SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3uxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  64
VAL A  76
LEU A  10
LEU A 117
LEU A  73
 None
 0.90A 1mx1D-3uxyA:
undetectable		 1mx1D-3uxyA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 12 ILE A  75
LEU A  70
GLY A  30
PHE A   4
ALA A  45
 None
 1.13A 1tsnA-3uxyA:
undetectable		 1tsnA-3uxyA:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		7 / 11 GLY A  13
ALA A  15
ASP A  37
ASP A  52
ALA A  80
VAL A  82
VAL A 102
 None
 0.78A 1uayA-3uxyA:
28.7		 1uayA-3uxyA:
31.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		7 / 10 GLY A  13
ALA A  15
ASP A  37
ASP A  52
ALA A  80
VAL A  82
VAL A 102
 None
 0.76A 1uayB-3uxyA:
29.5		 1uayB-3uxyA:
31.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		4 / 8 ALA A  44
VAL A  23
THR A  24
ASP A  46
 None
 1.25A 2kotB-3uxyA:
undetectable		 2kotB-3uxyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 10 ASN A 103
VAL A  82
THR A 147
LEU A 143
THR A  91
 None
 1.13A 3bexA-3uxyA:
undetectable
3bexB-3uxyA:
1.1		 3bexA-3uxyA:
22.46
3bexB-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ASN A 103
VAL A  82
THR A 147
LEU A 143
THR A  91
 None
 1.12A 3bexC-3uxyA:
undetectable
3bexD-3uxyA:
undetectable		 3bexC-3uxyA:
22.46
3bexD-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 THR A 147
LEU A 143
THR A  91
ASN A 103
VAL A  82
 None
 1.13A 3bexE-3uxyA:
undetectable
3bexF-3uxyA:
undetectable		 3bexE-3uxyA:
22.46
3bexF-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ASN A 103
VAL A  82
THR A 147
LEU A 143
THR A  91
 None
 1.14A 3bf1A-3uxyA:
undetectable
3bf1B-3uxyA:
undetectable		 3bf1A-3uxyA:
22.46
3bf1B-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 12 THR A 147
LEU A 143
THR A  91
ASN A 103
VAL A  82
 None
 1.13A 3bf1A-3uxyA:
undetectable
3bf1B-3uxyA:
undetectable		 3bf1A-3uxyA:
22.46
3bf1B-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ASN A 103
VAL A  82
THR A 147
LEU A 143
THR A  91
 None
 1.10A 3bf1C-3uxyA:
1.9
3bf1D-3uxyA:
1.7		 3bf1C-3uxyA:
22.46
3bf1D-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 THR A 147
LEU A 143
THR A  91
ASN A 103
VAL A  82
 None
 1.15A 3bf1C-3uxyA:
1.9
3bf1D-3uxyA:
undetectable		 3bf1C-3uxyA:
22.46
3bf1D-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ASN A 103
VAL A  82
THR A 147
LEU A 143
THR A  91
 None
 1.14A 3bf1E-3uxyA:
1.6
3bf1F-3uxyA:
1.6		 3bf1E-3uxyA:
22.46
3bf1F-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 THR A 147
LEU A 143
THR A  91
ASN A 103
VAL A  82
 None
 1.14A 3bf1E-3uxyA:
1.7
3bf1F-3uxyA:
1.6		 3bf1E-3uxyA:
22.46
3bf1F-3uxyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		4 / 5 PRO A 212
THR A 203
VAL A 204
GLY A 201
 None
 1.15A 3elzA-3uxyA:
undetectable		 3elzA-3uxyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 10 ARG A  54
ILE A  18
GLY A  17
GLY A  16
VAL A  82
 None
 0.99A 3em4V-3uxyA:
undetectable		 3em4V-3uxyA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  13
GLY A  16
ASP A  52
LEU A  53
ARG A  54
 None
 0.98A 3o7wA-3uxyA:
4.5		 3o7wA-3uxyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ILE A 215
ILE A  18
GLY A  17
SER A  84
GLY A  81
 None
 0.94A 4ac9B-3uxyA:
6.0
4ac9C-3uxyA:
5.9		 4ac9B-3uxyA:
22.27
4ac9C-3uxyA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		4 / 5 LEU A 200
ARG A 208
PRO A 174
SER A 131
 None
 1.39A 4kmmB-3uxyA:
2.3		 4kmmB-3uxyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		3 / 3 THR A  92
ASP A  93
ALA A  94
 None
 0.00A 5g5gB-3uxyA:
undetectable		 5g5gB-3uxyA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		4 / 5 HIS A 162
VAL A  76
GLY A 124
ALA A 125
 None
 0.99A 5hwaA-3uxyA:
undetectable		 5hwaA-3uxyA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 12 ILE A  18
VAL A  23
ALA A   9
LEU A  73
GLY A 124
 None
 1.02A 5igtA-3uxyA:
undetectable		 5igtA-3uxyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Rhodobacter
sphaeroides) 		5 / 11 ALA A 223
VAL A 127
VAL A  11
ILE A  18
ALA A  25
 None
 1.07A 6h1lB-3uxyA:
undetectable		 6h1lB-3uxyA:
18.90