SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ux4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		4 / 8 SER A 108
PRO A 165
LEU A 166
THR A 115
 None
 1.20A 2v0zO-3ux4A:
undetectable		 2v0zO-3ux4A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		4 / 6 TYR A   8
TYR A  88
PHE A  34
LEU A  89
 None
 1.20A 2w98A-3ux4A:
undetectable
2w98B-3ux4A:
undetectable		 2w98A-3ux4A:
20.33
2w98B-3ux4A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		5 / 9 LEU A 154
SER A 108
LEU A 109
SER A 105
GLU A 159
 None
 1.12A 3ai9X-3ux4A:
undetectable		 3ai9X-3ux4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		4 / 6 TYR A  90
ALA A  91
ALA A 156
THR A 155
 None
 0.88A 3b6hB-3ux4A:
undetectable		 3b6hB-3ux4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		3 / 3 ASP A 100
ASN A 160
PHE A  97
 None
 0.89A 5jglB-3ux4A:
undetectable		 5jglB-3ux4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3ux4 ACID-ACTIVATED UREA
CHANNEL
(Helicobacter
pylori) 		3 / 3 LEU A   4
LEU A   7
TRP A 183
 None
 0.72A 5nwuA-3ux4A:
undetectable		 5nwuA-3ux4A:
12.66