SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 GLU A 145
THR A 123
ALA A 129
LEU A  48
 None
 0.89A 1etb2-3uxfA:
6.5		 1etb2-3uxfA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 ILE A 324
ASN A 326
SER A 328
THR A 148
 None
 1.13A 1h7xA-3uxfA:
undetectable		 1h7xA-3uxfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 ILE A 324
ASN A 326
SER A 328
THR A 148
 None
 1.13A 1h7xB-3uxfA:
undetectable		 1h7xB-3uxfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 ILE A 324
ASN A 326
SER A 328
THR A 148
 None
 1.13A 1h7xC-3uxfA:
undetectable		 1h7xC-3uxfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 ILE A 324
ASN A 326
SER A 328
THR A 148
 None
 1.14A 1h7xD-3uxfA:
undetectable		 1h7xD-3uxfA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 LEU A 278
LEU A 323
GLY A 322
ILE A 208
 None
 0.85A 1mt1G-3uxfA:
undetectable
1mt1J-3uxfA:
undetectable		 1mt1G-3uxfA:
7.99
1mt1J-3uxfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 7 ILE A 208
LEU A 278
LEU A 323
GLY A 322
 None
 0.86A 1mt1H-3uxfA:
undetectable
1mt1K-3uxfA:
undetectable		 1mt1H-3uxfA:
11.91
1mt1K-3uxfA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 8 LEU A 278
LEU A 323
GLY A 322
ILE A 208
 None
 0.83A 1n13A-3uxfA:
undetectable
1n13F-3uxfA:
undetectable		 1n13A-3uxfA:
7.99
1n13F-3uxfA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		5 / 10 PHE A  82
LEU A  48
VAL A 160
PHE A 158
VAL A  50
 None
 1.38A 1q23K-3uxfA:
undetectable		 1q23K-3uxfA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 8 GLU A 145
THR A 123
ALA A 129
LEU A  48
 None
 0.94A 1sn5C-3uxfA:
6.5		 1sn5C-3uxfA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 8 ILE A 208
LEU A 278
LEU A 323
GLY A 322
 None
 0.86A 2qqcH-3uxfA:
undetectable
2qqcK-3uxfA:
undetectable		 2qqcH-3uxfA:
12.86
2qqcK-3uxfA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 8 ILE A 208
LEU A 278
LEU A 323
GLY A 322
 None
 0.74A 2qqdB-3uxfA:
undetectable
2qqdC-3uxfA:
undetectable		 2qqdB-3uxfA:
12.86
2qqdC-3uxfA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 TYR A 447
LEU A 471
LYS A 439
ASP A 440
 None
 1.45A 2w98A-3uxfA:
undetectable
2w98B-3uxfA:
undetectable		 2w98A-3uxfA:
21.05
2w98B-3uxfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		5 / 7 THR A 373
GLY A 421
ASN A 376
GLY A 365
THR A 366
 None
 1.40A 3tajA-3uxfA:
undetectable		 3tajA-3uxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		3 / 3 TRP A 273
TRP A 333
THR A 275
 None
 1.44A 4bboB-3uxfA:
undetectable		 4bboB-3uxfA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 4 VAL A  77
VAL A  80
ASN A 183
ILE A 153
 None
 1.19A 4cutA-3uxfA:
undetectable		 4cutA-3uxfA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		5 / 12 GLY A 322
TYR A 206
ILE A 347
ILE A 324
TRP A 333
 None
 1.22A 4xucA-3uxfA:
undetectable		 4xucA-3uxfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		5 / 12 GLY A 322
TYR A 206
ILE A 347
ILE A 324
TRP A 333
 None
 1.31A 4xudA-3uxfA:
undetectable		 4xudA-3uxfA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 ARG A 222
ARG A 283
ALA A 286
GLU A 281
 None
 1.33A 5odqA-3uxfA:
undetectable		 5odqA-3uxfA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 8 GLU A 452
PRO A 456
GLN A 379
GLY A 377
 None
 0.91A 5w3jB-3uxfA:
undetectable		 5w3jB-3uxfA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 6 GLU A 314
TYR A 427
GLY A 410
GLY A 411
 None
 0.84A 5x7pB-3uxfA:
undetectable		 5x7pB-3uxfA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 5 VAL A 215
PRO A 218
GLY A 219
TYR A 217
 None
 1.29A 5x80A-3uxfA:
undetectable
5x80B-3uxfA:
undetectable		 5x80A-3uxfA:
16.97
5x80B-3uxfA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 5 VAL A 215
PRO A 218
GLY A 220
TYR A 217
 None
 1.12A 5x80A-3uxfA:
undetectable
5x80B-3uxfA:
undetectable		 5x80A-3uxfA:
16.97
5x80B-3uxfA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		5 / 7 ALA A 321
THR A 320
ILE A 324
VAL A 228
PRO A 335
 None
 1.43A 6cduF-3uxfA:
2.7
6cduJ-3uxfA:
2.6		 6cduF-3uxfA:
20.55
6cduJ-3uxfA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3uxf FIMBRIAL SUBUNIT
TYPE 1
(Actinomyces
oris) 		4 / 5 GLN A  55
THR A  56
THR A 148
GLY A 187
 None
 1.23A 6gbnC-3uxfA:
undetectable		 6gbnC-3uxfA:
21.71