SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		4 / 5 PHE A  63
SER A  71
PHE A  58
ILE A 102
 None
XPE  A 233 (-4.1A)
None
None
 1.37A 2v0mD-3uwqA:
undetectable		 2v0mD-3uwqA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		5 / 12 LEU A 165
GLU A 161
HIS A 139
ALA A  89
SER A  90
 None
 1.49A 3apvA-3uwqA:
undetectable		 3apvA-3uwqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		5 / 12 LEU A 119
ILE A 132
ILE A 130
HIS A 139
LEU A 146
 None
 1.30A 3gwxA-3uwqA:
undetectable		 3gwxA-3uwqA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		4 / 6 LEU A 165
GLN A 137
LEU A 164
GLU A 161
 None
 0.94A 3h5gB-3uwqA:
undetectable
3h5gC-3uwqA:
undetectable		 3h5gB-3uwqA:
7.57
3h5gC-3uwqA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3uwq OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Vibrio
cholerae) 		5 / 12 PHE A  46
GLU A  37
VAL A 208
THR A 214
GLY A 210
 None
None
U5P  A 232 (-4.9A)
PEG  A 234 ( 4.5A)
U5P  A 232 (-3.4A)
 1.01A 5tuiB-3uwqA:
undetectable		 5tuiB-3uwqA:
24.22