SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 1.00A 1fm6U-3uwcA:
undetectable		 1fm6U-3uwcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		6 / 12 GLY A  59
ALA A  62
ASP A  61
ILE A  54
ILE A 196
ILE A 195
 PMP  A 377 (-3.5A)
None
None
None
None
None
 1.42A 1hshA-3uwcA:
undetectable		 1hshA-3uwcA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 11 ALA A 176
HIS A  48
ARG A 207
GLU A  41
ALA A  45
 None
 1.21A 1mjlA-3uwcA:
undetectable
1mjlB-3uwcA:
undetectable		 1mjlA-3uwcA:
15.13
1mjlB-3uwcA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 9 TYR A 285
ASP A 259
LEU A 287
VAL A 361
ILE A 358
 None
 1.15A 1q6iA-3uwcA:
undetectable		 1q6iA-3uwcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 PRO A 139
MET A 138
ALA A 136
GLU A 154
 None
 1.47A 1qhyA-3uwcA:
undetectable		 1qhyA-3uwcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 152
LYS A 143
THR A 123
ILE A 119
ILE A 126
 None
 1.11A 1re7A-3uwcA:
undetectable		 1re7A-3uwcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 7 ALA A 145
ILE A 126
ILE A 110
ASP A 137
 None
None
None
NA  A 373 (-4.8A)
 0.88A 1upfB-3uwcA:
3.8		 1upfB-3uwcA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 LEU A  22
LEU A  19
ILE A 236
ARG A 239
 None
 0.99A 2rlfC-3uwcA:
undetectable
2rlfD-3uwcA:
undetectable		 2rlfC-3uwcA:
12.92
2rlfD-3uwcA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 11 ILE A 196
LEU A 186
ASN A 238
MET A 241
ILE A 160
 None
 1.25A 3a50B-3uwcA:
undetectable		 3a50B-3uwcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 11 ILE A 196
LEU A 186
ASN A 238
MET A 241
ILE A 160
 None
 1.21A 3a50C-3uwcA:
undetectable		 3a50C-3uwcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 5 SER A 261
ARG A 252
GLY A 253
GLU A 249
 None
 1.21A 3k9fA-3uwcA:
0.9
3k9fB-3uwcA:
0.9
3k9fC-3uwcA:
undetectable		 3k9fA-3uwcA:
23.28
3k9fB-3uwcA:
23.28
3k9fC-3uwcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 10 TYR A 285
ASP A 259
LEU A 287
VAL A 361
ILE A 358
 None
 1.13A 3kz7A-3uwcA:
undetectable		 3kz7A-3uwcA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 0.96A 3oapA-3uwcA:
undetectable		 3oapA-3uwcA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 THR A 342
ARG A   2
ILE A 357
LEU A 287
 None
 0.93A 4acbC-3uwcA:
undetectable		 4acbC-3uwcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 152
LYS A 143
THR A 123
ILE A 119
ILE A 126
 None
 1.07A 4kjkA-3uwcA:
undetectable		 4kjkA-3uwcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 5 TYR A   5
ILE A 284
THR A 342
HIS A 280
 EDO  A 376 (-3.5A)
None
None
None
 1.40A 4oltB-3uwcA:
undetectable		 4oltB-3uwcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 152
LYS A 143
THR A 123
ILE A 119
ILE A 126
 None
 1.04A 4p3rA-3uwcA:
undetectable		 4p3rA-3uwcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 152
LYS A 143
THR A 123
ILE A 119
ILE A 126
 None
 1.04A 4pthA-3uwcA:
undetectable		 4pthA-3uwcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 6 TYR A   5
ILE A 284
THR A 342
HIS A 280
 EDO  A 376 (-3.5A)
None
None
None
 1.36A 4qwpA-3uwcA:
undetectable		 4qwpA-3uwcA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 4 ASN A  83
VAL A 340
THR A 132
ILE A 284
 None
 1.42A 4retA-3uwcA:
undetectable		 4retA-3uwcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 4 ASN A  83
VAL A 340
THR A 132
ILE A 284
 None
 1.42A 4retC-3uwcA:
undetectable		 4retC-3uwcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 11 TYR A 285
ASP A 259
LEU A 287
VAL A 361
ILE A 358
 None
 1.15A 5d75A-3uwcA:
undetectable		 5d75A-3uwcA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ILE A 152
LYS A 143
THR A 123
ILE A 119
ILE A 126
 None
 1.12A 5e8qA-3uwcA:
undetectable		 5e8qA-3uwcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 11 TYR A 285
ASP A 259
LEU A 287
VAL A 361
ILE A 358
 None
 1.13A 5gpgA-3uwcA:
undetectable		 5gpgA-3uwcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		4 / 9 ILE A 341
PHE A 296
VAL A 361
ILE A 304
 None
 1.04A 5lg3I-3uwcA:
undetectable		 5lg3I-3uwcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 10 TYR A   7
ILE A 354
LEU A 257
ILE A 247
ASN A 185
 EDO  A 376 ( 4.7A)
None
None
None
None
 1.32A 5vkqA-3uwcA:
undetectable
5vkqD-3uwcA:
undetectable		 5vkqA-3uwcA:
12.44
5vkqD-3uwcA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3uwc NUCLEOTIDE-SUGAR
AMINOTRANSFERASE
(Coxiella
burnetii) 		5 / 12 ALA A  91
LEU A  63
ALA A  64
ILE A 110
LEU A 101
 None
 0.92A 6a5yD-3uwcA:
undetectable		 6a5yD-3uwcA:
13.47