SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
 1.01A 1d4sA-3uw3A:
undetectable		 1d4sA-3uw3A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 10 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.10A 1d4yA-3uw3A:
undetectable		 1d4yA-3uw3A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 THR A 156
GLU A 241
ASP A 232
 None
 0.78A 1nt2A-3uw3A:
3.5		 1nt2A-3uw3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ARG A 365
ARG A 364
ILE A  94
 EDO  A 374 (-3.9A)
EDO  A 374 (-4.3A)
None
 0.64A 1uobA-3uw3A:
undetectable		 1uobA-3uw3A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A   5
PHE A  46
ASP A  27
GLY A  24
PHE A  33
 None
 1.03A 1zz1B-3uw3A:
undetectable
1zz1C-3uw3A:
undetectable		 1zz1B-3uw3A:
24.41
1zz1C-3uw3A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 LEU A 356
ASP A 353
GLY A 165
ALA A 360
 None
 0.93A 2aohA-3uw3A:
undetectable		 2aohA-3uw3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 SER A  14
THR A  36
GLN A  72
 None
 0.81A 2fk8A-3uw3A:
undetectable		 2fk8A-3uw3A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 THR A 135
GLN A 280
VAL A 152
ALA A 157
VAL A 263
 None
 1.02A 2g72B-3uw3A:
undetectable		 2g72B-3uw3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 11 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.10A 2o4pA-3uw3A:
undetectable		 2o4pA-3uw3A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 SER A 279
TYR A 160
HIS A 278
 None
 0.75A 2r2vD-3uw3A:
undetectable		 2r2vD-3uw3A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 THR A  70
ILE A 130
LEU A 100
THR A  77
 None
 0.94A 3deuB-3uw3A:
undetectable		 3deuB-3uw3A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 10 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.25A 3lzvA-3uw3A:
undetectable		 3lzvA-3uw3A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 VAL A 309
VAL A 325
SER A 321
 None
 0.70A 3n8xB-3uw3A:
3.3		 3n8xB-3uw3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.10A 3ndwB-3uw3A:
undetectable		 3ndwB-3uw3A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 11 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.17A 3oxxD-3uw3A:
undetectable		 3oxxD-3uw3A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.32A 4c9kA-3uw3A:
undetectable		 4c9kA-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.29A 4c9kB-3uw3A:
undetectable		 4c9kB-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.28A 4c9nB-3uw3A:
undetectable		 4c9nB-3uw3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.34A 4c9pA-3uw3A:
undetectable		 4c9pA-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 THR A 350
LEU A 146
LEU A 143
GLY A 144
VAL A 308
 None
 1.36A 4c9pB-3uw3A:
undetectable		 4c9pB-3uw3A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 ILE A  94
TRP A 357
GLY A 132
ASN A 114
 None
 0.90A 4fgjA-3uw3A:
3.5
4fgjB-3uw3A:
3.5		 4fgjA-3uw3A:
21.23
4fgjB-3uw3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ILE A 298
ALA A 302
ILE A 284
LEU A 286
ILE A 295
 None
 1.10A 4kjkA-3uw3A:
undetectable		 4kjkA-3uw3A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 11 LEU A 370
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 1.36A 4lhmA-3uw3A:
undetectable		 4lhmA-3uw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 11 LEU A 371
VAL A   3
ILE A  69
MET A  20
LEU A  16
 None
 1.04A 4lhmA-3uw3A:
undetectable		 4lhmA-3uw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
 1.05A 4njuA-3uw3A:
undetectable		 4njuA-3uw3A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
 None
 1.05A 4njuC-3uw3A:
undetectable		 4njuC-3uw3A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 GLU A 361
ARG A  19
LEU A  16
ARG A 364
 EDO  A 374 (-3.5A)
EDO  A 374 ( 4.9A)
None
EDO  A 374 (-4.3A)
 1.19A 5l6eA-3uw3A:
undetectable
5l6eB-3uw3A:
undetectable		 5l6eA-3uw3A:
20.21
5l6eB-3uw3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 ALA A  97
GLN A  72
THR A  77
 None
 0.58A 5n0oA-3uw3A:
undetectable		 5n0oA-3uw3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 ARG A 365
ARG A  19
ALA A 360
PRO A 362
 EDO  A 374 (-3.9A)
EDO  A 374 ( 4.9A)
None
None
 1.22A 5odqA-3uw3A:
2.6		 5odqA-3uw3A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 MET A 141
ASP A 111
ARG A  19
 None
None
EDO  A 374 ( 4.9A)
 1.15A 5z6jA-3uw3A:
undetectable		 5z6jA-3uw3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		3 / 3 MET A 141
ASP A 111
ARG A  19
 None
None
EDO  A 374 ( 4.9A)
 1.11A 5z6kA-3uw3A:
undetectable		 5z6kA-3uw3A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 12 LEU A 355
ALA A  96
ASP A  95
ILE A  69
GLY A   7
VAL A  15
 None
 1.08A 6dilA-3uw3A:
undetectable		 6dilA-3uw3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3uw3 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 VAL A  15
LEU A 329
GLY A 327
GLY A 165
 None
EDO  A 374 ( 4.6A)
None
None
 0.77A 6eu9D-3uw3A:
undetectable		 6eu9D-3uw3A:
12.80