SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 LYS B 279
TYR B 295
PRO B 278
 None
 1.21A 2j9cC-3uwsB:
undetectable		 2j9cC-3uwsB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 7 ILE B 264
PRO B 352
LEU B 276
ILE B 273
 None
 0.85A 2q83A-3uwsB:
undetectable		 2q83A-3uwsB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 6 ILE B 264
PRO B 352
LEU B 276
ILE B 273
 None
 0.84A 2q83B-3uwsB:
undetectable		 2q83B-3uwsB:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 8 TYR B 233
SER B 330
GLN B 282
SER B 200
 None
 1.17A 2xz5B-3uwsB:
undetectable
2xz5E-3uwsB:
undetectable		 2xz5B-3uwsB:
20.82
2xz5E-3uwsB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_A_ACHA323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 9 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.47A 3rqwA-3uwsB:
0.0
3rqwB-3uwsB:
0.0		 3rqwA-3uwsB:
20.73
3rqwB-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_B_ACHB323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 9 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.48A 3rqwB-3uwsB:
0.0
3rqwC-3uwsB:
0.0		 3rqwB-3uwsB:
20.73
3rqwC-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 8 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.49A 3rqwC-3uwsB:
undetectable
3rqwD-3uwsB:
undetectable		 3rqwC-3uwsB:
20.73
3rqwD-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_E_ACHE323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 9 GLU B 185
TYR B 363
LEU B 360
PHE B 350
TYR B 374
 None
None
None
None
EDO  B 402 ( 4.7A)
 1.49A 3rqwA-3uwsB:
0.0
3rqwE-3uwsB:
0.0		 3rqwA-3uwsB:
20.73
3rqwE-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_F_ACHF323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 9 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.47A 3rqwF-3uwsB:
0.0
3rqwG-3uwsB:
0.5		 3rqwF-3uwsB:
20.73
3rqwG-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_G_ACHG323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 9 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.49A 3rqwG-3uwsB:
0.5
3rqwH-3uwsB:
0.0		 3rqwG-3uwsB:
20.73
3rqwH-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 8 TYR B 374
GLU B 185
TYR B 363
LEU B 360
PHE B 350
 EDO  B 402 ( 4.7A)
None
None
None
None
 1.49A 3rqwI-3uwsB:
undetectable
3rqwJ-3uwsB:
undetectable		 3rqwI-3uwsB:
20.73
3rqwJ-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		5 / 8 GLU B 185
TYR B 363
LEU B 360
PHE B 350
TYR B 374
 None
None
None
None
EDO  B 402 ( 4.7A)
 1.50A 3rqwF-3uwsB:
undetectable
3rqwJ-3uwsB:
undetectable		 3rqwF-3uwsB:
20.73
3rqwJ-3uwsB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 TYR B 241
GLU B 203
TYR B 332
 None
 0.81A 3ug8A-3uwsB:
undetectable		 3ug8A-3uwsB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 6 LEU B 248
LEU B 223
ILE B 174
PHE B 173
 None
EDO  B 401 (-4.8A)
None
None
 1.12A 4y4dA-3uwsB:
undetectable		 4y4dA-3uwsB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		3 / 3 ARG B 312
ILE B 314
PHE B 313
 None
 0.72A 5kirA-3uwsB:
undetectable		 5kirA-3uwsB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3uws HYPOTHETICAL PROTEIN
(Parabacteroides
merdae) 		4 / 4 LEU B 317
ARG B 312
ILE B 314
PHE B 313
 None
 0.94A 5kirB-3uwsB:
undetectable		 5kirB-3uwsB:
16.19