 10 LEU A  52
SER A  53
LEU A  20
GLY A 244
VAL A 106
None
1.02A 6eu9B-3uw2A:
undetectable
6eu9B-3uw2A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
3 / 3 ARG A 289
PHE A 418
GLY A 417
None
0.69A 6fgdA-3uw2A:
4.0
6fgdA-3uw2A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 250
GLY A 343
VAL A 331
ALA A 189
PHE A 268
GOL  A 472 (-3.5A)
None
None
None
None
1.04A 6nj9K-3uw2A:
undetectable
6nj9K-3uw2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN

(Burkholderia
thailandensis)
5 / 12 GLY A 250
GLY A 347
GLY A 343
VAL A 331
ALA A 189
GOL  A 472 (-3.5A)
None
None
None
None
0.78A 6nj9K-3uw2A:
undetectable
6nj9K-3uw2A:
21.06